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17.04.2017 | Original Article

Cardiorespiratory fitness and muscle strength in pancreatic cancer patients

verfasst von: Dorothea Clauss, Christine Tjaden, Thilo Hackert, Lutz Schneider, Cornelia M. Ulrich, Joachim Wiskemann, Karen Steindorf

Erschienen in: Supportive Care in Cancer | Ausgabe 9/2017

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Abstract

Purpose

Cancer patients frequently experience reduced physical fitness due to the disease itself as well as treatment-related side effects. However, studies on physical fitness in pancreatic cancer patients are missing. Therefore, we assessed cardiorespiratory fitness and muscle strength of pancreatic cancer patients.

Methods

We included 65 pancreatic cancer patients, mostly after surgical resection. Cardiorespiratory fitness was assessed using cardiopulmonary exercise testing (CPET) and 6-min walk test (6MWT). Hand-held dynamometry was used to evaluate isometric muscle strength. Physical fitness values were compared to reference values of a healthy population. Associations between sociodemographic and clinical variables with patients’ physical fitness were analyzed using multiple regression models.

Results

Cardiorespiratory fitness (VO₂peak, 20.5 ± 6.9 ml/min/kg) was significantly lower (−24%) compared to healthy reference values. In the 6MWT pancreatic cancer patients nearly reached predicted values (555 vs. 562 m). Maximal voluntary isometric contraction (MVIC) of the upper (−4.3%) and lower extremities (−13.8%) were significantly lower compared to reference values. Overall differences were larger in men than those in women. Participating in regular exercise in the year before diagnosis was associated with greater VO₂peak (p < .05) and MVIC of the knee extensors (p < .05).

Conclusions

Pancreatic cancer patients had significantly impaired physical fitness with regard to both cardiorespiratory function and isometric muscle strength, already in the early treatment phase (median 95 days after surgical resection). Our findings underline the need to investigate exercise training in pancreatic cancer patients to counteract the loss of physical fitness.

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Titel: Cardiorespiratory fitness and muscle strength in pancreatic cancer patients
verfasst von: Dorothea Clauss
Christine Tjaden
Thilo Hackert
Lutz Schneider
Cornelia M. Ulrich
Joachim Wiskemann
Karen Steindorf
Publikationsdatum: 17.04.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 9/2017
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-017-3694-8

Springer Medizin

Cardiorespiratory fitness and muscle strength in pancreatic cancer patients