Skip to main content
Erschienen in: Current Diabetes Reports 12/2019

01.12.2019 | Obesity (KM Gadde, Section Editor)

Brain Stimulation to Modulate Food Intake and Eating Behavior

verfasst von: Rebecca Dendy, Emma J. Stinson, Nicolas Guerithault, Marci E. Gluck

Erschienen in: Current Diabetes Reports | Ausgabe 12/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

Appetitive behaviors are mediated through homeostatic and reward signaling of brain circuits. There has been increasing interest in the use of neuromodulation techniques aimed at targeting brain regions such as the lateral prefrontal and subcortical regions associated with dysregulation of eating behaviors.

Recent Findings

Invasive brain stimulation techniques have demonstrated promising results in treating severe and enduring anorexia nervosa and morbid obesity. In addition, non-invasive techniques have been shown to successfully reduce food craving, hunger ratings, and calorie intake as well as binge/purge symptoms in eating disorders.

Summary

Brain stimulation offers promising results for treating symptoms associated with eating disorders and modifying appetitive behaviors including craving and caloric consumption. Future research should focus on identifying optimal frequency and duration of stimulation and employ longitudinal studies to assess long-term effectiveness on clinical outcomes such as eating disorder symptomatology, weight loss, and sustained improvements in eating behaviors over time.
Literatur
2.
Zurück zum Zitat Volkow ND, Wise RA. How can drug addiction help us understand obesity? Nat Neurosci. 2005;8(5):555–60.CrossRef Volkow ND, Wise RA. How can drug addiction help us understand obesity? Nat Neurosci. 2005;8(5):555–60.CrossRef
3.
Zurück zum Zitat Volkow ND, Wang GJ, Tomasi D, Baler RD. Obesity and addiction: neurobiological overlaps. Obes Rev. 2013;14(1):2–18.CrossRef Volkow ND, Wang GJ, Tomasi D, Baler RD. Obesity and addiction: neurobiological overlaps. Obes Rev. 2013;14(1):2–18.CrossRef
4.
Zurück zum Zitat Stice E, Figlewicz DP, Gosnell BA, Levine AS, Pratt WE. The contribution of brain reward circuits to the obesity epidemic. Neurosci Biobehav Rev. 2013;37(9):2047–58.CrossRef Stice E, Figlewicz DP, Gosnell BA, Levine AS, Pratt WE. The contribution of brain reward circuits to the obesity epidemic. Neurosci Biobehav Rev. 2013;37(9):2047–58.CrossRef
5.
Zurück zum Zitat Monteleone AM, Castellini G, Volpe U, Ricca V, Lelli L, Monteleone P, et al. Neuroendocrinology and brain imaging of reward in eating disorders: a possible key to the treatment of anorexia nervosa and bulimia nervosa. Prog Neuro-Psychopharmacol Biol Psychiatry. 2018;80:132–42.CrossRef Monteleone AM, Castellini G, Volpe U, Ricca V, Lelli L, Monteleone P, et al. Neuroendocrinology and brain imaging of reward in eating disorders: a possible key to the treatment of anorexia nervosa and bulimia nervosa. Prog Neuro-Psychopharmacol Biol Psychiatry. 2018;80:132–42.CrossRef
6.
Zurück zum Zitat Lapenta OM, Di Sierve K, de Macedo EC, Fregni F, Boggio PS. Transcranial direct current stimulation modulates ERP-indexed inhibitory control and reduces food consumption. Appetite. 2014;83:42–8.CrossRef Lapenta OM, Di Sierve K, de Macedo EC, Fregni F, Boggio PS. Transcranial direct current stimulation modulates ERP-indexed inhibitory control and reduces food consumption. Appetite. 2014;83:42–8.CrossRef
8.
Zurück zum Zitat •• Le DS, Pannacciulli N, Chen K, Del Parigi A, Salbe AD, Reiman EM, et al. Less activation of the left dorsolateral prefrontal cortex in response to a meal: a feature of obesity. Am J Clin Nutr. 2006;84(4):725–31. https://doi.org/10.1093/ajcn/84.4.725. Seminal study demonstrating lesser dlPFC activation in obese vs. lean.CrossRefPubMed •• Le DS, Pannacciulli N, Chen K, Del Parigi A, Salbe AD, Reiman EM, et al. Less activation of the left dorsolateral prefrontal cortex in response to a meal: a feature of obesity. Am J Clin Nutr. 2006;84(4):725–31. https://​doi.​org/​10.​1093/​ajcn/​84.​4.​725. Seminal study demonstrating lesser dlPFC activation in obese vs. lean.CrossRefPubMed
9.
10.
Zurück zum Zitat Le DS, Chen K, Pannacciulli N, Gluck M, Reiman EM, Krakoff J. Reanalysis of the obesity-related attenuation in the left dorsolateral prefrontal cortex response to a satiating meal using gyral regions-of-interest. J Am Coll Nutr. 2009;28(6):667–73.CrossRef Le DS, Chen K, Pannacciulli N, Gluck M, Reiman EM, Krakoff J. Reanalysis of the obesity-related attenuation in the left dorsolateral prefrontal cortex response to a satiating meal using gyral regions-of-interest. J Am Coll Nutr. 2009;28(6):667–73.CrossRef
12.
Zurück zum Zitat Kumar R, Simpson CV, Froelich CA, Baughman BC, Gienapp AJ, Sillay KA. Obesity and deep brain stimulation: an overview. Ann Neurosci. 2015;22(3):181–8.CrossRef Kumar R, Simpson CV, Froelich CA, Baughman BC, Gienapp AJ, Sillay KA. Obesity and deep brain stimulation: an overview. Ann Neurosci. 2015;22(3):181–8.CrossRef
14.
Zurück zum Zitat Herrington T, Eskandar E. 24 - deep brain stimulation. In: Kumar MKW, Levine JM, Schuster J, editors. Neurocritical care management of the neurosurgical patient. London: Elsevier; 2018. p. 241–51.CrossRef Herrington T, Eskandar E. 24 - deep brain stimulation. In: Kumar MKW, Levine JM, Schuster J, editors. Neurocritical care management of the neurosurgical patient. London: Elsevier; 2018. p. 241–51.CrossRef
17.
Zurück zum Zitat Bielajew C, Stenger J, Schindler D. Factors that contribute to the reduced weight gain following chronic ventromedial hypothalamic stimulation. Behav Brain Res. 1994;62(2):143–8.CrossRef Bielajew C, Stenger J, Schindler D. Factors that contribute to the reduced weight gain following chronic ventromedial hypothalamic stimulation. Behav Brain Res. 1994;62(2):143–8.CrossRef
18.
20.
Zurück zum Zitat Wu H, Van Dyck-Lippens PJ, Santegoeds R, van Kuyck K, Gabriëls L, Lin G, et al. Deep-brain stimulation for anorexia nervosa. World Neurosurg. 2013;80(3–4):S29 e1-S. e10.PubMed Wu H, Van Dyck-Lippens PJ, Santegoeds R, van Kuyck K, Gabriëls L, Lin G, et al. Deep-brain stimulation for anorexia nervosa. World Neurosurg. 2013;80(3–4):S29 e1-S. e10.PubMed
28.
Zurück zum Zitat Manning KE, McAllister CJ, Ring HA, Finer N, Kelly CL, Sylvester KP, et al. Novel insights into maladaptive behaviours in Prader-Willi syndrome: serendipitous findings from an open trial of vagus nerve stimulation. J Intellect Disability Res : JIDR. 2016;60(2):149–55. https://doi.org/10.1111/jir.12203.CrossRef Manning KE, McAllister CJ, Ring HA, Finer N, Kelly CL, Sylvester KP, et al. Novel insights into maladaptive behaviours in Prader-Willi syndrome: serendipitous findings from an open trial of vagus nerve stimulation. J Intellect Disability Res : JIDR. 2016;60(2):149–55. https://​doi.​org/​10.​1111/​jir.​12203.CrossRef
35.
Zurück zum Zitat Johann M, Wiegand R, Kharraz A, Bobbe G, Sommer G, Hajak G, et al. Repetitiv transcranial magnetic stimulation in nicotine dependence. Psychiatr Prax. 2003;30(Suppl 2):129–31. Johann M, Wiegand R, Kharraz A, Bobbe G, Sommer G, Hajak G, et al. Repetitiv transcranial magnetic stimulation in nicotine dependence. Psychiatr Prax. 2003;30(Suppl 2):129–31.
37.
Zurück zum Zitat Eichhammer P, Johann M, Kharraz A, Binder H, Pittrow D, Wodarz N, et al. High-frequency repetitive transcranial magnetic stimulation decreases cigarette smoking. J Clin Psychiatry. 2003;64(8):951–3.CrossRef Eichhammer P, Johann M, Kharraz A, Binder H, Pittrow D, Wodarz N, et al. High-frequency repetitive transcranial magnetic stimulation decreases cigarette smoking. J Clin Psychiatry. 2003;64(8):951–3.CrossRef
39.
Zurück zum Zitat •• Hall PA, Vincent CM, Burhan AM. Non-invasive brain stimulation for food cravings, consumption, and disorders of eating: a review of methods, findings and controversies. Appetite. 2018;124:78–88. https://doi.org/10.1016/j.appet.2017.03.006. Recent and updated review of rTMS and tDCS that provides a comprehensive discussion of current debates and future directions.CrossRefPubMed •• Hall PA, Vincent CM, Burhan AM. Non-invasive brain stimulation for food cravings, consumption, and disorders of eating: a review of methods, findings and controversies. Appetite. 2018;124:78–88. https://​doi.​org/​10.​1016/​j.​appet.​2017.​03.​006. Recent and updated review of rTMS and tDCS that provides a comprehensive discussion of current debates and future directions.CrossRefPubMed
40.
Zurück zum Zitat Uher R, Yoganathan D, Mogg A, Eranti SV, Treasure J, Campbell IC, et al. Effect of left prefrontal repetitive transcranial magnetic stimulation on food craving. Biol Psychiatry. 2005;58(10):840–2.CrossRef Uher R, Yoganathan D, Mogg A, Eranti SV, Treasure J, Campbell IC, et al. Effect of left prefrontal repetitive transcranial magnetic stimulation on food craving. Biol Psychiatry. 2005;58(10):840–2.CrossRef
41.
42.
Zurück zum Zitat Van den Eynde F, Claudino AM, Mogg A, Horrell L, Stahl D, Ribeiro W, et al. Repetitive transcranial magnetic stimulation reduces cue-induced food craving in bulimic disorders. Biol Psychiatry. 2010;67(8):793–5.CrossRef Van den Eynde F, Claudino AM, Mogg A, Horrell L, Stahl D, Ribeiro W, et al. Repetitive transcranial magnetic stimulation reduces cue-induced food craving in bulimic disorders. Biol Psychiatry. 2010;67(8):793–5.CrossRef
43.
Zurück zum Zitat Downar J, Sankar A, Giacobbe P, Woodside B, Colton P. Unanticipated rapid remission of refractory bulimia nervosa, during high-dose repetitive transcranial magnetic stimulation of the dorsomedial prefrontal cortex: a case report. Front Psychiatr. 2012;3:30.CrossRef Downar J, Sankar A, Giacobbe P, Woodside B, Colton P. Unanticipated rapid remission of refractory bulimia nervosa, during high-dose repetitive transcranial magnetic stimulation of the dorsomedial prefrontal cortex: a case report. Front Psychiatr. 2012;3:30.CrossRef
44.
Zurück zum Zitat Gay A, Jaussent I, Sigaud T, Billard S, Attal J, Seneque M, et al. A lack of clinical effect of high-frequency r TMS to dorsolateral prefrontal cortex on bulimic symptoms: a randomised, double-blind trial. Eur Eat Disord Rev. 2016;24(6):474–81.CrossRef Gay A, Jaussent I, Sigaud T, Billard S, Attal J, Seneque M, et al. A lack of clinical effect of high-frequency r TMS to dorsolateral prefrontal cortex on bulimic symptoms: a randomised, double-blind trial. Eur Eat Disord Rev. 2016;24(6):474–81.CrossRef
45.
Zurück zum Zitat Sutoh C, Koga Y, Kimura H, Kanahara N, Numata N, Hirano Y, et al. Repetitive transcranial magnetic stimulation changes cerebral oxygenation on the left dorsolateral prefrontal cortex in bulimia nervosa: a near-infrared spectroscopy pilot study. Eur Eat Disord Rev : J Eat Disord Assoc. 2016;24(1):83–8. https://doi.org/10.1002/erv.2413.CrossRef Sutoh C, Koga Y, Kimura H, Kanahara N, Numata N, Hirano Y, et al. Repetitive transcranial magnetic stimulation changes cerebral oxygenation on the left dorsolateral prefrontal cortex in bulimia nervosa: a near-infrared spectroscopy pilot study. Eur Eat Disord Rev : J Eat Disord Assoc. 2016;24(1):83–8. https://​doi.​org/​10.​1002/​erv.​2413.CrossRef
48.
Zurück zum Zitat •• Dalton B, Bartholdy S, McClelland J, Kekic M, Rennalls SJ, Werthmann J, et al. Randomised controlled feasibility trial of real versus sham repetitive transcranial magnetic stimulation treatment in adults with severe and enduring anorexia nervosa: the TIARA study. BMJ Open. 2018;8(7):e021531. https://doi.org/10.1136/bmjopen-2018-021531. Preliminary evidence for feasibility, patient acceptability, and efficacy of rTMS treatment for SE-AN.CrossRef •• Dalton B, Bartholdy S, McClelland J, Kekic M, Rennalls SJ, Werthmann J, et al. Randomised controlled feasibility trial of real versus sham repetitive transcranial magnetic stimulation treatment in adults with severe and enduring anorexia nervosa: the TIARA study. BMJ Open. 2018;8(7):e021531. https://​doi.​org/​10.​1136/​bmjopen-2018-021531. Preliminary evidence for feasibility, patient acceptability, and efficacy of rTMS treatment for SE-AN.CrossRef
49.
Zurück zum Zitat Lowe CJ, Hall PA, Staines WR. The effects of continuous theta burst stimulation to the left dorsolateral prefrontal cortex on executive function, food cravings, and snack food consumption. Psychosom Med. 2014;76(7):503–11.CrossRef Lowe CJ, Hall PA, Staines WR. The effects of continuous theta burst stimulation to the left dorsolateral prefrontal cortex on executive function, food cravings, and snack food consumption. Psychosom Med. 2014;76(7):503–11.CrossRef
50.
Zurück zum Zitat Bikson M, Paulus W, Esmaeilpour Z, Kronberg G, Nitsche MA. Mechanisms of acute and after effects of transcranial direct current stimulation. In: Knotkova H, Nitsche MA, Bikson M, Woods AJ, editors. Practical guide to transcranial direct current stimulation: principles, procedures and applications. Cham: Springer International Publishing; 2019. p. 81–113.CrossRef Bikson M, Paulus W, Esmaeilpour Z, Kronberg G, Nitsche MA. Mechanisms of acute and after effects of transcranial direct current stimulation. In: Knotkova H, Nitsche MA, Bikson M, Woods AJ, editors. Practical guide to transcranial direct current stimulation: principles, procedures and applications. Cham: Springer International Publishing; 2019. p. 81–113.CrossRef
54.
Zurück zum Zitat •• Ljubisavljevic M, Maxood K, Bjekic J, Oommen J, Nagelkerke N. Long-term effects of repeated prefrontal cortex transcranial direct current stimulation (tDCS) on food craving in normal and overweight young adults. Brain Stimul. 2016;9(6):826–33. https://doi.org/10.1016/j.brs.2016.07.002. Longitudinal study that showed the beneficial long-term effects of repeated tDCS to the dlPFC resulted in decreased food craving after a single session and had a significant effect which remained after 30 days.CrossRefPubMed •• Ljubisavljevic M, Maxood K, Bjekic J, Oommen J, Nagelkerke N. Long-term effects of repeated prefrontal cortex transcranial direct current stimulation (tDCS) on food craving in normal and overweight young adults. Brain Stimul. 2016;9(6):826–33. https://​doi.​org/​10.​1016/​j.​brs.​2016.​07.​002. Longitudinal study that showed the beneficial long-term effects of repeated tDCS to the dlPFC resulted in decreased food craving after a single session and had a significant effect which remained after 30 days.CrossRefPubMed
55.
Zurück zum Zitat Kekic M, McClelland J, Campbell I, Nestler S, Rubia K, David AS, et al. The effects of prefrontal cortex transcranial direct current stimulation (tDCS) on food craving and temporal discounting in women with frequent food cravings. Appetite. 2014;78:55–62.CrossRef Kekic M, McClelland J, Campbell I, Nestler S, Rubia K, David AS, et al. The effects of prefrontal cortex transcranial direct current stimulation (tDCS) on food craving and temporal discounting in women with frequent food cravings. Appetite. 2014;78:55–62.CrossRef
60.
Zurück zum Zitat • Heinitz S, Reinhardt M, Piaggi P, Weise CM, Diaz E, Stinson EJ, et al. Neuromodulation directed at the prefrontal cortex of subjects with obesity reduces snack food intake and hunger in a randomized trial. Am J Clin Nutrit. 2017;106(6):1347–57. https://doi.org/10.3945/ajcn.117.158089. Demonstrated reduced hunger ratings and ad libitum snack food consumption in satiated individuals after a longer- but not shorter-term anodal tDCS to the ldLPFC.CrossRefPubMed • Heinitz S, Reinhardt M, Piaggi P, Weise CM, Diaz E, Stinson EJ, et al. Neuromodulation directed at the prefrontal cortex of subjects with obesity reduces snack food intake and hunger in a randomized trial. Am J Clin Nutrit. 2017;106(6):1347–57. https://​doi.​org/​10.​3945/​ajcn.​117.​158089. Demonstrated reduced hunger ratings and ad libitum snack food consumption in satiated individuals after a longer- but not shorter-term anodal tDCS to the ldLPFC.CrossRefPubMed
61.
Zurück zum Zitat Jauch-Chara K, Kistenmacher A, Herzog N, Schwarz M, Schweiger U, Oltmanns KM. Repetitive electric brain stimulation reduces food intake in humans. Am J Clin Nutr. 2014;100(4):1003–9.CrossRef Jauch-Chara K, Kistenmacher A, Herzog N, Schwarz M, Schweiger U, Oltmanns KM. Repetitive electric brain stimulation reduces food intake in humans. Am J Clin Nutr. 2014;100(4):1003–9.CrossRef
62.
Zurück zum Zitat • Gluck ME, Alonso-Alonso M, Piaggi P, Weise CM, Jumpertz-von Schwartzenberg R, Reinhardt M, et al. Neuromodulation targeted to the prefrontal cortex induces changes in energy intake and weight loss in obesity. Obesity. 2015;23(11):2149–56. First study to show association of tDCS to the left dlPFC with decreased food intake and weight loss in adults with obesity.CrossRef • Gluck ME, Alonso-Alonso M, Piaggi P, Weise CM, Jumpertz-von Schwartzenberg R, Reinhardt M, et al. Neuromodulation targeted to the prefrontal cortex induces changes in energy intake and weight loss in obesity. Obesity. 2015;23(11):2149–56. First study to show association of tDCS to the left dlPFC with decreased food intake and weight loss in adults with obesity.CrossRef
65.
Zurück zum Zitat • Fassini PG, Das SK, Suen VMM, Magerowski G, Marchini JS, da Silva Junior WA, et al. Appetite effects of prefrontal stimulation depend on COMT Val158Met polymorphism: a randomized clinical trial. Appetite. 2019;140:142–50. https://doi.org/10.1016/j.appet.2019.05.015. First study to show that genotype differences impacting dopamine levels influenced prefrontal tDCS effects on appetite, concluding that inter-individual sources of variability should be considered in future studies.CrossRefPubMed • Fassini PG, Das SK, Suen VMM, Magerowski G, Marchini JS, da Silva Junior WA, et al. Appetite effects of prefrontal stimulation depend on COMT Val158Met polymorphism: a randomized clinical trial. Appetite. 2019;140:142–50. https://​doi.​org/​10.​1016/​j.​appet.​2019.​05.​015. First study to show that genotype differences impacting dopamine levels influenced prefrontal tDCS effects on appetite, concluding that inter-individual sources of variability should be considered in future studies.CrossRefPubMed
Metadaten
Titel
Brain Stimulation to Modulate Food Intake and Eating Behavior
verfasst von
Rebecca Dendy
Emma J. Stinson
Nicolas Guerithault
Marci E. Gluck
Publikationsdatum
01.12.2019
Verlag
Springer US
Erschienen in
Current Diabetes Reports / Ausgabe 12/2019
Print ISSN: 1534-4827
Elektronische ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-019-1250-2

Weitere Artikel der Ausgabe 12/2019

Current Diabetes Reports 12/2019 Zur Ausgabe

Diabetes and Pregnancy (M-F Hivert and CE Powe, Section Editors)

Sleep in Pregnancy and Maternal Hyperglycemia: a Narrative Review

Macrovascular Complications in Diabetes (VR Aroda and A Getaneh, Section Editors)

Lowering Targeted Atherogenic Lipoprotein Cholesterol Goals for Patients at “Extreme” ASCVD Risk

Other Forms of Diabetes and Its Complications (JJ Nolan and H Thabit, Section Editors)

Diabetic Gastroparesis and Glycaemic Control

Pharmacologic Treatment of Type 2 Diabetes (HE Lebovitz and G Bahtiyar, Section Editors)

Pharmacologic Randomized Clinical Trials in Prevention of Type 2 Diabetes

Microvascular Complications—Nephropathy (M Afkarian and B Roshanravan, Section Editors)

Crosstalk Between Lipids and Mitochondria in Diabetic Kidney Disease

Health Care Delivery Systems and Implementation in Diabetes (ME McDonnell and AR Sadhu, Section Editors)

Bridging the Gap for Patients with Diabetes and Cardiovascular Disease Through Cardiometabolic Collaboration

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.