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Cancer Chemotherapy and Pharmacology

Cancer Chemotherapy and Pharmacology OnlineFirst articles

15.06.2018 | Original Article

Over-adherence to capecitabine: a potential safety issue in breast and colorectal cancer patients

Oral drugs are an increasingly important treatment option for cancer. Between 2006 and 2011, the use of oral anti-cancer drugs increased by 10% in the United States of America [ 1 ]. According to a French Unicancer study [ 2 ], in 2020, the …

15.06.2018 | Original Article

Pharmacokinetic and pharmacodynamic bioequivalence study of a pegfilgrastim biosimilar INTP5 in healthy subjects

Chemotherapy-induced neutropenia is one of the most common dose limiting toxicities of chemotherapy [ 1 ] and often increases the risk of serious infection and febrile neutropenia [ 2 , 3 ]. Febrile neutropenia may require hospitalisation and …

15.06.2018 | Original Article

Phase I study of the anti-α5β1 monoclonal antibody MINT1526A with or without bevacizumab in patients with advanced solid tumors

Integrins are heterodimeric cell surface receptors that mediate adhesion to the extracellular matrix. Integrin alpha 5 beta 1 (α5β1) is expressed on normal quiescent endothelial cells, but is up-regulated on endothelial cells during angiogenesis …

11.06.2018 | Clinical Trial Report

Bioequivalence study of single-dose lenalidomide capsule vs. Revlimid® capsule in healthy Chinese males

Lenalidomide is a 4-amino-glutaryl derivative of thalidomide and belongs to a new generation of immunomodulatory agents. Lenalidomide blocks the activation of the PI3K-Akt pathway, preventing the migration of endothelial cells and …

09.06.2018 | Original Article

A pharmacodynamic study of sirolimus and metformin in patients with advanced solid tumors

The mammalian target of rapamycin (mTOR) is downstream of PI3K signaling and plays a central role in cell growth, metabolism, and autophagy [ 1 ]. Upregulation of this pathway has been observed in numerous cancers including breast, lung, liver …

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Cancer Chemotherapy and Pharmacology addresses a wide range of pharmacologic and oncologic concerns on both experimental and clinical levels. The primary focus of this rapid publication medium is on new anticancer agents, their experimental screening, preclinical toxicology and pharmacology, single and combined drug administration modalities, and clinical phase I, II and III trials.

The journal publishes results recorded in the following areas: clinical toxicology, pharmacokinetics, pharmacodynamics, drug interactions, and indications for chemotherapy in cancer treatment strategy. Cancer Chemotherapy and Pharmacology is essential reading for pharmacologists and oncologists.

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