Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Breast Cancer Research
Erschienen in: Breast Cancer Research 2/2000

01.04.2000 | Commentary

Caretaker Brca1: keeping the genome in the straight and narrow

verfasst von: Veronica Yu

Erschienen in: Breast Cancer Research | Ausgabe 2/2000

Einloggen, um Zugang zu erhalten

Abstract

Inheritance of germline BRCA1 mutations is associated with a high risk of breast and ovarian cancers. A multitude of cellular functions has been ascribed to BRCA1, including transcription activation and various aspects of DNA repair. So far, indirect evidence has indicated a role for BRCA1 in the repair of double-strand breaks. Recently, an elegant gene targeting design was used to provide definitive evidence that BRCA1 promotes homologous recombination and limits nonhomologous mutagenic repair processes. This reaffirms the role of BRCA1 as caretaker in preserving genomic integrity.
Literatur
1.
Rajan JV, Wang M, Marquis ST, Chodosh LA: Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells. Proc Natl Acad Sci USA. 1996, 93: 13078-13083. 10.1073/pnas.93.23.13078.CrossRefPubMedPubMedCentral
2.
Chapman MS, Verma IM: Transcriptional activation by BRCA1. Nature. 1996, 382: 678-679. 10.1038/382678a0.CrossRefPubMed
3.
Anderson SF, Schlegel BP, Nakajima T, Wolpin ES, Parvin JD: BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Nature Genet. 1998, 19: 254-256. 10.1038/930.CrossRefPubMed
4.
Milner J, Ponder B, Hughes-Davies L, Seltmann M, Kouzarides T: Transcriptional activation functions in BRCA2 [letter]. Nature. 1997, 386: 772-773. 10.1038/386772a0.CrossRefPubMed
5.
Yarden RI, Brody LC: BRCA1 interacts with components of the histone deacetylase complex. Proc Natl Acad Sci USA. 1999, 96: 4983-4988. 10.1073/pnas.96.9.4983.CrossRefPubMedPubMedCentral
6.
Fuks F, Milner J, Kouzarides T: BRCA2 associates with acetyltransferase activity when bound to P/CAF. Oncogene. 1998, 17: 2531-2534. 10.1038/sj.onc.1202475.CrossRefPubMed
7.
Xu XL, Weaver Z, Linke SP, et al: Centrosome amplication and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon11 isoform-deficient cells. Mol Cell. 1999, 3: 389-395.CrossRefPubMed
8.
Tutt A, Gabriel A, Bertwistle D, et al: Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification. Curr Biol. 1999, 9: 1107-1110. 10.1016/S0960-9822(99)80479-5.CrossRefPubMed
9.
Harkin DP, Bean JM, Miklos D, et al: Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1. Cell. 1999, 97: 575-586. 10.1016/S0092-8674(00)80769-2.CrossRefPubMed
10.
Gowen LC, Avrutskaya AV, Latour AM, Koller BH, Leadon SA: BRCA1 required for transcription-coupled repair of oxidative DNA damage. Science. 1998, 281: 1009-1012. 10.1126/science.281.5379.1009.CrossRefPubMed
11.
Shen SX, Weaver Z, Xu XL, et al: A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene. 1998, 17: 3115-3124. 10.1038/sj.onc.1202243.CrossRefPubMed
12.
Moynahan ME, Chiu JW, Koller BH, Jasin M: Brca1 controls homology-directed DNA repair. Mol Cell. 1999, 4: 511-518.CrossRefPubMed
13.
Patel KJ, Yu VP, Lee H, et al: Involvement of Brca2 in DNA repair. Mol Cell. 1998, 1: 347-357.CrossRefPubMed
14.
Gowen LC, Johnson BL, Latour AM, Sulik KK, Koller BH: Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nature Genet. 1996, 12: 191-194.CrossRefPubMed
15.
Liu CY, Flesken-Nikitin A, Li S, Zeng Y, Lee WH: Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes Dev. 1996, 10: 1835-1843.CrossRefPubMed
16.
Hakem R, de la Pompa JL, Sirard C, et al: The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell. 1996, 85: 1009-1023. 10.1016/S0092-8674(00)81302-1.CrossRefPubMed
17.
Sharan SK, Morimatsu M, Albrecht U, et al: Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature. 1997, 386: 804-810. 10.1038/386804a0.CrossRefPubMed
18.
Ludwig T, Chapman DL, Papaioannou VE, Efstratiadis A: Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev. 1997, 11: 1226-1241.CrossRefPubMed
19.
Wong AKC, Pero R, Ormonde PA, Tavtigian SV, Bartel PL: RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2. J Biol Chem. 1997, 272: 31941-31944. 10.1074/jbc.272.51.31941.CrossRefPubMed
20.
Scully R, Chen J, Plug A, et al: Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell. 1997, 88: 265-275.CrossRefPubMed
21.
Chen JJ, Silver DP, Walpita D, et al: Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell. 1998, 2: 317-328.CrossRefPubMed
22.
Scully R, Chen JJ, Ochs RL, et al: Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell. 1997, 90: 425-435.CrossRefPubMed
23.
Liang F, Han M, Romanienko PJ, Jasin M: Homology-directed repair is a major double-strand break repair pathway in mammalian cells. Proc Natl Acad Sci USA. 1998, 95: 5172-5177. 10.1073/pnas.95.9.5172.CrossRefPubMedPubMedCentral
24.
Critchlow SE, Jackson SP: DNA end-joining: from yeast to man. Trends Biochem Sci. 1998, 23: 394-398. 10.1016/S0968-0004(98)01284-5.CrossRefPubMed
25.
Jasin M: Genetic manipulation of genomes with rare-cutting endonucleases. Trends Genet. 1996, 12: 224-228. 10.1016/0168-9525(96)10019-6.CrossRefPubMed
26.
Colleaux L, d'Auriol L, Betermier M, et al: Universal code equivalent of a yeast mitochondrial intron reading frame is expressed into E. coli as a specific double strand endonuclease. Cell. 1986, 44: 521-533.CrossRefPubMed
27.
Chen C, Umezu K, Kolodner RD: Chromosomal rearrangements occur in S-cerevisiae rfa1 mutator mutants due to mutagenic lesions processed by double-strand-break repair. Mol Cell. 1998, 2: 9-22.CrossRefPubMed
28.
Chen C, Kolodner RD: Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants. Nature Genet. 1999, 23: 81-85. 10.1038/14281.CrossRefPubMed
29.
Tomlinson G, Chen TT, Stastny VA, et al: Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier. Cancer Res. 1998, 58: 3237-3242.PubMed
30.
Meyn MS: Chromosome instability syndromes: lessons for carcinogenesis. Curr Top Microbiol Immunol. 1997, 221: 71-148.PubMed
31.
Kinzler KW, Vogelstein B: Cancer-susceptibility genes. Gatekeepers and caretakers [news]. Nature. 1997, 386: 761-763. 10.1038/386761a0.CrossRefPubMed
32.
Zhong Q, Chen CF, Li S, et al: Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. Science. 1999, 285: 747-750. 10.1126/science.285.5428.747.CrossRefPubMed
33.
Cortez D, Wang Y, Qin J, Elledge SJ: Requirement of ATM dependent phosphorylation of Brca1 in the DNA damage response to double-strand breaks. Science. 1999, 286: 1162-1166. 10.1126/science.286.5442.1162.CrossRefPubMed
34.
Venkitaraman AR: Breast cancer genes and DNA repair. Science. 1999, 286: 1100-1102. 10.1126/science.286.5442.1100.CrossRefPubMed
35.
Pierce AJ, Johnson RD, Thompson LH, Jasin M: XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev. 1999, 13: 2633-2638. 10.1101/gad.13.20.2633.CrossRefPubMedPubMedCentral
36.
Johnson RD, Jasin M: Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination. Nature. 1999, 401: 397-399. 10.1038/43935.PubMed
37.
Jones NJ, Cox R, Thacker J: Isolation and cross-sensitivity of X-ray sensitive mutants of V79-4 hamster cells. Mutat Res. 1987, 183: 279-286. 10.1016/0167-8817(87)90011-3.PubMed
38.
Liu N, Lamerdin JE, Tebbs RS, et al: XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. Mol Cell. 1998, 1: 783-793.CrossRefPubMed
39.
Kemp LM, Jeggo PA: Radiation-induced chromosome damage in X-ray-sensitive mutants (xrs) of the Chinese hamster ovary cell line. Mutat Res. 1986, 166: 255-263. 10.1016/0167-8817(86)90025-8.PubMed
Metadaten
Titel
Caretaker Brca1: keeping the genome in the straight and narrow
verfasst von
Veronica Yu
Publikationsdatum
01.04.2000
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 2/2000
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr37

Weitere Artikel der Ausgabe 2/2000

Breast Cancer Research 2/2000 Zur Ausgabe

Review

Transforming growth factor-β and breast cancer: Cell cycle arrest by transforming growth factor-β and its disruption in cancer

Research article

Increased cell survival by inhibition of BRCA1 using an antisense approach in an estrogen responsive ovarian carcinoma cell line

Review

Transforming growth factor-β and breast cancer: Introduction

Review

Transforming growth factor-β and breast cancer: Mammary gland development

Meeting report

22nd Annual San Antonio Breast Cancer Symposium, 8-11 December 1999, San Antonio, Texas, USA

Review

Signal transducers and activators of transcription as regulators of growth, apoptosis and breast development

Neu im Fachgebiet Onkologie

Umsetzung der POMGAT-Leitlinie läuft

03.05.2024 DCK 2024 Kongressbericht

Seit November 2023 gibt es evidenzbasierte Empfehlungen zum perioperativen Management bei gastrointestinalen Tumoren (POMGAT) auf S3-Niveau. Vieles wird schon entsprechend der Empfehlungen durchgeführt. Wo es im Alltag noch hapert, zeigt eine Umfrage in einem Klinikverbund.

CUP-Syndrom: Künstliche Intelligenz kann Primärtumor finden

30.04.2024 Künstliche Intelligenz Nachrichten

Krebserkrankungen unbekannten Ursprungs (CUP) sind eine diagnostische Herausforderung. KI-Systeme können Pathologen dabei unterstützen, zytologische Bilder zu interpretieren, um den Primärtumor zu lokalisieren.

Sind Frauen die fähigeren Ärzte?

30.04.2024 Gendermedizin Nachrichten

Patienten, die von Ärztinnen behandelt werden, dürfen offenbar auf bessere Therapieergebnisse hoffen als Patienten von Ärzten. Besonders gilt das offenbar für weibliche Kranke, wie eine Studie zeigt.

Adjuvante Immuntherapie verlängert Leben bei RCC

25.04.2024 Nierenkarzinom Nachrichten

Nun gibt es auch Resultate zum Gesamtüberleben: Eine adjuvante Pembrolizumab-Therapie konnte in einer Phase-3-Studie das Leben von Menschen mit Nierenzellkarzinom deutlich verlängern. Die Sterberate war im Vergleich zu Placebo um 38% geringer.

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise