Although uncemented cup implants frequently are used in young patients, we believe long-term survival rates of cups in these patients are somewhat disappointing, and therefore we have continued to use cemented cups in primary THA, even in young patients. However, in cases of acetabular bone stock defects, we also use bone impaction grafting. We prospectively followed 130 patients with 175 cemented cups; no patients were lost to followup. The mean age of the patients at surgery was 31 years (range, 16–39 years). An acetabular reconstruction with bone impaction grafting was performed in 84 hips (48%). The minimum followup was 2 years (average, 8.1 years; range, 2.0–18.5 years). Twenty-one of the 175 cups (12%) were revised at an average of 8.1 years (range, 2.0–18.5 years). Reasons for revision were infection (one early, seven late), recurrent dislocations (two), traumatic loosening (one), and aseptic loosening (10). The 10-year survival rate of all cemented cups with end point of revision for any cause was 85%. Survival with end point of aseptic loosening of all cups was 92%. Survival with end point of revision for aseptic loosening was 90% for the cups without impaction grafting and 95% for the cups with impaction grafting. We believe cemented acetabular cups in young patients have acceptable midterm survival; however, in the case of acetabular bone defects, we recommend reconstruction with impaction grafting.
Level of Evidence: Level III, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.
Hinweise
One or more of the authors (BWS, JWMG) have received funding from Stryker-Howmedica, Newbury, UK. All received financial support was directed solely to a research fund and no personal benefits were received.
Each author certifies that his or her institution has approved the human protocol for this investigation and that all investigations were conducted in conformity with ethical principles of research.
Introduction
Obtaining a satisfying long-term survival of THAs in patients younger than 40 years remains a challenge. Young patients must function longer with their THA than the typical patient who has a THA, and they also engage in a higher level of activity, which is associated with higher revision rates [19, 27]. Therefore, this population is more dependent on durable implants with excellent long-term survival. Although stem survival is acceptable in most studies, in general, cup survival is the weakest link in patients younger than 40 years [5, 8, 9, 15, 18, 20, 25]. The difference in reported survival rates between the cup and stem varies from 1% (97% [stem] versus 96% [cup] [18]) to 11% (98.3% [stem] versus 87.6% [cup] [20]). Despite attempts to improve cup designs and using new materials in THA, the acetabular component still shows lower survival rates than femoral implants.
One popular option is to implant uncemented acetabular cups in young patients as part of a total uncemented THA or hybrid THA (uncemented cup, cemented stem). Although cement in young patients commonly is not used [1, 24, 35], we always have implanted cemented cups in patients of all ages, but with one substantial modification: in all patients with substantial acetabular bone stock deficiencies, we have reconstructed this bone stock loss using impaction bone grafting with a cemented cup. Secondary osteoarthritis resulting from underlying diseases in these young patients often is seen with associated loss of acetabular bone stock (for example, in developmental dysplasia of the hips and juvenile rheumatoid arthritis).
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With this approach using cemented cups in young patients for many years, we asked whether there were any differences between cemented cups in young patients (younger than 40 years) with and without reconstruction with impaction grafting concerning (1) clinical scores, (2) revisions, (3) complications, (4) radiographic appearances, (5) polyethylene wear, and (6) survival.
Materials and Methods
We retrospectively reviewed prospectively collected data of all 130 patients (175 hips) who had a primary THA in our department between January 1988 and July 2004 and who were younger than 40 years at the time of index surgery. We used a cemented femoral stem and cemented acetabular polyethylene cup in all patients. In patients with acetabular bone deficiencies, these deficiencies were reconstructed with the impaction grafting technique. The decision to use bone impaction grafting was made based on the preoperative radiographs in combination with intraoperative findings. A trial cup was placed on the transverse ligament; in the case of a protrusion hip or a superolateral rim defect, a reconstruction was performed. Eighty-four hips (48%) had impaction grafting whereas 91 (52%) did not have impaction grafting. Because a cemented THA was our only treatment technique, patients with all diagnoses were included (Table 1). The majority (62%) of the patients had developmental dysplasia of the hips, rheumatoid arthritis, or corticosteroid-induced avascular necrosis. Fifty-five (42%) patients were males and 75 (58%) were females. Eighty-nine (51%) THAs were on the left side and 86 (49%) were on the right. Forty-five (35%) patients had bilateral THAs. The average age of the patients at index surgery was 31.3 years (range, 16–39 years). The mean body mass index was 25.5 (range, 17.9–36.3). According to the classification of Charnley [7], 46 hips were in Category A, 71 in B, and 58 in C. We followed all patients in this prospective cohort on a regular basis and the minimum followup was 2 years (average, 8.1 years; range, 2.0–18.5 years) after surgery. During followup, six patients (eight hips) died of causes not related to the hip or hip surgery. All patients who died were followed on a regular basis and their data included; none had revision surgery. Of the original group of 175 cups, the data of only one patient were incomplete. Based on a telephone interview, the prosthesis of this patient functioned well; however, a recent radiograph was missing.
Table 1
Indications for primary THA with and without reconstruction with bone impaction grafting
Indication
Number of hips
Without bone impaction grafting
With bone impaction grafting
Total
Developmental dysplasia of the hip
10
32
42
Rheumatoid arthritis
17
10
27
Perthes’ disease
4
4
8
Avascular necrosis of unknown cause
6
2
8
Epiphyseal dysplasia
5
2
7
Posttraumatic osteoarthritis
2
4
6
Bechterew’s disease
3
2
5
Posttraumatic avascular necrosis
4
1
5
Morquio’s disease
1
3
4
Epiphysiolysis
1
3
4
Septic coxitis
2
1
3
Protrusio acetabuli
0
3
3
Osteomyelitis
0
3
3
Spontaneous fusion of the hip of unknown cause
1
1
2
Osteogenesis imperfecta
0
2
2
Polycystic disease of unknown cause
2
0
2
Psoriatic arthritis
0
1
1
Gigantism of unknown cause
0
1
1
Pseudohypoparathyroidism
1
0
1
Monoarthritis of unknown cause
0
1
1
Alcohol-induced avascular necrosis
1
0
1
Corticosteroid-induced avascular necrosis
31
8
39
Systemic lupus erythematosus
9
Kidney transplantation/nephropathy
7
Subarachnoid hemorrhage
4
Non-Hodgkin’s lymphoma
3
Crohn’s disease
3
Cerebral aneurysm
2
Head trauma
2
Thrombocytopenia
2
Hypothalamus hormone substitution
1
Germ cell tumor
1
Aplastic anemia
1
Pituitary adenoma
1
Wegener’s disease
1
Acute lymphatic leukemia
1
Meduloblastoma
1
Total
91
84
175
We categorized acetabular defects in accordance with the classification system of the American Academy of Orthopaedic Surgeons [10]. Eighty-six hips (49%) had an acetabular deficiency. Type I segmental deficiencies occurred in 16 hips, Type II cavitary defects in 39 hips, and Type III combined deficiencies in 29 hips. One patient (two hips) had ankylosis of the hips, a Type V deficiency. Using impaction grafting, we reconstructed all deficiencies, including mild cavitary defects; however most were larger defects.
Differences between the two groups (with and without impaction grafting) were analyzed regarding diagnosis and gender (chi square test, both p = 0.001). In the group with an acetabular reconstruction, a larger proportion was female and was diagnosed with developmental dysplasia of the hips compared with the group without reconstruction. There were no differences regarding age at surgery, side, bilateral THAs, followup, type of cup used, cup inner diameter, and body mass index between the two groups.
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Two-thirds of the operations (67%) were performed by or under the supervision of two senior faculty orthopaedic surgeons (BWS, JWMG). A posterolateral approach without trochanteric osteotomy was used in all hips, with the exception of two. Intraoperatively, in one patient, a preplanned Sugioka procedure was converted to a THA; however, a trochanteric osteotomy already had been performed. In the other patient, a trochanteric osteotomy was performed in a technically demanding hip with a short femoral neck. In one patient, an additional anterior approach was needed because of ankylosis of the hip. All acetabular deficiencies were reconstructed (with the exception of one case) with impaction grafting using autografts and/or allografts in 84 hips (48%); this technique has been described in detail [28‐30]. Segmental bone defects first were reconstructed with wire meshes before the morselized bone graft was impacted and a conventional full polyethylene cup was cemented. In one patient, we reconstructed a lateral rim deficiency without impaction grafting using a solid autograft fixed with two screws. In one of the ankylosed hips (Type V deficiency), we did not use impaction grafting. We used allografts only with impaction grafting in four hips (4.8%), autografts only in 72 hips (85.7%), and combined allografts and autografts in eight hips (9.5%). Allografts were used when the original femoral head was not large enough to reconstruct the defect or in cases with pathologic femoral heads (for example, avascular necrosis of the femoral head). In three cases, instead of a solitary metal mesh, a solid fragment was used in combination with impaction grafting. In two of these cases, a minor segmental defect in the medial wall was closed using a cortical-trabecular fragment of a femoral head. A wire mesh was placed medial on top of the fragment and the acetabulum was reconstructed with impaction grafting. In the third case, a cortical head fragment was used to support the anterior rim together with a rim mesh in a reconstruction. The number of femoral heads used as grafts varied from one to four. In 40 hips (48%), metal wire mesh was used for acetabular reconstruction with impaction grafting (10 medial wall meshes, 39 rim meshes). In nine early cases, we placed a mesh on top of the bone graft just before cementation, but this mesh was not part of a segmental defect reconstruction. However, after we realized this mesh did not add any stability to the reconstruction and there were no signs of damaging of the graft or graft healing by direct contact with cement, we abandoned the use of a mesh for this purpose.
We used 79 (45%) Exeter™ Contemporary™ cups with an inner diameter of 28 mm (n = 75) and 22.225 mm (n = 5) (Stryker Howmedica, Newbury, UK), 71 (41%) Charnley® Elite™ cups with an inner diameter of 22.225 mm (n = 6) or 28 mm (n = 65) (DePuy, Leeds, UK), and 25 (14%) Müller/AlloPro cups with an inner diameter of 32 mm (n = 19), 28 mm (n = 2), or 22.225 mm (n = 4) (Sulzer, Winterthur, Switzerland). For the femoral component, we used an Exeter™ stem in 111 cases, a Charnley® Elite™ stem in 48 cases, and a Müller stem in 16 cases. All femoral heads used were made of a cobalt-chrome alloy; no ceramic implants were used.
We cemented acetabular components with a third-generation cementing technique. In the directly cemented cups, after reaming, multiple small drill holes were made with a 2.6-mm drill. After using pulse lavage, vacuum-mixed cement was injected directly from the cement gun and the cement was pressurized by a seal. In cases of reconstruction with bone grafts, we reamed the acetabulum, made multiple drill holes in sclerotic areas, and irrigated the acetabulum. Next the bone graft was impacted. Again, vacuum-mixed cement was injected and pressurized and the cup was inserted. Before 1989, we used Palacos® bone cement (Merck, Darmstadt, Germany); however, since 1989, we have used Surgical Simplex® (Stryker Howmedica). In 165 cases (94%), cement loaded with antibiotics was used. All patients received antibiotic prophylaxis consisting of 2 g cefazolin intravenously just before surgery. Other precautionary measures to prevent infections were use of an operating theater with laminar airflow and use of two pairs of sterile gloves.
Postoperatively, all patients received thrombosis prophylaxis with low-molecular-weight heparin for 6 weeks, or before 1999, with acenocoumarol (the individual dosage regimens regulated with regular coagulation tests) for 3 months. To prevent heterotopic ossification, we used nonsteroidal antiinflammatory drugs (NSAIDs) for 7 days. In six patients in whom NSAIDs were contraindicated, we administered one dose (7 Gy) of radiotherapy 1 day postoperatively.
Patients without acetabular reconstruction were mobilized under supervision of a physiotherapist after 1 or 2 days. Full weightbearing was increased in 2 to 6 weeks with the aid of one or two crutches. The patients who underwent impaction grafting were mobilized according to a modified protocol; in the first 6 weeks, only 10% weightbearing was allowed and then 6 to 12 weeks of 50% weightbearing using two crutches was allowed. After 12 weeks, full weightbearing mobilization was allowed. Thirty-one hips had such an extensive reconstruction of major defects that several weeks of bed rest were maintained ranging from 1 to 6 weeks. We used this modified mobilization protocol to ensure graft incorporation before full weightbearing.
Routine followups were scheduled at 6 weeks; 3, 6, and 12 months; and yearly or biannually thereafter. At our outpatient clinic, student researchers not participating in the treatment performed clinical analysis using the Harris hip score [17], the Oxford Hip Questionnaire Score (since 1998) [11], and visual analog scales for pain during rest and physical activity on a scale from 0 (no pain) to 100 (unbearable pain). We report the clinical scores of all patients excluding the 21 patients whose hips were revised during followup.
All anteroposterior pelvis and lateral radiographs of all hips were analyzed on a consensus basis by two of the authors (DCJDK, BWS). Radiographic evaluation included assessment of cup position, loosening of the acetabular component, polyethylene wear, presence of osteolysis, structural quality of the bone graft, application and position of the meshes, migration, heterotopic ossification, and fracture of the cement, mesh, or prosthesis. Radiolucent lines and osteolysis were recorded according to the three acetabular zones as described by DeLee and Charnley [12]. Radiographic loosening was defined as 2 mm or greater demarcation in two or three zones around the acetabular component, progressive demarcation, 3 mm or greater component migration, 5° or greater component tilting, and/or cement or prosthesis fracture. We determined cup migration (> 3-mm shift in any direction or > 5° tilting) in relation to the interteardrop line instead of the Kohler line [16]. Position of the cup of 45° ± 10° was considered normal [26]. We calculated polyethylene wear using the method of Dorr and Wan [13]. All measurements were corrected for magnification. Heterotopic ossification was classified according to the system of Brooker et al. [6]. Graft incorporation was defined as the presence of the crossing of trabecular bone on the bone-graft interface on the radiographs. Clinical failure was defined as the need for revision of the acetabular component for any reason.
We calculated Kaplan-Meier curves to study the survival (time to revision). The end points were (1) cup revision for any reason, (2) cup revision for any reason excluding infections, (3) cup revision for aseptic loosening, and (4) radiographic signs of cup loosening. With an average followup of 8.1 years, 30% of all patients had a followup longer than 10 years. The log-rank test was used to test the differences in survival between cups with and without impaction grafting. Differences in outcomes between the groups were determined with the Student’s t-test (continuous variables after checking for normal distribution) or chi square test (nominal variables).
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Results
The outcome of the Harris hip score and the Oxford Hip Questionnaire Score improved (p < 0.0001) after surgery for both groups; there were no differences in preoperative and postoperative clinical outcomes between the cups with and without acetabular reconstruction (Table 2). The postoperative experienced pain score was low.
Table 2
Outcome of clinical questionnaires
Questionnaire
Preoperative score
Postoperative score
With bone impaction grafting
Without bone impaction grafting
Independent t test p value
With bone impaction grafting
Without bone impaction grafting
Independent t test p value
Harris hip score
48 (15–81) (n = 46)
50 (28–82) (n = 50)
0.672
92 (35–100) (n = 72)
96 (12–100) (n = 73)
0.546
Oxford Hip Questionnaire Score
39 (30–52) (n = 9)
38 (12–52) (n = 15)
0.100
17 (12–45) (n = 70)
15 (12–41) (n = 72)
0.151
VAS pain at rest
NA
NA
0 (0–75) (n = 70)
0 (0–70) (n = 71)
0.260
VAS pain during physical activity
NA
NA
10 (0–90) (n = 70)
0 (0–100) (n = 71)
0.267
Values are expressed as median, with range in parentheses; VAS = visual analog scale; NA = not available.
The number of revisions in the groups with and without bone grafts was not different (p = 0.152). At last followup, 21 of the 175 cups (12%) had been revised, seven of which had reconstruction with impaction grafting (Table 3). Reasons for revision were infection (eight), recurrent dislocations (two), traumatic loosening (one), and aseptic loosening (10). Revision for aseptic loosening was performed in 10 acetabular implants (5.7%). The cup only was revised in eight cases and the cup and stem were revised in two cases. Four of the 10 revised cups had reconstruction with impaction grafting and six cups were implanted with standard techniques without any graft. The failed cups reconstructed with impaction grafting were revised after 4.1, 9.8, 16.2, and 16.8 years (average, 11.7 years). The six directly cemented cups were revised after an average of 4.0 years (range, 1.1–10.0 years). The time to revision for aseptic loosening was longer (p = 0.032) for the reconstructed cups with impaction grafting than for the cups implanted with standard techniques. The eight infected hips (4.6%) all had revision because of culture-proven infection of the implant. The average time to revision for septic loosening was 5.3 years (range, 2.2–8.1 years). Staphylococcus epidermidis was isolated in three, Staphylococcus aureus in two, Proprioni in two, Pseudomonas aeruginosa in one, and Streptococcus oralis in one. As a result of recurrent dislocations, two cups (1.1%) were revised at 3.5 and 8.6 years after the index operation. One implant (0.6%) was radiographically and clinically loose after trauma and needed revision of both components.
Table 3
Overview of the revised cups (n = 21)
Patient
Years to revision
Cause
Part revised
Bone impaction grafting
Indication
Years to radiographic loosening
Previous hip operations
5
7.3
Infection
THA
No
Corticosteroids (systemic lupus erythematosus)
No
20
6.1
Infection
THA
Yes
Avascular necrosis of unknown cause
Yes
50
5.7
Infection
THA
No
Corticosteroids (Crohn’s Disease)
2.6
Yes
68
8.1
Infection
THA
No
Rheumatoid arthritis
No
87
5.3
Infection
THA
No
Developmental dysplasia of the hip
5.2
Yes
104
4
Infection
THA
No
Corticosteroids (subarachnoid bleeding)
No
113
3.4
Infection
THA
Yes
Corticosteroids (pituitary adenoma)
Yes
123
2.2
Infection
THA
No
Medial column fracture
0.5
Yes
111
8.6
Recurrent dislocations
Cup
No
Posttraumatic coxarthrosis
No
160
3.5
Recurrent dislocations
Cup
Yes
Corticosteroids (cerebral aneurysm)
Yes
84
10.3
Traumatic loosening
THA
No
Corticosteroids (head trauma)
9.9
No
29
4.1
Aseptic loosening
Cup
Yes
Rheumatoid arthritis
4
No
41
2.3
Aseptic loosening
Cup
No
Corticosteroids (systemic lupus erythematosus)
2.2
Yes
45
3.1
Aseptic loosening
Cup
No
Spontaneous fusion of unknown cause
0.3
No
49
1.1
Aseptic loosening
Cup
No
Corticosteroids (kidney transplantation)
4.2
No
77
16.8
Aseptic loosening
Cup
Yes
Posttraumatic coxarthrosis
16.6
Yes
78
9.8
Aseptic loosening
Cup
Yes
Coxarthritis
9.8
Yes
79
16.2
Aseptic loosening
THA
Yes
Developmental dysplasia of the hip
16.2
No
82
10
Aseptic loosening
Cup
No
Developmental dysplasia of the hip
5.2
No
90
6.4
Aseptic loosening
THA
No
Developmental dysplasia of the hip
No
153
1.1
Aseptic loosening
Cup
No
Epiphysiolysis
Yes
We observed similar (p = 0.959) numbers of overall complications in the groups with and without bone grafts. However, dislocations were more common (p = 0.045) in the group without bone grafts than in the group with bone grafts (15 versus 5, respectively). Patients without reconstruction with impaction grafting had an increased dislocation chance of 1:2.9. During followup, there were nine intraoperative complications and 30 postoperative complications (Table 4). One additional stem was revised because of aseptic loosening and two femoral heads were exchanged because of recurrent dislocations. Seven hips underwent additional surgery because of postoperative complications (Table 4).
Table 4
Overview of complications
Type of complication
Number
Intraoperative complications (n = 9)
Entrapment of sciatic nerve during reposition, permanent damage
1
False route femur
1
Incomplete femoral fracture
2
Malposition cup
1
Malposition stem
1
Instrument failure
1
Suspicion of breakthrough of sterility
2
Postoperative complications (n = 30)
Superficial wound infection
3
Single dislocation
9
Recurrent dislocations
6
Sensory nerve palsy
4
Sensory and motor nerve palsy
1
Hematoma
6
Bleeding after 4 months
1
Heterotopic ossifications (n = 44)
Brooker Class I
15
Brooker Class II
19
Brooker Class III
10
Postoperative complications leading to revision (no cup revision) (n = 3)
Stem revision for aseptic loosening
1
Head exchange because of recurrent dislocations
2
Postoperative complications requiring surgical intervention (no revision) (n = 7)
Deep wound infection
4
Heterotopic ossifications
1
Traumatic dislocation
1
Persistent motor and sensory nerve palsy
1
There were no differences between the cups with and without acetabular reconstruction concerning the occurrence of cup migration, radiographic loosening, or the presence of osteolysis, cysts, and abnormal cup position (Table 5). Cups with impaction grafting had fewer radiolucent lines (p = 0.02) and fewer lines in Zone I (p = 0.001) (Table 5). All lines, except two, were on the bone-cement interface. In 28 (48%) of the 58 cups with radiolucent lines, the lines were progressive. Of the 175 hips, 160 were radiographically stable (Fig. 1). Fifteen cups were difficult to evaluate because of overlap of the metal mesh (11 Zone I; four Zones I + II). We observed graft osteolysis in only one patient with impaction grafting; all other grafts were fully incorporated. The hip revised because of traumatic loosening had a fracture in Zone II of the acetabulum; no other fractures were seen. Fifteen (8.6%) cups were radiographically loose, three had cup migration (after 1.8, 9.8, and 11.2 years postoperatively), and 12 had evident radiolucent lines in all zones and/or severe osteolysis; 12 of these cups were revised (Table 3).
Table 5
Radiographic findings of all cups*
Radiographic finding
All
With bone impaction grafting
Without bone impaction grafting
p Value (where appropriate)
Radiographic loosening
15
5
10
0.608
Cup migration
3
1
2
0.234
Radiolucent lines
58
18
40
0.02
Zone I
18
3
15
0.001
Zone II
2
0
2
Zone III
17
9
8
Zones I + II
4
2
2
Zones II + III
5
2
3
Zones I + III
5
1
4
Zones I + II + III
7
1
6
Osteolysis
11
5
6
0.861
Zone I
7
2
5
Zone II
1
1
0
Zone III
3
2
0
Cysts
1
0
0
0.033
Zone I
1
0
0
Zone II
0
0
0
Zone III
0
0
0
Cup position
Neutral position (35°–55°)
160
77
83
Abnormal position
15
7
8
0.914
Vertical (> 55°)
12
6
6
Horizontal (< 35°)
3
1
2
Polyethylene wear
Mean nonrevised cups (mm/year)
0.080
0.076
0.084
0.539
Mean revised cups (mm/year)
0.214
0.182
0.230
0.525
* Total cups (n = 175); Cups with (n = 84) or without (n = 91) reconstruction with bone impaction grafting.
Fig. 1A–C
The radiographs illustrate reconstruction of the acetabuli in a 34-year-old woman with bilateral DDH (Crowe Grade 3). (A) A preoperative anteroposterior radiograph shows the acetabuli. (B) An anteroposterior radiograph taken immediately postoperatively shows the THAs with the acetabuli reconstructed with impaction grafting. (C) An anteroposterior radiograph taken 12 years postoperatively shows the THAs remain radiographically stable, but Brooker Classes III (left) and I (right) heterotopic ossifications are visible.
×
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There was no difference in polyethylene wear rates between the cups with and without impaction grafting (p = 0.539 in 154 unrevised cups and p = 0.525 in the 21 revised cups) (Table 5). When looking at all cups (with and without acetabular reconstruction), the revised and radiographically loose cups had more wear compared with the cups that were not revised (both p < 0.0001). Patients with an abnormal position of the cup had similar (p = 0.196) polyethylene wear rates to those who had a normal position. Analysis of polyethylene wear rates of cups with different inner diameters showed no differences (independent t test, 22 versus 28 mm: p = 0.135, 22 versus 32 mm: p = 0.484, 28 versus 32 mm: p = 0.620).
There were no differences in survival after 10 years between the groups with and without bone impaction grafting (Table 6). The midterm survival rates of all cemented polyethylene cups varied from 85% to 92% at 10 years with four end points (Table 6; Figs. 2, 3). Cup survival with an end point of radiographic loosening was 89% (95% confidence interval, 83%–95%).
Table 6
The 10-year survival rates*
End point
All cups
Without bone impaction grafting
With bone impaction grafting
Log-rank p value
Revision for any reason
85% (78%–92%)
79% (68%–90%)
91% (82%–99%)
0.21
Revision for any reason excluding infections
91% (85%–97%)
87% (78%–99%)
94% (87%–100%)
0.56
Revision for aseptic loosening
92% (87%–98%)
90% (81%–99%)
95% (89%–100%)
0.73
* Kaplan-Meier estimates; 95% confidence interval in parentheses.
Fig. 2A–B
Kaplan-Meier survival curves with 95% confidence intervals (broken lines) of all cups with end points of (A) revision for any reason and (B) revision for aseptic loosening are shown. The vertical bars indicate the censored data points.
Fig. 3A–B
Kaplan-Meier survival curves of cups without impaction grafting (thick broken line, 95% confidence intervals in thin broken lines) and cups with impaction grafting (thick solid line, 95% confidence intervals in thin solid lines) with end points of (A) revision for any reason and (B) revision for aseptic loosening are shown.
×
×
Discussion
The use of cemented THA in young patients is not very popular and most surgeons will use uncemented or will resurface hips in these patients. However, we have continued to use only cemented implants in THA even in young patients. In our view, the real challenge in THA in these young patients is to manage the commonly seen acetabular deficiencies. In cases of acetabular defects, we reconstruct these deficiencies with impaction bone grafting. We questioned whether there was a difference in clinical outcome, revisions, complications, radiographic appearances, polyethylene wear, and survival between the cups implanted with an acetabular reconstruction with impaction grafting and those implanted with standard cementing techniques.
Our study has several limitations: short followup, lack of assessment of activity levels, clinical interobserver variability, heterogeneous group, no comparison with other reconstruction techniques, and different types of implants used. With no patients lost to followup, our followup is representative and reliable for the midterm results [22], and long-term followup (> 15 years) was not available at the time of this review. Our results can be biased by an important factor we did not evaluate: the level of activity. Theoretically, with restoration of the affected hip(s) into well-functioning artificial joints, most patients will increase their level of activity. However, young patients undergoing THA with acetabular deficiencies and therefore more complex reconstructions could still have a lower level of activity after surgery relative to primary cemented cups. However, the average wear of the cups with impaction grafting was the same as the cups without impaction grafting (both 0.08 mm/year). Provided that activity is a major cause of polyethylene wear, this might imply the level of activity is similar in these two groups. Several studies suggest the revision and polyethylene wear rates are correlated to level of activity [2, 19, 27, 31, 38]. Additional research on level of activity and impaction grafting in young patients is necessary to confirm this hypothesis. The clinical questionnaires were obtained by student researchers who did not participate in the treatment. Multiple researchers were involved in the data collection and interobserver variability has not been tested; however, all researchers were trained and supervised to obtain these questionnaires correctly.
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The clinical scores were comparable between the two groups and comparable to published scores (Table 7). Although the cups reconstructed with bone impaction grafting were the more demanding procedures, no clinical differences were seen.
Table 7
Reported outcomes of the Harris hip score in patients < 40 years for primary THA
Values are expressed as median (current study) or means (other studies), with range in parentheses.
Although revision rates in both groups were comparable, the time to revision was longer in the cups reconstructed with bone impaction grafting. We have no clear explanation for this observation; possibly the cement-bone interface was better in cups with bone impaction grafting with better interdigitation of the cement into the bone [36]. This also may explain the lower incidence of radiolucent lines in the cups reconstructed with bone impaction grafting. The number of revisions for septic loosening was relatively high during this midterm followup study (4.6%). Only one septic loosening likely was related to the surgery; we considered all other infections acute hematogenous infections of previously well-functioning prostheses. The use of corticosteroids and newer rheumatic disease-modifying drugs, which were used in most of the infection cases, can explain this higher risk of infection [3, 4]. Sochart and Porter [33] had only two infections in their study, but both were in patients with rheumatoid arthritis. Still, our revision rate for septic loosening of 4.6% is relatively high in contrast to other studies, such as that of Joshi et al. [18], with an infection rate of 1.3%. Remarkably, many septic loosenings occurred late (> 2 years postoperatively).
The cups reconstructed with impaction grafting showed fewer complications by having fewer dislocations than the cups implanted by standard techniques. This might be attributed to the different mobilization protocol for the patients who received cups with impaction grafting. Immobilization is associated with lower dislocation rates [21]. The overall dislocation rate in our study was 11.4%, which is relatively high. However, subluxation rates in young patients having THA have been reported to be as much as 18.2% [14]. The overall complication rate of 17% (30 postoperative complications) is also relatively high. Joshi et al. [18] reported a complication rate of 11.5% in cemented hips and Duffy et al. [15] reported a complication rate of 12% during the perioperative period.
As expected, revised and radiographically loose cups showed more polyethylene wear. This is consistent with previous reports showing wear particles are associated with osteolysis in THA [27, 33, 37]. The average wear rate of the cups of 0.08 mm/year is within the normal limits, keeping in mind that wear in younger patients can be 33% to 40% higher than wear in older patients [27]. In a large study of 226 hips in patients younger than 40 years with a Charnley® prosthesis, Sochart and Porter [33] reported an average wear rate of 0.08 to 0.10 mm/year in the nonrevised cups, which is comparable to our results. Wan et al. [37] found a correlation between inclination of the cup and higher/lower wear rates. However, we did not observe higher wear with abnormal position or inner cup diameter.
The observed overall midterm survival of cemented polyethylene cups in patients younger than 40 years in our study was acceptable. Especially in these young patients, there is a need for total hip implants with proven long-term survival [20]. Although the use of uncemented prostheses in these young patients is very popular, literature regarding long-term outcome of THA in patients younger than 40 years concerns mainly studies of cemented implants and less about uncemented implants (Table 8) [5, 8, 9, 15, 18, 20, 25, 32‐34]. A limitation of the reported midterm or long-term results of uncemented cups is the fact that in these studies first-generation uncemented cups were used. The long-term outcome of improved newer uncemented cup designs remains unclear. Most of these older cup designs no longer are available. The only report of uncemented cups at 15 years after surgery with an end point of revision for any reason showed a survival rate of 54% [20]. This is less favorable than the results of cemented cups at that time (Table 8). Sochart and Porter [34] had survival rates of 71% and 68% at 20 and 25 years, respectively, for cemented Charnley® cups. The survival of the acetabular uncemented cups with an end point of revision for aseptic loosening in patients younger than 40 years reported in one study was 85% [15], in contrast to a survival rate of 96% after 10 years of the Charnley® cups in the study by Joshi et al. [18]. We found a survival rate with cemented cups of 92% at 10 years with an end point of revision for aseptic loosening.
Table 8
Long-term acetabular cup survival rates in patients younger than 40 years
Studies published through 2007; *Values are expressed as mean, with range in parentheses; †values are expressed as percentage, with 95% confidence interval in parentheses; ‡deceased and revised excluded; §lost to followup, deceased excluded, only Chinese patients; AML = anatomic medullary locking; PCA = porous-coated anatomic; Excl inf = excluding infections; H-G = Harris-Galante; SE = standard error.
A remarkable finding of our study was the survival of cups with acetabular reconstructions with impaction grafting was at least comparable to the survival of standard cemented cups, especially considering the more difficult hips of our study population needed reconstruction with impaction grafting. Our data on the cemented cups with impaction grafting showed similar survival, where rather lower survival rates would be expected. The outcome of these cups reconstructed with impaction grafting even fulfilled the NICE criteria (a survival of > 90% after 10 years) [23], with a survival rate of 91% at 10 years with an end point of revision for any reason. The survival rates of the cemented cups in our study are comparable to those reported for cemented cups [8, 18, 34].
Although cemented cups are not commonly used in young patients, our data suggest cemented conventional polyethylene cups are still a good option in THA in young patients. Even reconstruction of (severe) acetabular deficiencies with impaction grafting and a cemented conventional polyethylene cup produced very acceptable survival rates, comparable to the rates of cemented cups implanted in acetabuli without deficiencies with standard cementing techniques.
Acknowledgments
We thank Jaap Brunnekreef for assistance with data management.
Open Access
This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
Open AccessThis is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License (https://creativecommons.org/licenses/by-nc/2.0), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
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