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Supportive Care in Cancer
Erschienen in: Supportive Care in Cancer 11/2005

01.11.2005 | Review Article

Buprenorphine in cancer pain

verfasst von: Mellar P. Davis

Erschienen in: Supportive Care in Cancer | Ausgabe 11/2005

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Abstract

Buprenorphine is a broad spectrum, highly lipophilic, and long-acting partial mu opioid receptor agonist that is noncross tolerant to other opioids. Buprenorphine can be given by several routes. Metabolism is through CYP3A4 and CYP2C8 and by conjugases. Constipation and sexual dysfunction appear to be less with buprenorphine than with other opioids. The recent development of a polymer matrix patch delivery system for buprenorphine prevents “dose dumping” and facilitates pain management in those unable to take oral analgesics. Sublingual buprenorphine has been combined with naloxone to prevent illicit conversion to parenteral administration. Buprenorphine has been used extensively to control cancer pain. In certain clinical situations, buprenorphine may have particular advantages over other opioids.
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Metadaten
Titel
Buprenorphine in cancer pain
verfasst von
Mellar P. Davis
Publikationsdatum
01.11.2005
Erschienen in
Supportive Care in Cancer / Ausgabe 11/2005
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-005-0849-9

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