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International Journal of Clinical Oncology

Erschienen in:

01.06.2014 | Original Article

Boron neutron capture therapy for advanced salivary gland carcinoma in head and neck

verfasst von: Teruhito Aihara, Norimasa Morita, Nobuhiko Kamitani, Hiroaki Kumada, Koji Ono, Junichi Hiratsuka, Tamotu Harada

Erschienen in: International Journal of Clinical Oncology | Ausgabe 3/2014

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Abstract

Purpose

Boron neutron capture therapy (BNCT) is among the radiation treatments known to have a selective lethal effect on tumor cells. This study summarizes the tumor responses and the acute and late adverse effects of BNCT in the treatment of patients with both recurrent and newly diagnosed T4 salivary gland carcinoma.

Methods

Two patients with recurrent cancer and 3 with newly diagnosed T4 advanced malignancy were registered between October 2003 and September 2007, with the approval of the medical ethics committees of Kawasaki Medical School and Kyoto University. BNCT was performed, in a single fraction using an epithermal beam, at Japan Research Reactor 4.

Results

All patients achieved a complete response within 6 months of treatment. The median duration of the complete response was 24.0 months; the median overall survival time was 32.0 months. Three of the 5 patients are still alive; the other 2 died of distant metastatic disease. Open biopsy of the parotid gland after BNCT was performed in 1 patient and revealed no residual viable cancer cells and no serious damage to the normal glandular system. Although mild alopecia, xerostomia, and fatigue occurred in all patients, there were no severe adverse effects of grade 3 or greater.

Conclusions

Our preliminary results demonstrate that BNCT is a potential curative therapy for patients with salivary gland carcinoma. The treatment does not cause any serious adverse effects, and may be used regardless of whether the primary tumor has been previously treated.

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Titel: Boron neutron capture therapy for advanced salivary gland carcinoma in head and neck
verfasst von: Teruhito Aihara
Norimasa Morita
Nobuhiko Kamitani
Hiroaki Kumada
Koji Ono
Junichi Hiratsuka
Tamotu Harada
Publikationsdatum: 01.06.2014
Verlag: Springer Japan
Erschienen in: International Journal of Clinical Oncology / Ausgabe 3/2014
Print ISSN: 1341-9625
Elektronische ISSN: 1437-7772
DOI: https://doi.org/10.1007/s10147-013-0580-3

Springer Medizin

Boron neutron capture therapy for advanced salivary gland carcinoma in head and neck