Background
Objectives of study
Methods
Literature search strategy
Data extraction and analysis
Epidemiology of RVGE
Rotavirus genotype combinations
Morbidity and mortality
Disease burden
Results
Literature review
Study selection
Overview of evidence available
Country | Epidemiology | Genotype combination data | Morbidity and Mortality | Disease Burden | ||||
---|---|---|---|---|---|---|---|---|
Incidence | Proportion RVGE | Seasonality | Disease severity | Mortality | Resource utilization | Costs | ||
Multic ountry* | 15**,1 6¶, 25║
| 25║,34¶,85§
| 15**,16¶,25║,36‡
| 15**,25║,3 6‡,92†,93¶
| 15**,25║,34¶
| 78††
| 15**,25║,34¶,85§
| 83¶
|
Austria | 15**,31 | 31 | 15**,31 | 62 | 31,76 | 78††
| 76 | |
Belgium | 16¶
| 34¶
| 16¶
| 93¶,94 | 81 | 78††
| 81,85§
| 81,83¶
|
Denmark | 45,96 | 36‡,12 | 95 | 78††
| 45, 85§,95,96 | 45 | ||
Finland | 23 | 78††
| 23,76§
| |||||
France | 16¶,17,20,21,25║,26,27,28 | 17,25║,34¶,26,27,28,37,38,40,41,49,97,98 | 16¶,17,20,21,25║,26,27,36‡,39,40,41,98 | 17,20,25║,36‡,63,93¶
| 17,20,26,37,38,49,79 | 17,26,78††
| 17,20,21,26,27,34¶,37,38,3 9,49,79,85§,87 | 20,21,27,38,74¶,87,98 |
Germany | 15**,1 6¶,18,25║
| 25║,34¶,42,50 | 15**,16¶,18,25║,42 | 25║,50,93¶
| 42,78††,9 9 | 34¶,42,85§
| 83¶
| |
Greece | 46,47 | 46,47 | 46 | 78††
| 46,85§
| |||
Ireland | 44 | 77 | 78††
| 44,77,85§
| 77 | |||
Italy | 16¶,19, 25║,32 | 19,25║,32,34¶,51,52, 53,100 | 16¶,19,25║,3 2,36‡,51,100 | 19,25║,51, 60,65,68,9 3¶
| 19,51, 82 | 19,32,34¶,52,82,85§
| 32,82, 83¶
| |
Netherl ands | 101 | 78††
| 85§ | |||||
Norway | 102,103 | 103 | 102 | 78††
| ||||
Portugal | 61,104 | 104 | 61,104 | 78††
| ||||
Scandinavia | 36†
| |||||||
Spain | 16¶,25║,29,30,33 | 25║,29,30,32,34¶,54,55,56 | 16¶,25║,29,30,33,36‡,54,90,105 | 25║,30,36‡, 55,64,93¶
| 29,3 0,56,78††, | 29,30,34¶,56,85§,89, 90,105 | 29,56,83¶,89, 90 | |
Sweden | 16¶
| 34¶
| 16¶
| 93¶
| 43 | 78††
| 34¶,85§
| 83¶
|
Switzerland | 15** | 15** | ||||||
UK | 16¶,25║
| 34¶,57,58,59 | 16¶,25║,36‡,57 | 25║,36‡,57,58,93¶
| 78††,106 | 34¶,85§,91, 106 | 83¶,91 |
Epidemiology of RVGE
Incidence of community-acquired RVGE
Home care setting
Incidence of nosocomial RVGE
Proportion of community-acquired RVGE
Proportion of nosocomial RVGE
Seasonality of RVGE
Rotavirus genotype combinations
Distribution of genotype combinations
Community-acquired RVGE
Nosocomial RVGE
Evolution over time of genotype combinations
Community-acquired RVGE
Nosocomial RVGE
Emerging rotavirus serotypes in Western Europe
Morbidity and mortality
Disease severity
Community-acquired RVGE
Nosocomial RVGE
Community-acquired versus nosocomial RVGE
Dehydration in community-acquired RVGE
Dehydration in community-acquired versus nosocomial RVGE
Mortality
Disease burden
Resource utilization
Community-acquired RVGE
Nosocomial RVGE
Costs
Country/Study Costs per patient | National cost estimate per year (per GDP) | |||||||
---|---|---|---|---|---|---|---|---|
Direct costs | Indirect costs | Direct costs | Indirect costs | |||||
Hospital | Primary care | Home care | Hospital | Primary care | Home care | |||
Austria
| ||||||||
Fruhwirth, 2001[66] | 384 NRV: 3,752 | NA | NA | NA | NA | NA | NA | NA |
Belgium
| ||||||||
Bilcke, 2009[67] | NA | NA | 22 | NA | NA | NA | 10,258,095 (22) | 15,372,592 (33) |
Bilcke, 2008[64] | NA | NA | 24 | NA | NA | 253 | 10,832,292 (23) | 22,448,225 (48) |
Giaquinto, 2007[68] | 2,109 | 110 | NA | 287 | 623 | NA | NA | NA |
Denmark
| ||||||||
Fischer, 2007[45] | NA | NA | NA | NA | NA | NA | 2,211,901 (7) | NA |
France
| ||||||||
Fau, 2008[20] | 44* | NA | 271* | NA | NA | NA | ||
Melliez, 2008[24] | 1,613 | 53 | 10 | NA | NA | NA | 33,829,068 (13) | NA |
Giaquinto, 2007[68] | 2,103 | 121 | NA | 260 | 377 | NA | NA | NA |
Huet, 2007[69] | NA | NA | NA | NA | NA | NA | 152,230,808 (57)†
| |
Melliez, 2005[70] | NA | NA | NA | NA | NA | NA | 35,003,757 (13) | NA |
Sermet Gaudelus, 2004[71] |
NRV: 7,185 | NA | NA | NA | NA | NA | NA | NA |
Piednoir, 2003[27] |
NRV: 4,534 | NA | NA | NA | NA | NA | NA | NA |
Germany
| ||||||||
Giaquinto, 2007[68] | 2,306 | 146 | NA | 925 | 524 | NA | NA | NA |
Ireland
| ||||||||
Harrington, 2003[60] | 1,428 NRV: 7,856 | NA | NA | NA | NA | NA | NA | NA |
Italy
| ||||||||
Marsella, 2009[72] | 2,075-2,945 | NA | NA | NA | NA | NA | NA | NA |
Panatto, 2009[65] | 2,076 | 26 | NA | NA | NA | NA | 543,775 (0.26) | 1,763,070 (0.83) |
Giaquinto, 2007[68] | 1,982 | 81 | NA | 964 | 372 | NA | NA | NA |
Spain
| ||||||||
Gil-Prieto, 2009[29] | 4,880 | NA | NA | NA | NA | NA | 53,643,376 (37) | NA |
Lopez-de- Andres, 2008[73] | 1,905 | NA | NA | NA | NA | NA | 8,967,305 (6) | NA |
Luquero Alcalde, 2008[74] | 4,505 | NA | NA | NA | NA | NA | NA | NA |
Giaquinto, 2007[68] | 1,973 | 64 | NA | 432 | 194 | NA | NA | NA |
Gil, 2004[75] | 1,838 | NA | NA | NA | NA | NA | NA | NA |
Sweden
| ||||||||
Giaquinto, 2007[68] | 2,389 | 260 | NA | 866 | 716 | NA | NA | NA |
UK
| ||||||||
Lorgelly, 2008[76] | 113 ± 203 | NA | NA | 157 ± 283 | NA | NA | NA | NA |
Giaquinto, 2007[68] | 1,942 | 141 | NA | 1,061 | 440 | NA | NA | NA |