Erschienen in:
01.11.2006 | Oral Presentation
BRCA1 transcriptionally regulates genes associated with the basal breast cancer phenotype
verfasst von:
JE Quinn, CR James, JJ Gorskii, PB Mullan, DP Harkin
Erschienen in:
Breast Cancer Research
|
Sonderheft 2/2006
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Excerpt
Ten to twenty per cent of breast tumours exhibit a basal-like genetic profile and these tumours carry a poor prognosis. Breast tumours which contain germline mutations for BRCA1 commonly exhibit a molecular profile similar to basal breast tumours. BRCA1 is a tumour suppressor gene which is mutated in up to 5–10% of breast cancer cases and is involved in multiple cellular processes including DNA damage control, cell cycle checkpoint control, apoptosis, ubiquitination and transcriptional regulation. …