Background
Methods
Study population
Questionnaire survey on cardiovascular diseases and risk factors
Validation study: The general practitioner questionnaire
Statistical analysis
Results
Validation sample and patients’ characteristics
Clinical characteristic | No Denied Consent | Yes Gave consent | |
---|---|---|---|
Age at breast cancer diagnosis (years) | mean SDa | 58.6 11.6 | 55.2 10.6 |
Age at questionnairesurvey (years) | Mean SD | 69.4 11.7 | 65.9 10.7 |
Follow-up (years) | median | 9.62 | 9.17 |
T-stage (N, %) | 0/1 2 3 4 In situ Unknown | 507 (53.7%) 264 (27.9%) 35 (3.7%) 30 (3.2%) 88 (9.3%) 21 (2.2%) | 727 (55.2%) 380 (28.9%) 39 (3.0%) 25 (1.9%) 109 (8.3%) 36 (2.7%) |
N-stage (N, %) | 0 1 2 3 X | 587 (62.1%) 217 (23.0%) 38 (4.0%) 27 (2.9%) 76 (8.0%) | 829 (63.0%) 318 (24.2%) 58 (4.4%) 29 (2.2%) 82 (6.2%) |
Chemotherapy (N, %) | Yes No Unknown | 515 (54.5%) 399 (42.2%) 31 (3.3%) | 604 (45.9%) 671 (51.0%) 41 (3.1%) |
Radiotherapy (N,%) | Yes No Unknown | 737 (78.0%) 166 (17.6%) 42 (4.4%) | 1090 (82.8%) 174 (13.2%) 52 (4.0%) |
Type of surgery (N, %) | None Breast conserving Mastectomy Unknown | 3 (0.3%) 751 (79.5%) 190 (20.1%) 1 (0.1%) | 8 (0.6%) 1067 (81.1%) 241 (18.3%) 0 (0.0%) |
History of cardiac event (N, %) | Yes No | 174 (18.4%) 771 (81.6%) | 220 (16.7%) 1096 (83.3%) |
Total N = 2261 | 945 | 1316 |
Agreement for cardiac endpoints
GPa: negative n (%) | GP: positive n (%) | All N (%) | |
---|---|---|---|
Patients questionnaire: negative | 950 (90%) | 105 (10%) | 1055 (100%) |
Patients questionnaire: positive | 83 (53%) | 74 (47%) | 157 (100% |
Disease | GPa, negative Pb negative (Agreement) | GP, positive P positive (Agreement) | GP positive P negative (Underreporters) | GP negative P positive (Overreporters) | Kappa | CCRc |
---|---|---|---|---|---|---|
Stroke | 968 (96.9%) | 14 (1.40%) | 7 (0.70%) | 10 (1.00%) | 0.61 | 98.3% |
Myocardial infarction | 1003 (99.2%) | 3 (0.30%) | 1 (0.10%) | 4 (0.40%) | 0.54 | 99.5% |
Angina pectoris | 935 (95.0%) | 14 (1.42%) | 28 (2.83%) | 11 (1.11%) | 0.40 | 96.1% |
Valvular heart disease | 913 (93.7%) | 16 (1.64%) | 34 (3.50%) | 11 (1.13%) | 0.39 | 95.4% |
Arrythmia | 836 (88.8%) | 27 (2.87%) | 41 (4.36%) | 37 (3.93%) | 0.37 | 91.7% |
Congestive heart failure | 905 (93.5%) | 14 (1.45%) | 21 (2.17%) | 28 (2.89%) | 0.34 | 94.9% |
Determinants for the agreement regarding any cardiac event
Agreement for cardiovascular risk factors
Disease | GPa, negative P negative (Agreement) | GP, positive P positive (Agreement) | GP negative P positive (Overreporters) | GP positive P negative (Underreporters) | Kappa | CCRb |
---|---|---|---|---|---|---|
Diabetes mellitus | 866 (86.3%) | 93 (9.26%) | 7 (0.70%) | 38 (3.79%) | 0.78 | 95.5% |
Hypertension | 492 (49.0%) | 370 (36.9%) | 53 (5.28%) | 89 (8.86%) | 0.71 | 85.9% |
Thyroid functional disease | 508 (50.5%) | 315 (31.3%) | 134 (13.3%) | 49 (4.87%) | 0.62 | 81.7% |
COPD | 839 (84.0%) | 72 (7.21%) | 51 (5.11%) | 36 (3.61%) | 0.57 | 91.3% |
Hyper-Cholesteremia | 395 (40.3% | 294 (30.0%) | 99 (10.1%) | 193 (19.7%) | 0.40 | 70.2% |
Chronic kidney disease | 905 (93.1%) | 18 (1.90%) | 18 (1.90%) | 31 (3.20%) | 0.40 | 95.0% |