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Acta Neuropathologica

Erschienen in:

01.04.2016 | Review

Brain imaging of neurovascular dysfunction in Alzheimer’s disease

verfasst von: Axel Montagne, Daniel A. Nation, Judy Pa, Melanie D. Sweeney, Arthur W. Toga, Berislav V. Zlokovic

Erschienen in: Acta Neuropathologica | Ausgabe 5/2016

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Abstract

Neurovascular dysfunction, including blood–brain barrier (BBB) breakdown and cerebral blood flow (CBF) dysregulation and reduction, are increasingly recognized to contribute to Alzheimer’s disease (AD). The spatial and temporal relationships between different pathophysiological events during preclinical stages of AD, including cerebrovascular dysfunction and pathology, amyloid and tau pathology, and brain structural and functional changes remain, however, still unclear. Recent advances in neuroimaging techniques, i.e., magnetic resonance imaging (MRI) and positron emission tomography (PET), offer new possibilities to understand how the human brain works in health and disease. This includes methods to detect subtle regional changes in the cerebrovascular system integrity. Here, we focus on the neurovascular imaging techniques to evaluate regional BBB permeability (dynamic contrast-enhanced MRI), regional CBF changes (arterial spin labeling- and functional-MRI), vascular pathology (structural MRI), and cerebral metabolism (PET) in the living human brain, and examine how they can inform about neurovascular dysfunction and vascular pathophysiology in dementia and AD. Altogether, these neuroimaging approaches will continue to elucidate the spatio-temporal progression of vascular and neurodegenerative processes in dementia and AD and how they relate to each other.

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Titel: Brain imaging of neurovascular dysfunction in Alzheimer’s disease
verfasst von: Axel Montagne
Daniel A. Nation
Judy Pa
Melanie D. Sweeney
Arthur W. Toga
Berislav V. Zlokovic
Publikationsdatum: 01.04.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Acta Neuropathologica / Ausgabe 5/2016
Print ISSN: 0001-6322
Elektronische ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-016-1570-0

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