The authors declare that they have no competing interests.
SH conceived the study, performed statistical analysis and drafted the manuscript. IO conceived the study, performed statistical analysis and drafted the manuscript. AS conceived the study, participated in its design and helped to draft the manuscript. MP, IH and YS participated in its design and helped to draft the manuscript. MN conceived the study, participated in its design and coordination, and helped to draft the manuscript. All authors read and approved the final manuscript.
Ankylosing spondylitis (AS) is an inflammatory disease with documented elevated cardiovascular (CV) risk due to systemic inflammation and a higher prevalence of CV risk factors. CV risk management (CV-RM) could be an effective method to reduce CV mortality and morbidity in AS patients. We assessed CV risk and evaluated guideline adherence according to the Dutch CV-RM guideline.
This study was conducted with a cohort of consecutive AS patients eligible for treatment with a tumor necrosis factor (TNF) -α inhibitor. Data from the Dutch National Institute for Public Health and Environment was used to compare the prevalence of CV risk factors in AS patients with the Dutch background population.
In total, 254 consecutive AS patients were included. The prevalences of hypertension (41% vs 31%) and smoking (43% vs 27%) were substantially higher in AS patients as compared to the general Dutch background population. Of 138 AS patients older than 40 years the 10-years CV risk could be calculated. Fifty-one of these 138 patients (37%) had an indication for CV risk treatment. CV risk treatment was initiated in 42 of the 51 (82%), however, in only 12 of the 51 (24%) patients treatment targets for either hypertension or hypercholesterolemia were reached.
The increased rates of hypertension and smoking illustrate the importance of CV-RM in AS patients. Although the majority of all AS patients eligible for CV-RM received CV risk medication, CV-RM remains a challenge for treating physicians, as treatment targets were not achieved in three-quarter of the eligible patients.
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- Cardiovascular risk management in patients with active Ankylosing Spondylitis: a detailed evaluation
Sjoerd C Heslinga
Inge A Van den Oever
Alper M Van Sijl
Mike J Peters
Irene E Van der Horst-Bruinsma
Yvo M Smulders
Michael T Nurmohamed
- BioMed Central
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