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Cancer Chemotherapy and Pharmacology

Cancer Chemotherapy and Pharmacology OnlineFirst articles

15.02.2019 | Original Article

SCMCIE94: an intensified pilot treatment protocol known to be associated with cure in CD 56-negative non-pelvic isolated Ewing sarcoma (EWS) is also associated with no early relapses in non-metastatic extremity EWS

National and international studies conducted in the last several decades have reported improvements in the prognosis of Ewing sarcoma (EWS) using protocols with different chemotherapy agents, including actinomycin D, cyclophosphamide, vincristine …

14.02.2019 | Original Article Open Access

Gefitinib exposure and occurrence of interstitial lung disease in Japanese patients with non-small-cell lung cancer

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are a well-established therapy for the treatment of EGFR -activating mutation-positive non-small-cell lung cancer (NSCLC) [ 1 ]. EGFR TKIs are generally well-tolerated and …

13.02.2019 | Original Article

d-Dimer increase: an unfavorable factor for patients with primary liver cancer treated with TACE

As the No. 5 malignant tumor in the world, primary liver cancer (PLC) is severely malignant, with poor prognosis, and has a high incidence and mortality [ 1 ]. With a latent onset, liver cancer develops to a middle-advanced stage at definite …

13.02.2019 | Original Article

Phase I study of orally administered 14Carbon-isotope labelled-vistusertib (AZD2014), a dual TORC1/2 kinase inhibitor, to assess the absorption, metabolism, excretion, and pharmacokinetics in patients with advanced solid malignancies

Vistusertib (formerly designated AZD2014) is a highly selective, orally bioavailable inhibitor of the kinase activity of mammalian target of rapamycin (mTOR) [ 1 , 2 ], a serine/threonine kinase belonging to the phosphatidylinositol 3 kinase (PI3K) …

13.02.2019 | Original Article

Regorafenib regressed a doxorubicin-resistant Ewing’s sarcoma in a patient-derived orthotopic xenograft (PDOX) nude mouse model

Ewing’s sarcoma (ES) is an aggressive, poorly differentiated tumor derived from bone and/or soft tissue. ES is the second most common primary bone tumor, which occurs mainly in children and adolescents [ 1 ]. The overall survival (OS) of ES …

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Cancer Chemotherapy and Pharmacology addresses a wide range of pharmacologic and oncologic concerns on both experimental and clinical levels. The primary focus of this rapid publication medium is on new anticancer agents, their experimental screening, preclinical toxicology and pharmacology, single and combined drug administration modalities, and clinical phase I, II and III trials.

The journal publishes results recorded in the following areas: clinical toxicology, pharmacokinetics, pharmacodynamics, drug interactions, and indications for chemotherapy in cancer treatment strategy. Cancer Chemotherapy and Pharmacology is essential reading for pharmacologists and oncologists.

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