Background
Methods
Subjects
Study design
Instruments
Motor functioning assessment
Depression assessment
Cognitive function
Sleep quality evaluation
MRI acquisition
Image processing and analysis
Statistical analysis
Results
Characteristic | Parkinson’s disease patients | Controls | P valuea |
---|---|---|---|
Age (years) | 58 [55–63] | 55 [49–65] | 0.15 |
Male/Female (number) | 14/14 | 14/14 | 0.78 |
Levodopa dosage equivalence mg | 600[400–785] | – | |
UPDRS – III (score) | 18[12–21] | – | |
MMSE (score) | 28[26–29] | 29[27–30] | 0.15b |
PDSS (score) overall | 81.3[64.4–109.9] | – |
Sleep quality evaluation
Depressive and anxiety symptoms
Voxel based morphometry
PD vs. controls
Region | Parkinson’s disease | Controls | Univariatea | Adjustedb |
---|---|---|---|---|
Thickness | ||||
mm ± SD | mm ± SD | (df) = F, p | (df) = F, p | |
Left caudal middle frontal | 2.53 ± 0.19 | 2.61 ± 0.98 | (1,55) = 4.3, 0.04 | (1,55) = 0.7, 0.38 |
Left fusiform |
2.68 ± 0.14
|
2.77 ± 0.95
|
(1,55) = 5.7, 0.02
|
(1,55) = 4.5, 0.03
|
Left parahipocampal |
2.61 ± 0.37
|
3.00 ± 0.23
|
(1,55) = 16.3, 0.001
|
(1,55) = 14.4, 0.001
|
Left posterior cingulate |
2.37 ± 0.16
|
2.48 ± 0.17
|
(1,55) = 5.0, 0.02
|
(1,55) = 6.1, 0.01
|
Left precentral |
2.27 ± 0.19
|
2.41 ± 0.18
|
(1,55) = 7.6, 0.008
|
(1,55) = 4.9, 0.03
|
Right caudal anterior cingulate |
2.39 ± 0.30
|
2.56 ± 0.24
|
(1,55) = 4.2, 0.04
|
(1,55) = 4.0, 0.05
|
Right isthmus cingulate | 2.20 ± 0.16 | 2.30 ± 0.12 | (1,55) = 5.1, 0.01 | (1,55) = 2.6, 0.11 |
Right parahipocampal |
2.67 ± 0.29
|
2.91 ± 0.21
|
(1,55) = 2.0, 0.001
|
(1,55) = 8.3, 0.006
|
Right precentral |
2.28 ± 0.22
|
2.41 ± 0.10
|
(1,55) = 5.5, 0.02
|
(1,55) = 4.1, 0.05
|
Right superior temporal | 2.85 ± 0.13 | 2.92 ± 0.09 | (1,55) = 4.6, 0.02 | (1,55) = 3.01, 0.07 |
Right transverse temporal | 2.25 ± 0.25 | 2.39 ± 0.17 | (1,55) = 4.3, 0.04 | (1,55) = 3.1, 0.08 |
Subcortical structures | ||||
mm
3
± SD | mm
3
± SD |
(df) = F, p
|
(df) = F, p
| |
Left lateral ventricule |
75.47 ± 31.86
|
153.88 ± 145.9
|
(1,55) = 5.0, 0.02
|
(1,55) = 4.01, 0.05
|
Right lateral ventricule |
71.53 ± 27.21
|
132.92 ± 115.21
|
(1,55) = 4.39 0.03
|
(1,55) = 4.4, 0.04
|
Right hipocampus total |
42.63 ± 28.8
|
40.41 ± 49.18
|
(1,55) = 5.9, 0.03
|
(1,55) = 6.1, 0.01
|
Left hipocampus total |
41.54 ± 38.6
|
39.16 ± 44.0
|
(1,55) = 3.8, 0.05
|
(1,55) = 6.5, 0.01
|
Left amygdala |
15.89 ± 22.0
|
14.57 ± 20.03
|
(1,55) = 4.9, 0.03
|
(1,55) = 9.8, 0.003
|
Brainstem structures | ||||
mm
3
± SD | mm
3
± SD |
(df) = F, p
|
(df) = F, p
| |
Superior cereberal peduncle |
25.84 ± 4.66
|
32.08 ± 9.43
|
(1,55) = 7.0, 0.01
|
(1,55) = 5.4, 0.02
|
White matter volume | ||||
mm
3
± SD | mm
3
± SD |
(df) = F, p
|
(df) = F, p
| |
Left inferior parietal | 9.96 ± 0.13 | 10.03 ± 0.11 | (1,55) = 3.7, 0.05 | (1,55) = 3.1, 0.08 |
Left rostral middle frontal |
9.98 ± 0.07
|
10.04 ± 0.15
|
(1,55) = 4.9, 0.03
|
(1,55) = 4.0, 0.04
|
Left superior parietal | 10.05 ± 0.05 | 10.01 ± 0.17 | (1,55) = 1.93, 0.05 | (1,55) = 1.2, 0.2 |
Left frontal pole |
9.44 ± 0.25
|
9.64 ± 0.19
|
(1,55) = 8.8, 0.004
|
(1,55) = 5.9, 0.01
|
Left insula | 9.69 ± 0.07 | 9.70 ± 0.21 | (1,55) = 5.7, 0.02 | (1,55) = 3.3, 0.07 |
Right entorhinal |
8.67 ± 0.21
|
8.87 ± 0.18
|
(1,55) = 11.5, 0.001
|
(1,55) = 10.6, 0.002
|
Right transverse temporal |
9.73 ± 0.16
|
9.88 ± 0.19
|
(1,55) = 8.4, 0.005
|
(1,55) = 6.1, 0.01
|
Right insula | 9.42 ± 0.10 | 9.52 ± 0.21 | (1,55) = 3.7, 0.05 | (1,55) = 2.8, 0.09 |
Surface area | ||||
mm
2
± SD | mm
2
± SD |
(df) = F, p
|
(df) = F, p
| |
Left frontal pole |
23.20 ± 2.96
|
25.15 ± 3.51
|
(1,55) = 4.69, 0.03
|
(1,55) = 7.6, 0.008
|
Right frontal pole | 28.01 ± 3.43 | 30.05 ± 3.10 | (1.55) = 4.62, 0.03 | (1,55) = 3.47, 0.06 |
Cortical thickness
White matter volume
Cortical surface area
Fidget in the bed | Distressing dreams | |||
---|---|---|---|---|
Univariate β(p) | Adjusted β(p)a | Univariate β(p) | Adjusted β(p)a | |
Left lateral occipital |
0.58 (0.001)
|
0.49(0.02)
| 0.12(0.08) | – |
Left lateral orbitofrontal |
0.59(0.001)
|
0.28(0.01)
| 0.58(0.001) | 0.27(0.12) |
Left paracentral | 0.24(0.07) | – |
0.54(0.003)
|
0.43(0.05)
|
Pars obitalis | 0.58(0.001) | 0.32(0.08) |
0.63(0.0001)
|
0.42(0.01)
|
Left tranverse temporal |
0.64 (0.0001)
|
0.47(0.01)
| 0.18(0.2) | – |
Right lateral occipital | 0.53(0.003) | 0.36(0.07) | 0.09(0.4) | – |
Right medial orbitofrontal |
0.59(0.001)
|
0.49(0.009)
| 0.21(0.06) | – |
Right postcentral | 0.24(0.1) | – |
0.56, 0.002
|
0.43(0.01)
|
Right superior frontal | 0.56(0.002) | 0.22(0.11) |
0.55, 0.002
|
0.29(0.03)
|
Left hemisphere area total surface |
0.54(0.003)
|
0.26(0.04)
| 0.21(0.07) | – |
Subcortical structures
Subcortical structures | Nocturnal hallucinations | ||
---|---|---|---|
Univariate β(p) | Adjusted β(p)a | ||
Right | Accumbens |
0.66(< 0.001)
|
0.42(0.01)
|
Thalamus |
0.58(< 0.001)
| 0.16(0.18) | |
Putamen |
0.65(< 0.001)
|
0.38(0.01)
| |
Pallidum |
0.56(0.002)
| 0.26(0.07) | |
Left | Accumbens |
0.61(0,001)
|
0.45(0.01)
|
Thalamus |
0.64(< 0.001)
| 0.24(0.06) | |
Putamen |
0.69(< 0.001)
|
0.39(0.01)
| |
Pallidum |
0.52(0.004)
| 0.26(0.06) |