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Cancer Chemotherapy and Pharmacology

Cancer Chemotherapy and Pharmacology OnlineFirst articles

21.11.2017 | Original Article

Pharmacokinetic and toxicodynamic evaluation of oxaliplatin-induced neuropathy and hematological toxicity in rats

Oxaliplatin (L-OHP) has been developed as a third-generation platinum compound for the treatment of gastroenterological cancer in some chemotherapy regimens, including FOLFOX, CapOX, SOX, and FOLFIRINOX. Undesirable side effects, such as emesis …

21.11.2017 | Original Article

Dose and schedule modification are required for long-term continuation of sunitinib in Japanese patients with advanced pancreatic neuroendocrine tumors

Sunitinib (Sutent™, Pfizer Inc., New York, NY, USA) is an oral multi-targeted tyrosine kinases inhibitor that acts against several receptors including vascular endothelial growth factor receptors (VEGF-R) 1–3, platelet-derived growth factor …

20.11.2017 | Short Communication

The impact of skeletal muscle on the pharmacokinetics and toxicity of 5-fluorouracil in colorectal cancer

Heterogeneity exists in the ability of adults with cancer to tolerate chemotherapy. In metastatic colorectal cancer (CRC), chemotherapy is complicated by the high incidence and large individual variability in toxicity, particularly in older adults …

17.11.2017 | Original Article

Relationship between LAT1 expression and resistance to chemotherapy in pancreatic ductal adenocarcinoma

Pancreatic cancer is the leading cause of cancer death, having a dismal prognosis regardless of surgical treatment [ 1 ]. Although surgical therapy is recommended as a curative therapeutic choice, more than a half of patients with pancreatic cancer …

15.11.2017 | Original Article

The extent of ground-glass attenuation is a risk factor of chemotherapy-related exacerbation of interstitial lung disease in patients with non-small cell lung cancer

Lung cancer is the most common cause of cancer-related death worldwide. Inflammation due to interstitial lung disease (ILD) is reported to be one of the causes of lung carcinogenesis; the incidence of lung cancer in patients with ILD has been …

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Cancer Chemotherapy and Pharmacology addresses a wide range of pharmacologic and oncologic concerns on both experimental and clinical levels. The primary focus of this rapid publication medium is on new anticancer agents, their experimental screening, preclinical toxicology and pharmacology, single and combined drug administration modalities, and clinical phase I, II and III trials.

The journal publishes results recorded in the following areas: clinical toxicology, pharmacokinetics, pharmacodynamics, drug interactions, and indications for chemotherapy in cancer treatment strategy. Cancer Chemotherapy and Pharmacology is essential reading for pharmacologists and oncologists.

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