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Arthritis Research & Therapy

Erschienen in:

01.12.2007 | Review

Cells of the synovium in rheumatoid arthritis. Synovial fibroblasts

verfasst von: Ulf Müller-Ladner, Caroline Ospelt, Steffen Gay, Oliver Distler, Thomas Pap

Erschienen in: Arthritis Research & Therapy | Ausgabe 6/2007

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Abstract

For some time synovial fibroblasts have been regarded simply as innocent synovial cells, mainly responsible for synovial homeostasis. During the past decade, however, a body of evidence has accumulated illustrating that rheumatoid arthritis synovial fibroblasts (RASFs) are active drivers of joint destruction in rheumatoid arthritis. Details regarding the intracellular signalling cascades that result in long-term activation and synthesis of proinflammatory molecules and matrix-degrading enzymes by RASFs have been analyzed. Molecular, cellular and animal studies have identified various interactions with other synovial and inflammatory cells. This expanded knowledge of the distinct role played by RASFs in the pathophysiology of rheumatoid arthritis has moved these fascinating cells to the fore, and work to identify targeted therapies to inhibit their joint destructive potential is underway.

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Titel: Cells of the synovium in rheumatoid arthritis. Synovial fibroblasts
verfasst von: Ulf Müller-Ladner
Caroline Ospelt
Steffen Gay
Oliver Distler
Thomas Pap
Publikationsdatum: 01.12.2007
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe 6/2007
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar2337

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Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

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