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15.09.2017 | Original Paper

C₂₁ steroid derivatives from the Dai herbal medicine Dai-Bai-Jie, the dried roots of Marsdenia tenacissima, and their screening for anti-HIV activity

verfasst von: Xu Pang, Li-Ping Kang, Xiao-Mei Fang, He-Shui Yu, Li-Feng Han, Yang Zhao, Li-Xia Zhang, Li-Yan Yu, Bai-Ping Ma

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2018

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Abstract

Twenty-three new C₂₁ steroidal glycosides, marstenacissides C1–C10 (1–10), D1–D7 (11–17) and E1–E6 (18–23), and four new C₂₁ steroids, 11α,12β-O-ditigloyl-tenacigenin C (24), 11α-O-benzoyl-12β-O-tigloyl-tenacigenin C (25), 11α-O-tigloyl-12β-O-benzoyl-tenacigenin C (26) and 11α-O-tigloyl-12β-O-benzoyl-marsdenin (27), were isolated from the Dai herbal medicine Dai-Bai-Jie, derived from the roots of Marsdenia tenacissima. The chemical structures of all compounds were established by spectroscopic techniques, including high-resolution mass spectrometry and NMR spectroscopy, as well as by comparison with reported spectral data. The anti-HIV activities of these compounds were screened, and the compounds obtained displayed inhibitory effects against HIV-1 with inhibition rates of 36.4–81.3% at 30 μM.

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Titel: C21 steroid derivatives from the Dai herbal medicine Dai-Bai-Jie, the dried roots of Marsdenia tenacissima, and their screening for anti-HIV activity
verfasst von: Xu Pang
Li-Ping Kang
Xiao-Mei Fang
He-Shui Yu
Li-Feng Han
Yang Zhao
Li-Xia Zhang
Li-Yan Yu
Bai-Ping Ma
Publikationsdatum: 15.09.2017
Verlag: Springer Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 1/2018
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-017-1126-1

Springer Medizin

Abstract

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