Cancer during pregnancy is relatively rare but may lead to maternal mortality. We aimed to assess the incidence of cancer related maternal mortality and the neonatal outcome in these patients. Also, doctor- and patient-related delay in cancer diagnosis and therapy among patients with cancer related maternal mortality is assessed.
Maternal mortality was defined as death during pregnancy or within 1 year after delivery. Data of the Dutch Maternal Mortality Committee was used to calculate the cancer related maternal mortality rate and to assess neonatal outcome in the Netherlands. Delay was scored by ten medical specialist based on case descriptions.
Cancer related maternal mortality rate was 1.23 per 100,000 live births. Delay in either diagnosis or treatment occurred in 65%. Delay in diagnosis was more frequent then delay in treatment, and was mainly caused by health care providers. Only 77% of pregnancies were ongoing, and 65% ended preterm of which 85% was induced.
Avoiding delay in diagnosis and therapy in case of pregnancy related cancer could potentially improve maternal and neonatal outcome. It is therefore essential to increase awareness among health care providers about the occurrence and recurrence of cancer in pregnancy and the possibilities of diagnostic and therapeutic interventions in these women.
Lee YY, Roberts CL, Dobbins T, Stavrou E, Black K, Morris J, et al. Incidence and outcomes of pregnancy-associated cancer in Australia, 1994–2008: a population-based linkage study. BJOG An Int J Obstet Gynaecol. 2012;119:1572–82. CrossRef
Schutte JM, Steegers EAP, Schuitemaker NWE, Santema JG, de Boer K, Pel M, et al. Rise in maternal mortality in the Netherlands. Br J Obstet Gynaecol. 2010;117:399–406. CrossRef
Central Bureau of Statistics of the Netherlands. Geboorte naar diverse kenmerkingen. [cited 2015 Nov 1]. Available from: http://statline.cbs.nl/StatWeb/publication/?VW=T&DM=SLNL&PA=37422ned&D1=0,4-5,7,9,11,13,17,26,35,40-41&D2=0,10,20,30,40,(l-4)-l&HD=090218-0953&HDR=G1&STB=T.
- Cancer related maternal mortality and delay in diagnosis and treatment: a case series on 26 cases
Jorine de Haan
Christianne A. R. Lok
Joke S. Schutte
Lia van Zuylen
Christianne J. M. de Groot
- BioMed Central
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