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Erschienen in: Breast Cancer Research 2/2006

01.11.2006 | Oral Presentation

BRCA1 transcriptionally regulates genes associated with the basal breast cancer phenotype

verfasst von: JE Quinn, CR James, JJ Gorskii, PB Mullan, DP Harkin

Erschienen in: Breast Cancer Research | Sonderheft 2/2006

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Excerpt

Ten to twenty per cent of breast tumours exhibit a basal-like genetic profile and these tumours carry a poor prognosis. Breast tumours which contain germline mutations for BRCA1 commonly exhibit a molecular profile similar to basal breast tumours. BRCA1 is a tumour suppressor gene which is mutated in up to 5–10% of breast cancer cases and is involved in multiple cellular processes including DNA damage control, cell cycle checkpoint control, apoptosis, ubiquitination and transcriptional regulation. …
Metadaten
Titel
BRCA1 transcriptionally regulates genes associated with the basal breast cancer phenotype
verfasst von
JE Quinn
CR James
JJ Gorskii
PB Mullan
DP Harkin
Publikationsdatum
01.11.2006
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe Sonderheft 2/2006
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1547

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