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Cardiovascular Toxicology
Erschienen in: Cardiovascular Toxicology 5/2019

29.04.2019

Carbon Monoxide Attenuates High Salt-Induced Hypertension While Reducing Pro-inflammatory Cytokines and Oxidative Stress in the Paraventricular Nucleus

verfasst von: Dong-Dong Zhang, Yan-Feng Liang, Jie Qi, Kai B. Kang, Xiao-Jing Yu, Hong-Li Gao, Kai-Li Liu, Yan-Mei Chen, Xiao-Lian Shi, Guo-Rui Xin, Li-Yan Fu, Yu-Ming Kang, Wei Cui

Erschienen in: Cardiovascular Toxicology | Ausgabe 5/2019

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Abstract

Carbon monoxide (CO) presents anti-inflammatory and antioxidant activities as a new gaseous neuromessenger produced by heme oxygenase-1 (HO-1) in the body. High salt-induced hypertension is relevant to the levels of pro-inflammatory cytokines (PICs) and oxidative stress in the hypothalamic paraventricular nucleus (PVN). We explored whether CO in PVN can attenuate high salt-induced hypertension by regulating PICs or oxidative stress. Male Dahl Salt-Sensitive rats were fed high-salt (8% NaCl) or normal-salt (0.3% NaCl) diet for 4 weeks. CORM-2, ZnPP IX, or vehicle was microinjected into bilateral PVN for 6 weeks. High-salt diet increased the levels of MAP, plasma norepinephrine (NE), reactive oxygen species (ROS), and the expressions of COX2, IL-1β, IL-6, NOX2, and NOX4 significantly in PVN (p < 0.05), but decreased the expressions of HO-1 and Cu/Zn-SOD in PVN (p < 0.05). Salt increased sympathetic activity as measured by circulating norepinephrine, and increased the ratio of basal RSNA to max RSNA, in part by decreasing max RSNA. PVN microinjection of CORM-2 decreased the levels of MAP, NE, RSNA, ROS and the expressions of COX2, IL-1β, IL-6, NOX2, NOX4 significantly in PVN of hypertensive rat (p < 0.05), but increased the expressions of HO-1 and Cu/Zn-SOD significantly (p < 0.05), which were all opposite to the effects of ZnPP IX microinjected in PVN (p < 0.05). We concluded that exogenous or endogenous CO attenuates high salt-induced hypertension by regulating PICs and oxidative stress in PVN.
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Literatur
1.
Frohlich, E. D., & Varagic, J. (2005). Sodium directly impairs target organ function in hypertension. Curr Opin Cardiol, 20, 424–429.CrossRefPubMed
2.
3.
Yu, X. J., Suo, Y. P., Qi, J., Yang, Q., Li, H. H., Zhang, D. M., et al. (2013). Interaction between AT1 receptor and NF-kappaB in hypothalamic paraventricular nucleus contributes to oxidative stress and sympathoexcitation by modulating neurotransmitters in heart failure. Cardiovasc Toxicol, 13, 381–390.CrossRefPubMed
4.
Su, Q., Qin, D. N., Wang, F. X., Ren, J., Li, H. B., Zhang, M., et al. (2014). Inhibition of reactive oxygen species in hypothalamic paraventricular nucleus attenuates the renin-angiotensin system and proinflammatory cytokines in hypertension. Toxicol Appl Pharmacol, 276, 115–120.CrossRefPubMed
5.
Cardinale, J. P., Sriramula, S., Mariappan, N., Agarwal, D., & Francis, J. (2012). Angiotensin II-induced hypertension is modulated by nuclear factor-kappaBin the paraventricular nucleus. Hypertension, 59, 113–121.CrossRefPubMed
6.
Kang, Y. M., Zhang, D. M., Yu, X. J., Yang, Q., Qi, J., Su, Q., et al. (2014). Chronic infusion of enalaprilat into hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension and cardiac hypertrophy by restoring neurotransmitters and cytokines. Toxicol Appl Pharmacol, 274, 436–444.CrossRefPubMed
7.
Swanson, L. W., & Sawchenko, P. E. (1980). Paraventricular nucleus: a site for the integration of neuroendocrine and autonomic mechanisms. Neuroendocrinology, 31, 410–417.CrossRefPubMed
8.
Levitt, D. G., & Levitt, M. D. (2015). Carbon monoxide: a critical quantitative analysis and review of the extent and limitations of its second messenger function. Clin Pharmacol, 7, 37–56.PubMedPubMedCentral
9.
Maines, M. D. (1997). The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol, 37, 517–554.CrossRefPubMed
10.
Ewing, J. F., & Maines, M. D. (1992). In situ hybridization and immunohistochemical localization of heme oxygenase-2 mRNA and protein in normal rat brain: differential distribution of isozyme 1 and 2. Mol Cell Neurosci, 3, 559–570.CrossRefPubMed
11.
Vincent, S. R., Das, S., & Maines, M. D. (1994). Brain heme oxygenase isoenzymes and nitric oxide synthase are co-localized in select neurons. Neuroscience, 63, 223–231.CrossRefPubMed
12.
Leffler, C. W., Parfenova, H., & Jaggar, J. H. (2011). Carbon monoxide as an endogenous vascular modulator. Am J Physiol Heart Circ Physiol, 301, H1–H11.CrossRefPubMedPubMedCentral
13.
Granger, J. P. (2006). An emerging role for inflammatory cytokines in hypertension. Am J Physiol Heart Circ Physiol, 290, H923–H924.CrossRefPubMed
14.
Guzik, T. J., & Touyz, R. M. (2017). Oxidative stress, inflammation, and vascular aging in hypertension. Hypertension, 70, 660–667.CrossRefPubMed
15.
Naregal, G. V., Devaranavadagi, B. B., Patil, S. G., & Aski, B. S. (2017). Elevation of oxidative stress and decline in endogenous antioxidant defense in elderly individuals with hypertension. J Clin Diagn Res, 11, BC09–BC12.PubMedPubMedCentral
16.
Harayama, S., Kok, M., & Neidle, E. L. (1992). Functional and evolutionary relationships among diverse oxygenases. Annu Rev Microbiol, 46, 565–601.CrossRefPubMed
17.
Bai, J., Yu, X. J., Liu, K. L., Wang, F. F., Jing, G. X., Li, H. B., et al. (2017). Central administration of tert-butylhydroquinone attenuates hypertension via regulating Nrf2 signaling in the hypothalamic paraventricular nucleus of hypertensive rats. Toxicol Appl Pharmacol, 333, 100–109.CrossRefPubMed
18.
Liang, Y. F., Zhang, D. D., Yu, X. J., Gao, H. L., Liu, K. L., Qi, J., et al. (2017). Hydrogen sulfide in paraventricular nucleus attenuates blood pressure by regulating oxidative stress and inflammatory cytokines in high salt-induced hypertension. Toxicol Lett, 270, 62–71.CrossRefPubMed
19.
Gorojod, R. M., Alaimo, A., Porte Alcon, S., Martinez, J. H., Cortina, M. E., Vazquez, E. S., et al. (2018). Heme oxygenase-1 protects astroglia against manganese-induced oxidative injury by regulating mitochondrial quality control. Toxicol Lett, 295, 357–368.CrossRefPubMed
20.
Berne, J. P., Lauzier, B., Rochette, L., & Vergely, C. (2012). Carbon monoxide protects against ischemia-reperfusion injury in vitro via antioxidant properties. Cell Physiol Biochem, 29, 475–484.CrossRefPubMed
21.
Parfenova, H., Leffler, C. W., Basuroy, S., Liu, J., & Fedinec, A. L. (2012). Antioxidant roles of heme oxygenase, carbon monoxide, and bilirubin in cerebral circulation during seizures. J Cereb Blood Flow Metab, 32, 1024–1034.CrossRefPubMedPubMedCentral
22.
Lian, S., Xia, Y., Ung, T. T., Khoi, P. N., Yoon, H. J., Kim, N. H., et al. (2016). Carbon monoxide releasing molecule-2 ameliorates IL-1beta-induced IL-8 in human gastric cancer cells. Toxicology, 361–362, 24–38.CrossRefPubMed
23.
Bauer, B., Goderz, A. L., Braumuller, H., Neudorfl, J. M., Rocken, M., Wieder, T., et al. (2017). Methyl fumarate-derived iron carbonyl complexes (FumET-CORMs) as powerful anti-inflammatory agents. ChemMedChem, 12, 1927–1930.CrossRefPubMed
24.
Choi, S., Kim, J., Kim, J. H., Lee, D. K., Park, W., Park, M., et al. (2017). Carbon monoxide prevents TNF-alpha-induced eNOS downregulation by inhibiting NF-kappaB-responsive miR-155-5p biogenesis. Exp Mol Med, 49, e403.CrossRefPubMedPubMedCentral
25.
Lin, C. C., Yang, C. C., Hsiao, L. D., Chen, S. Y., & Yang, C. M. (2017). Heme oxygenase-1 induction by carbon monoxide releasing molecule-3 suppresses interleukin-1 beta-mediated neuroinflammation. Front Mol Neurosci, 10, 387.CrossRefPubMedPubMedCentral
26.
Sun, Q., Wu, Y., Zhao, F., & Wang, J. (2017). Maresin 1 ameliorates lung ischemia/reperfusion injury by suppressing oxidative stress via activation of the Nrf-2-mediated HO-1 signaling pathway. Oxid Med Cell Longev, 2017, 9634803.PubMedPubMedCentral
27.
Stocker, R., McDonagh, A. F., Glazer, A. N., & Ames, B. N. (1990). Antioxidant activities of bile pigments: biliverdin and bilirubin. Methods Enzymol, 186, 301–309.CrossRefPubMed
28.
Chen, W., Maghzal, G. J., Ayer, A., Suarna, C., Dunn, L. L., & Stocker, R. (2018). Absence of the biliverdin reductase-a gene is associated with increased endogenous oxidative stress. Free Radic Biol Med, 115, 156–165.CrossRefPubMed
29.
Nassar, N. N., Li, G., Strat, A. L., & Abdel-Rahman, A. A. (2011). Enhanced hemeoxygenase activity in the rostral ventrolateral medulla mediates exaggerated hemin-evoked hypotension in the spontaneously hypertensive rat. J Pharmacol Exp Ther, 339, 267–274.CrossRefPubMedPubMedCentral
30.
Fouda, M. A., El-Gowelli, H. M., El-Gowilly, S. M., Rashed, L., & El-Mas, M. M. (2014). Impairment of nitric oxide synthase but not heme oxygenase accounts for baroreflex dysfunction caused by chronic nicotine in female rats. PLoS ONE, 9, e98681.CrossRefPubMedPubMedCentral
31.
Qi, J., Zhang, D. M., Suo, Y. P., Song, X. A., Yu, X. J., Elks, C., et al. (2013). Renin-angiotensin system modulates neurotransmitters in the paraventricular nucleus and contributes to angiotensin II-induced hypertensive response. Cardiovasc Toxicol, 13, 48–54.CrossRefPubMed
32.
Li, H. B., Qin, D. N., Ma, L., Miao, Y. W., Zhang, D. M., Lu, Y., et al. (2014). Chronic infusion of lisinopril into hypothalamic paraventricular nucleus modulates cytokines and attenuates oxidative stress in rostral ventrolateral medulla in hypertension. Toxicol Appl Pharmacol, 279, 141–149.CrossRefPubMed
33.
Zhang, M., Qin, D. N., Suo, Y. P., Su, Q., Li, H. B., Miao, Y. W., et al. (2015). Endogenous hydrogen peroxide in the hypothalamic paraventricular nucleus regulates neurohormonal excitation in high salt-induced hypertension. Toxicol Lett, 235, 206–215.CrossRefPubMed
34.
Kang, Y. M., Gao, F., Li, H. H., Cardinale, J. P., Elks, C., Zang, W. J., et al. (2011). NF-kappaB in the paraventricular nucleus modulates neurotransmitters and contributes to sympathoexcitation in heart failure. Basic Res Cardiol, 106, 1087–1097.CrossRefPubMedPubMedCentral
35.
Kagota, S., Tamashiro, A., Yamaguchi, Y., Nakamura, K., & Kunitomo, M. (2002). High salt intake impairs vascular nitric oxide/cyclic guanosine monophosphate system in spontaneously hypertensive rats. J Pharmacol Exp Ther, 302, 344–351.CrossRefPubMed
36.
Johnson, R. A., Colombari, E., Colombari, D. S., Lavesa, M., Talman, W. T., & Nasjletti, A. (1997). Role of endogenous carbon monoxide in central regulation of arterial pressure. Hypertension, 30, 962–967.CrossRefPubMed
37.
Lo, W. C., Jan, C. R., Chiang, H. T., & Tseng, C. J. (2000). Modulatory effects of carbon monoxide on baroreflex activation in nucleus tractus solitarii of rats. Hypertension, 35, 1253–1257.CrossRefPubMed
38.
Lo, W. C., Chan, J. Y., Tung, C. S., & Tseng, C. J. (2002). Carbon monoxide and metabotropic glutamate receptors in rat nucleus tractus solitarii: participation in cardiovascular effect. Eur J Pharmacol, 454, 39–45.CrossRefPubMed
39.
Lin, C. H., Lo, W. C., Hsiao, M., & Tseng, C. J. (2003). Interaction of carbon monoxide and adenosine in the nucleus tractus solitarii of rats. Hypertension, 42, 380–385.CrossRefPubMed
40.
Johnson, R. A., Lavesa, M., DeSeyn, K., Scholer, M. J., & Nasjletti, A. (1996). Heme oxygenase substrates acutely lower blood pressure in hypertensive rats. Am J Physiol, 271, H1132–H1138.PubMed
41.
Johnson, R. A., Lavesa, M., Askari, B., Abraham, N. G., & Nasjletti, A. (1995). A heme oxygenase product, presumably carbon monoxide, mediates a vasodepressor function in rats. Hypertension, 25, 166–169.CrossRefPubMed
42.
Bolognesi, M., Sacerdoti, D., Piva, A., Di Pascoli, M., Zampieri, F., Quarta, S., et al. (2007). Carbon monoxide-mediated activation of large-conductance calcium-activated potassium channels contributes to mesenteric vasodilatation in cirrhotic rats. J Pharmacol Exp Ther, 321, 187–194.CrossRefPubMed
43.
Wang, M. L., Yu, X. J., Li, X. G., Pang, D. Z., Su, Q., Saahene, R. O., et al. (2018). Blockade of TLR4 within the paraventricular nucleus attenuates blood pressure by regulating ROS and inflammatory cytokines in prehypertensive rats. Am J Hypertens, 31, 1013–1023.CrossRefPubMed
44.
Kang, Y. M., Yang, Q., Yu, X. J., Qi, J., Zhang, Y., Li, H. B., et al. (2014). Hypothalamic paraventricular nucleus activation contributes to neurohumoral excitation in rats with heart failure. Regen Med Res, 2, 2.CrossRefPubMedPubMedCentral
45.
Shi, P., Diez-Freire, C., Jun, J. Y., Qi, Y., Katovich, M. J., Li, Q., et al. (2010). Brain microglial cytokines in neurogenic hypertension. Hypertension, 56, 297–303.CrossRefPubMedPubMedCentral
46.
Sriramula, S., Cardinale, J. P., & Francis, J. (2013). Inhibition of TNF in the brain reverses alterations in RAS components and attenuates angiotensin II-induced hypertension. PLoS ONE, 8, e63847.CrossRefPubMedPubMedCentral
47.
Qi, J., Zhao, X. F., Yu, X. J., Yi, Q. Y., Shi, X. L., Tan, H., et al. (2016). Targeting interleukin-1 beta to suppress sympathoexcitation in hypothalamic paraventricular nucleus in Dahl salt-sensitive hypertensive rats. Cardiovasc Toxicol, 16, 298–306.CrossRefPubMed
48.
Ho, Y. H., Lin, Y. T., Wu, C. W., Chao, Y. M., Chang, A. Y., & Chan, J. Y. (2015). Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus. J Biomed Sci, 22, 46.CrossRefPubMedPubMedCentral
49.
Wei, S. G., Yu, Y., & Felder, R. B. (2018). Blood-borne interleukin-1beta acts on the subfornical organ to upregulate the sympathoexcitatory milieu of the hypothalamic paraventricular nucleus. Am J Physiol Regul Integr Comp Physiol, 314, R447–R458.CrossRefPubMed
50.
Qi, J., Yu, X. J., Shi, X. L., Gao, H. L., Yi, Q. Y., Tan, H., et al. (2016). NF-kappaB blockade in hypothalamic paraventricular nucleus inhibits high-salt-induced hypertension through NLRP3 and Caspase-1. Cardiovasc Toxicol, 16, 345–354.CrossRefPubMed
51.
Kang, Y. M., He, R. L., Yang, L. M., Qin, D. N., Guggilam, A., Elks, C., et al. (2009). Brain tumour necrosis factor-alpha modulates neurotransmitters in hypothalamic paraventricular nucleus in heart failure. Cardiovasc Res, 83, 737–746.CrossRefPubMedPubMedCentral
52.
Li, H. B., Qin, D. N., Cheng, K., Su, Q., Miao, Y. W., Guo, J., et al. (2015). Central blockade of salusin beta attenuates hypertension and hypothalamic inflammation in spontaneously hypertensive rats. Sci Rep, 5, 11162.CrossRefPubMedPubMedCentral
Metadaten
Titel
Carbon Monoxide Attenuates High Salt-Induced Hypertension While Reducing Pro-inflammatory Cytokines and Oxidative Stress in the Paraventricular Nucleus
verfasst von
Dong-Dong Zhang
Yan-Feng Liang
Jie Qi
Kai B. Kang
Xiao-Jing Yu
Hong-Li Gao
Kai-Li Liu
Yan-Mei Chen
Xiao-Lian Shi
Guo-Rui Xin
Li-Yan Fu
Yu-Ming Kang
Wei Cui
Publikationsdatum
29.04.2019
Verlag
Springer US
Erschienen in
Cardiovascular Toxicology / Ausgabe 5/2019
Print ISSN: 1530-7905
Elektronische ISSN: 1559-0259
DOI
https://doi.org/10.1007/s12012-019-09517-w

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