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Heart Failure Reviews

Erschienen in:

01.03.2014

Calcium handling proteins: structure, function, and modulation by exercise

verfasst von: Jamille Locatelli, Leonardo V. M. de Assis, Mauro C. Isoldi

Erschienen in: Heart Failure Reviews | Ausgabe 2/2014

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Abstract

Heart failure is a serious public health issue with a growing prevalence, and it is related with the aging of the population. Hypertension is identified as the main precursor of left ventricular hypertrophy and therefore can lead to diastolic dysfunction and heart failure. Scientific studies have confirmed the beneficial effects of the physical exercise by reducing the blood pressure and improving the functional status of the heart in hypertension. Several proteins are involved in the mobilization of calcium during the coupling excitation–contraction process in the heart among those are sarcoplasmic reticulum Ca²⁺-ATPase, phospholamban, calsequestrin, sodium–calcium exchanger, L-type calcium’s channel, and ryanodine receptors. Our goal is to address the beneficial effects of exercise on the calcium handling proteins in a heart with hypertension.

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Titel: Calcium handling proteins: structure, function, and modulation by exercise
verfasst von: Jamille Locatelli
Leonardo V. M. de Assis
Mauro C. Isoldi
Publikationsdatum: 01.03.2014
Verlag: Springer US
Erschienen in: Heart Failure Reviews / Ausgabe 2/2014
Print ISSN: 1382-4147
Elektronische ISSN: 1573-7322
DOI: https://doi.org/10.1007/s10741-013-9373-z

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