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Cancer and Metastasis Reviews

Cancer and Metastasis Reviews OnlineFirst articles

14.03.2018 | NON-THEMATIC REVIEW

Developing TRAIL/TRAIL death receptor-based cancer therapies

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can initiate the apoptosis pathway by binding to its associated death receptors DR4 and DR5. The activation of the TRAIL pathway in …

13.03.2018 | NON-THEMATIC REVIEW

Pro-survival autophagy and cancer cell resistance to therapy

Resistance to therapy is one of the prime causes for treatment failure in cancer and recurrent disease. In recent years, autophagy has emerged as an important cell survival mechanism in response to different stress conditions that are associated …

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Über diese Zeitschrift

The transformation of biology from a descriptive, phenomenological discipline to one in which the regulatory principles are understood and predictably manipulated brings new opportunities to the study of cancer and the search for effective therapeutic modalities. Cancer and Metastasis Reviews offers a forum for critical review and discussion of these challenges.
Each issue presents five to seven different contributions on a single theme or topic, with an introductory essay from a distinguished individual in the field. Special emphasis is placed on subjects of relevance to the molecular and cellular biology of cancer metastasis and tumor progression, as well as to the treatment of metastatic disease. Occasional issues will be devoted to an in-depth clinical and biological analysis of a particular type of cancer.
The journal also reviews important recent developments in the biology and treatment of malignant disease, and highlights promising new directions.

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