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Current Fungal Infection Reports
Erschienen in: Current Fungal Infection Reports 1/2022

30.01.2022 | Pediatric Fungal Infections (D. Corzo-Leon, Section Editor)

Central Nervous System Fungal Infections in Paediatric Patients

verfasst von: Deborah Palacios-Reyes, Ángeles Costta-Michuy, Tania M. Vargas-Vázquez, M. Vanessa Martínez-Astudillo, Rafael Oscar Santamaría Vásquez, Nancy E. Aguilar-Gómez, Astrid A. Hernandez-Soto, Sofia Fortes-Gutiérrez, Daniel Reyes-Gutierrez, Dania J. Juárez-Padilla, Silvia Fuentes-Soliz

Erschienen in: Current Fungal Infection Reports | Ausgabe 1/2022

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Abstract

Purpose of Review

The objective of this paper is to review the main paediatric populations at risk for IFI-CNS and the most frequent agents involved, focusing in the clinical/radiological and diagnostic features, as well as the recommended treatment.

Recent Findings

With new and improved diagnostic techniques, reports on CNS fungal infections in paediatricpatients have increased not only in those with recently discovered congenital immune defects but in immunocompetent childrenas well. Information regarding clinical and imaging findings has expanded to shed light on previously ignored diagnoses.

Summary

Apart from well-described and devastating IFI caused by Candida spp. and Aspergillus spp., other fungal agents are gaining importance not only in immunocompromised patients, but also in children with no identified risk factors, apart from environmental exposure.
Literatur
1.
• Fisher BT, Robinson PD, Lehrnbecher T, Steinbach WJ, Zaoutis TE, Phillips B, et al. Risk factors for invasive fungal disease in pediatric cancer and hematopoietic stem cell transplantation: a systematic review. Vol. 7, Journal of the Pediatric Infectious Diseases Society. Oxford University Press; 2018. p. 191–8. Meta-analysis that demonstrate main risk factors for IFI in paediatric cancer and HSCT patients.
2.
Candoni A, Klimko N, Busca A, di Blasi R, Shadrivova O, Cesaro S, et al. Fungal infections of the central nervous system and paranasal sinuses in onco-haematologic patients. Epidemiological study reporting the diagnostic-therapeutic approach and outcome in 89 cases. Mycoses. 2019;62(3):252–60.CrossRef
3.
Pana ZD, Roilides E, Warris A, Groll AH, Zaoutis T. Epidemiology of invasive fungal disease in children. Vol. 6, Journal of the Pediatric Infectious Diseases Society. 2017. p. S3–11.
4.
Candoni A, Facchin G, Busca A, Lazzarotto D, Cattaneo C, Nadali G, et al. Central nervous system fungal infections in allogeneic stem cell transplantation. Outcome of 24 recent cases and literature review. Vol. 104, European Journal of Haematology. Blackwell Publishing Ltd; 2020. p. 148–50.
5.
• Dotis J, Iosifidis E, Roilides E. Central nervous system aspergillosis in children: a systematic review of reported cases. International Journal of Infectious Diseases. 2007;11(5):381–93. Considered a classical paper because it is the first and one of the largest systematic reviews on CNS aspergillosis, including risk groups not only immunocompromised but chronic patients, information about clinical presentation, outcome and species involved.CrossRef
6.
•• McCarthy MW, Kalasauskas D, Petraitis V, Petraitiene R, Walsh TJ. Fungal infections of the central nervous system in children. Journal of the Pediatric Infectious Diseases Society [Internet]. 2017 Sep 1 [cited 2018 Dec 11];6(3):e123–33. Extensive review of CNS fungal infections in paediatric patients including not only mould and candida infections but also endemic mycosis.
7.
Pana ZD, Seidel D, Skiada A, Groll AH, Petrikkos G, Cornely OA, et al. Invasive mucormycosis in children: an epidemiologic study in European and non-European countries based on two registries. BMC Infect Dis. 2016;16(1).
8.
Seidel D, Meißner A, Lackner M, Piepenbrock E, Salmanton-García J, Stecher M, et al. Prognostic factors in 264 adults with invasive Scedosporium spp. and Lomentospora prolificans infection reported in the literature and FungiScope®. https://​doi.​org/​10.​1080/​1040841X20181514​366 [Internet]. 2019 Jan 2 [cited 2021 Sep 25];45(1):1–21.
9.
Mohammadi R, Mohammadi A, Ashtari F, Khorvash F, Hakamifard A, Vaezi A, et al. Cerebral phaeohyphomycosis due to Rhinocladiella mackenziei in Persian Gulf region: a case and review. Mycoses. 2018;61(4):261–5.CrossRef
10.
Angurana SK, Suthar R, Mehta A, Nallasamy K, Garg R, Bal A, et al. Cerebral phaeohyphomycosis: fulminant encephalitic presentation. Indian J Pediatr. 2017;84(12):955–6.CrossRef
11.
Miossec C, Jacob S, Peipoch L, Brard M, Jolivet E, Hochedez P, et al. Cerebral phaeohyphomycosis due to Cladophialophora bantiana in a French Guianese child. Journal de Mycologie Médicale. 2020;30(1):100918.CrossRef
12.
Kao C, Goldman DL. Cryptococcal disease in HIV-Infected children. Current Infectious Disease Reports 2016 18:9 [Internet]. 2016 Jul 21 [cited 2021 Oct 7];18(9):1–10
13.
• Riddell J, Joseph Wheat L. Central nervous system infection with Histoplasma capsulatum. Journal of Fungi [Internet]. 2019 Sep 1 [cited 2021 Nov 15];5(3). Review on CNS histoplasmosis including high-risk groups, clinical presentations with imaging findings as well as diagnostic techniques and treatment.
14.
Jackson NR, Blair JE, Ampel NM. Central nervous system infections due to coccidioidomycosis. Journal of Fungi [Internet]. 2019 Sep 1 [cited 2021 Oct 6];5(3).
15.
Lehrnbecher T, Rath PM, Attarbaschi A, Cario G, Döring M, Moser O, et al. Galactomannan and PCR in the central nervous system to detect invasive mold disease - a retrospective analysis in immunocompromised children. Sci Rep. 2019;9(1).
16.
• Lauten M, Attarbaschi A, Cario G, Döring M, Moser O, Mücke U, et al. Invasive mold disease of the central nervous system in children and adolescents with cancer or undergoing hematopoietic stem cell transplantation: analysis of 29 contemporary patients. 2019 Aug 1 [cited 2021 Sep 26];66(8):e27806. Retrospective study of cases of IMD with CNS involvement, describing isolated species and diagnostic tools, as well as treatment.
17.
Cesaro S, Tridello G, Castagnola E, Calore E, Carraro F, Mariotti I, et al. Retrospective study on the incidence and outcome of proven and probable invasive fungal infections in high-risk pediatric onco-hematological patients. Eur J Haematol. 2017;99(3):240–8.CrossRef
18.
• Muggeo P, Calore E, Decembrino N, Frenos S, de Leonardis F, Colombini A, et al. Invasive mucormycosis in children with cancer: a retrospective study from the Infection Working Group of Italian Pediatric Hematology Oncology Association. Mycoses. 2019 Feb 1;62(2):165–70. Italian study with oncological patients highlighting risk factors, clinical presentation and treatment of paediatric mucormycosis.CrossRef
19.
•• Luckowitsch M, Rudolph H, Bochennek K, Porto L, Lehrnbecher T. Central nervous system mold infections in children with hematological malignancies: advances in diagnosis and treatment. Journal of Fungi. 2021 Mar 1;7(3):1–17. Extensive review on IMD in CNS, highlighting risk paediatric groups, very detailed in imaging findings as well as diagnostic techniques.CrossRef
20.
Porto L, You SJ, Attarbaschi A, Cario G, Döring M, Moser O, et al. Invasive mold infection of the central nervous system in immunocompromised children. J Fungi. 2020;6(4):1–10.CrossRef
21.
Góralska K, Blaszkowska J, Dzikowiec M. Neuroinfections caused by fungi. Vol. 46, Infection. Urban und Vogel GmbH; 2018. p. 443–59.
22.
Santiago-Tirado FH, Onken MD, Cooper JA, Klein RS, Doering TL. Trojan horse transit contributes to blood-brain barrier crossing of a eukaryotic pathogen. mBio. 2017;8(1).
23.
Fisher BT, Robinson PD, Lehrnbecher T, Steinbach WJ, Zaoutis TE, Phillips B, et al. Risk factors for invasive fungal disease in pediatric cancer and hematopoietic stem cell transplantation: a systematic review. Vol. 7, Journal of the Pediatric Infectious Diseases Society. Oxford University Press; 2018. p. 191–8.
24.
Cesaro S, Tridello G, Castagnola E, Calore E, Carraro F, Mariotti I, et al. Retrospective study on the incidence and outcome of proven and probable invasive fungal infections in high-risk pediatric onco-hematological patients. Eur J Haematol. 2017;99(3):240–8.CrossRef
25.
Saini A, Karmarkar S. Oncological critical care considerations in children. In: Pediatric Critical Care. Cham: Springer International Publishing; 2021.
26.
Shoham S, Dominguez EA. Emerging fungal infections in solid organ transplant recipients: guidelines of the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transplant. 2019;33(9).
27.
Scolarici M, Jorgenson M, Saddler C, Smith J, Miceli MH. Fungal infections in liver transplant recipients. 2021.
28.
Anesi JA, Baddley JW. Approach to the solid organ transplant patient with suspected fungal infection. Infect Dis Clin North Am. 2016;30(1).
29.
Firacative C. Invasive fungal disease in humans: are we aware of the real impact? Memórias do Instituto Oswaldo Cruz. 2020;115.
30.
Baddley JW, Forrest GN. Cryptococcosis in solid organ transplantation—guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clinical Transplantation [Internet]. 2019 Sep 1 [cited 2021 Aug 11];33(9):e13543.
31.
Antachopoulos C. Invasive fungal infections in congenital immunodeficiencies. Clin Microbiol Infect. 2010;16(9):1335–42.CrossRef
32.
• Winkelstein, Jerry A.*; Marino, Mary C.*; Johnston, Richard B. Jr.; Boyle, John; Curnutte, John; Gallin, John I.; Malech, Harry L.; Holland, Stephen M.; Ochs, Hans; Quie, Paul; Buckley, Rebecca H.; Foster, Charles B.; Chanock, Steven J.; Dickler H. Chronic granulomatous disease: report on a National Registry of 368 Patients. 2000. The first national registry of CGD patients, highlighting clinical presentations of infections including fungal CNS infections.
33.
Dockrell D, Wheeler RT, Lionakis MS, Drummond RA. Mechanistic insights into the role of C-type lectin receptor/CARD9 signaling in human antifungal immunity. Frontiers in Cellular and Infection Microbiology | https://​www.​frontiersin.​org. 2016;1:39.
34.
Rieber N, Gazendam RP, Freeman AF, Hsu AP, Collar AL, Sugui JA, et al. Extrapulmonary Aspergillus infection in patients with CARD9 deficiency. JCI Insight. 2021;1(17):1–13.
35.
Antachopoulos C. Invasive fungal infections in congenital immunodeficiencies. Clin Microbiol Infect [Internet]. 2010;16(9):1335–42.CrossRef
36.
Armstrong-James D, Meintjes G, Brown GD. A neglected epidemic: fungal infections in HIV/AIDS. Vol. 22, Trends in Microbiology. 2014. p. 120–7.
37.
Nyazika T, Masanganise F, Hagen F, Bwakura-Dangarembizi M, Ticklay I, Robertson VJ. Cryptococcal meningitis presenting as a complication in HIV- infected children: a case series from sub-Saharan Africa Tinashe. Pediatr Infect Dis J. 2016;176(1):139–48.
38.
Shetty D, Giri N, Gonzalez CE, Pizzo PA, Walsh TJ. Invasive aspergillosis in human immunodeficiency virus-infected children. The Pediatric infectious disease journal [Internet]. 1997 Feb [cited 2021 Nov 15];16(2):216–21.
39.
Groll AH, Castagnola E, Cesaro S, Dalle JH, Engelhard D, Hope W, et al. Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or allogeneic haemopoietic stem-cell transplantation. Vol. 15, The Lancet Oncology. Lancet Publishing Group; 2014.
40.
Caceres A, Avila ML, Herrera ML. Fungal infections in pediatric neurosurgery. Child’s Nerv Syst. 2018;34(10):1973–88.CrossRef
41.
Lopez AA, Kazina C, Del Bigio MR, Fanella S. Candida albicans ventriculoperitoneal shunt infection in an infant: a case report and review of the literature. J Assoc Med Microbiol Infect Dis Canada. 2020;5(1):35–8.
42.
Bhatti AU, Parekh MA, Amanullah M, Daeubler B. Candida albicans ventriculoperitoneal shunt infections: immunocompetent preterm pediatric case series and an extensive review of literature. Pediatr Dimens. 2017;2(1):1–4.CrossRef
43.
Dadwal SS. Epidemiology of central nervous system fungal infections. In: Fungal infections of the central nervous system. Cham: Springer International Publishing; 2019.
44.
• Chen M, Chen C, Yang Q, Zhan R. Candida meningitis in neurosurgical patients: a single-institute study of nine cases over 7 years. Epidemiology & Infection [Internet]. 2020 [cited 2021 Oct 11];148. Study analysing candida meningitis cases in neurosurgical patients including paediatric patients.
45.
Ashraf N, Kubat RC, Poplin V, Adenis AA, Denning DW, Wright L, et al. Re-drawing the maps for endemic mycoses. Mycopathologia 2020 185:5 [Internet]. 2020 Feb 10 [cited 2021 Sep 23];185(5):843–65.
46.
• Walsh TJ, Katragkou A, Chen TK, Salvatore CM, Roilides E. Invasive candidiasis in infants and children: recent advances in epidemiology, diagnosis, and treatment. Journal of Fungi [Internet]. 2019 Jan 24 [cited 2021 Oct 6];5(1). Review on invasive candidiasis, including CNS presentation, as well as diagnostic techniques and management.
47.
Bilgin E, Ökten Aİ, Gezercan Y, Çavuş G, Açık V, Arslan A, et al. Pediatric giant cerebral candida abscess: a case report. Pediatric Neurosurgery [Internet]. 2019 Jul 1 [cited 2021 Sep 19];54(3):207–11.
48.
McCarty TP, White CM, Pappas PG. Candidemia and invasive candidiasis. Infect Dis Clin North Am. 2021;35(2):389–413.CrossRef
49.
Chaussade H, Cazals X, Desoubeaux G, Jouvion G, Bougnoux ME, Lefort A, et al. Central nervous system candidiasis beyond neonates: lessons from a nationwide study. Medical Mycology [Internet]. 2021 Mar 4 [cited 2021 Nov 15];59(3):266–77.
50.
Bilgin E, Ökten Aİ, Gezercan Y, Çavuş G, Açık V, Arslan A, et al. Pediatric giant cerebral candida abscess: a case report. Pediatric Neurosurgery [Internet]. 2019 Jul 1 [cited 2021 Oct 6];54(3):207–11.
51.
• Miceli MH. Central nervous system infections due to Aspergillus and other hyaline molds. Journal of Fungi 2019, Vol 5, Page 79 [Internet]. 2019 Aug 30 [cited 2021 Sep 26];5(3):79. Review of mould infection in CNS, including aspergillosis but also Fusarium, Scedosporium and Lomentospora. Not specific for children but with description of clinical presentations as well as diagnostic tests and recommended treatment.
52.
•• Cornely OA, Alastruey-Izquierdo A, Arenz D, Chen SCA, Dannaoui E, Hochhegger B, et al. Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium. Vol. 19, The Lancet Infectious Diseases. Lancet Publishing Group; 2019. p. e405–21. Recommendations on diagnosis and treatment of mucormycosis including CNS involvement as well as paediatric patients.
53.
•• Hoenigl M, Salmanton-García J, Walsh TJ, Nucci M, Neoh CF, Jenks JD, et al. Global guideline for the diagnosis and management of rare mould infections: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology and the American Society for Microbiology. The Lancet Infectious Diseases [Internet]. 2021 Aug 1 [cited 2021 Sep 25];21(8):e246–57. Recommendations on diagnosis and treatment of non-Aspergillus mould infections including fusariosis, scedosporiosis and lomentosporiosis.
54.
Chowdhary A, Meis JF, Guarro J, de Hoog GS, Kathuria S, Arendrup MC, et al. ESCMID and ECMM joint clinical guidelines for the diagnosis and management of systemic phaeohyphomycosis: diseases caused by black fungi. Clin Microbiol Infect. 2014;20(S3):47–75.CrossRef
55.
Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, Hamill RJ, et al. Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of America. Clin Infect Dis. 2010;50(3):291–322.CrossRef
56.
Guidelines on the diagnosis, prevention and management of cryptococcal disease in HIV-infected adults, adolescents and children: supplement to the 2016 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. Geneva: World Health Organization; 2018. Licence: CC BY-NC-SA 3.0 IGO.
57.
•• Thompson GR, Le T, Chindamporn A, Kauffman CA, Alastruey-Izquierdo A, Ampel NM, et al. Global guideline for the diagnosis and management of the endemic mycoses: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology. The Lancet Infectious Diseases [Internet]. 2021 Aug [cited 2021 Oct 7];0(0). Recommendations on diagnosis and treatment on endemic mycosis including CNS involvement.
58.
• Wattier RL, Ramirez-Avila L. Pediatric invasive aspergillosis. Journal of Fungi. 2016;2(2):8–11. Review on invasive aspergillosis in paediatric patients states high risk groups as well as clinical presentation including CNS, diagnostic tests and treatment in paediatric patients.CrossRef
59.
Shariati A, Didehdar M, Rajaeih S, Moradabadi A, Ghorbani M, Falahati V, et al. Aspergillosis of central nervous system in patients with leukemia and stem cell transplantation: a systematic review of case reports. Ann Clin Microbiol Antimicrob. 2021;20(1):1–19.CrossRef
60.
Warris A, Lehrnbecher T, Roilides E, Castagnola E, Brüggemann RJM, Groll AH. ESCMID-ECMM guideline: diagnosis and management of invasive aspergillosis in neonates and children. Clinical Microbiology and Infection [Internet]. 2019 Sep 1 [cited 2021 Nov 15];25(9):1096–113.
61.
Schwartz S, Cornely OA, Hamed K, Marty FM, Maertens J, Rahav G, et al. Isavuconazole for the treatment of patients with invasive fungal diseases involving the central nervous system. Medical Mycology [Internet]. 2020 [cited 2021 Nov 15];58(4):417.
62.
de Leonardis F, Novielli C, Giannico B, Mariggiò MA, Castagnola E, Santoro N. Isavuconazole treatment of cerebral and pulmonary aspergillosis in a pediatric patient with acute lymphoblastic leukemia: case report and review of literature. Journal of Pediatric Hematology/Oncology [Internet]. 2020 Aug 1 [cited 2021 Nov 15];42(6):E469–71.
63.
Abdollahi A, shokohi T, Amirrajab N, Poormosa R, Kasiri A, Motahari SJ, et al. Clinical features, diagnosis, and outcomes of rhino-orbito-cerebral mucormycosis: a retrospective analysis. Current Medical Mycology [Internet]. 2016 Dec 1;2(4):15–23.
64.
Steinbrink JM, Miceli MH. Mucormycosis. Vol. 35, Infectious disease clinics of North America. W.B. Saunders; 2021. p. 435–52.
65.
Góralska K, Blaszkowska J, Dzikowiec M. Neuroinfections caused by fungi [Internet]. 2018 p. 443–59.
66.
Bozorgi V, Talebitaher M, Shalbaf N, Radmanesh N, Nasri F, Ansari-Ramandi MM. Epidemiological aspects and clinical outcome of patients with rhinocerebral zygomycosis: a survey in a referral hospital in Iran. Pan Afr Med J. 2016;13:24.
67.
• Bonifaz A, Tirado-Sánchez A, Calderón L, Romero-Cabello R, Kassack J, Ponce RM, et al. Mucormycosis in children: a study of 22 cases in a Mexican hospital. Mycoses. 2014 Dec 1;57(s3):79–84. One of the few Mexican studies of paediatric cases with mucormycosis, describing clinical presentation and etiologic agents.CrossRef
68.
Kerezoudis P, Watts CR, Bydon M, Dababneh AS, Deyo CN, Frye JM, et al. Diagnosis and treatment of isolated cerebral mucormycosis: patient-level data meta-analysis and Mayo Clinic experience. Vol. 123, World Neurosurgery. Elsevier Inc.; 2019. p. 425–434.e5.
69.
Kerezoudis P, Watts CR, Bydon M, Dababneh AS, Deyo CN, Frye JM, et al. Diagnosis and treatment of isolated cerebral mucormycosis: patient-level data meta-analysis and Mayo Clinic experience. Vol. 123, World Neurosurgery. Elsevier Inc.; 2019. p. 425–434.e5.
70.
Katragkou A, Fisher BT, Groll AH, Roilides E, Walsh TJ. Diagnostic imaging and invasive fungal diseases in children. Vol. 6, Journal of the Pediatric Infectious Diseases Society. 2017. p. S22–31.
71.
Kung VL, Chernock RD, Burnham CAD. Diagnostic accuracy of fungal identification in histopathology and cytopathology specimens. Eur J Clin Microbiol Infect Dis. 2018;37(1):157–65.CrossRef
72.
Schwartz S, Kontoyiannis DP, Harrison T, Ruhnke M. Advances in the diagnosis and treatment of fungal infections of the CNS. Vol. 17, The Lancet Neurology. Lancet Publishing Group; 2018. p. 362–72.
73.
• Decembrino N, Perruccio K, Zecca M, Colombini A, Calore E, Muggeo P, et al. A case series and literature review of isavuconazole use in pediatric patients with hemato-oncologic diseases and hematopoietic stem cell transplantation. Antimicrobial Agents and Chemotherapy. 2020;64(3). Paediatric cases using isavuconazole with safety and good outcomes.
74.
Dignani MC, Anaissie E. Human fusariosis. Clin Microbiol Infect. 2004;10(SUPPL. 1):67–75.CrossRef
75.
76.
van Diepeningen AD, Brankovics B, Iltes J, van der Lee TAJ, Waalwijk C. Diagnosis of Fusarium infections: approaches to identification by the clinical mycology laboratory. Current Fungal Infection Reports 2015 9:3 [Internet]. 2015 Jul 1 [cited 2021 Sep 26];9(3):135–43.
77.
Bronnimann D, Garcia-Hermoso D, Dromer F, Lanternier F, Group TFMS, Maulin L, et al. Scedosporiosis/lomentosporiosis observational study (SOS): clinical significance of Scedosporium species identification. Medical Mycology [Internet]. 2021 May 4 [cited 2021 Sep 25];59(5):486–97.
78.
Revankar SG, Sutton DA, Rinaldi MG. Primary central nervous system phaeohyphomycosis: a review of 101 cases. Clin Infect Dis. 2004;38(2):206–16.CrossRef
79.
• Huang C, Zhang Y, Song Y, Wan Z, Wang X, Li R. Phaeohyphomycosis caused by Phialophora americana with CARD9 mutation and 20-year literature review in China. Mycoses. 2019 Oct 1;62(10):908–19. Relevant case of phaeohyphomycosis in CARD9 immunodeficiency.CrossRef
80.
Nieto-Ríos JF, Villafañe-Bermúdez DR, Guerrero-Tinoco GA, Ramírez-Sánchez IC, Serna-Higuita LM, Aristizábal-Alzate A, et al. Absceso cerebral por Cladophialophora bantiana en un paciente con trasplante renal: reporte de un caso. Biomédica. 2019;39(Supl. 2):20–5.CrossRef
81.
Corvilain E, Casanova JL, Puel A. Inherited CARD9 deficiency: invasive disease caused by ascomycete fungi in previously healthy children and adults. J Clin Immunol. 2018;38(6):656–93.CrossRef
82.
Perez L, Messina F, Negroni R, Arechavala A, Bustamante J, Oleastro M, et al. Inherited CARD9 deficiency in a patient with both Exophiala spinifera and Aspergillus nomius severe infections. J Clin Immunol. 2020;40(2):359–66.CrossRef
83.
Lai SHY, Duque JSR, Chung BH-Y, Chung TW-H, Leung D, Ho RS-L, et al. Invasive cerebral phaeohyphomycosis in a Chinese boy with CARD9 deficiency and showing unique radiological features, managed with surgical excision and antifungal treatment. Int J Infect Dis. 2021;107:59–61.CrossRef
84.
Kantarcioglu AS, Guarro J, de Hoog GS, Apaydin H, Kiraz N, Balkan II, et al. A case of central nervous system infection due to Cladophialophora bantiana. Rev Iberoam Micol. 2016;33(4):237–41.CrossRef
85.
Kuan CS, Cham CY, Singh G, Yew SM, Tan YC, Chong PS, et al. Genomic analyses of Cladophialophora bantiana, a major cause of cerebral phaeohyphomycosis provides insight into its lifestyle, virulence and adaption in host. PLoS ONE. 2016;11(8).
86.
Angurana SK, Suthar R, Mehta A, Nallasamy K, Garg R, Bal A, et al. Cerebral phaeohyphomycosis: fulminant encephalitic presentation. The Indian Journal of Pediatrics 2017 84:12 [Internet]. 2017 May 2 [cited 2021 Aug 1];84(12):955–6.
87.
Revankar SG, Sutton DA, Rinaldi MG. Primary central nervous system phaeohyphomycosis: a review of 101 cases. Clinical Infectious Diseases [Internet]. 2004 Jan 15 [cited 2021 Sep 8];38(2):206–16.
88.
Kantarcioglu AS, Guarro J, de Hoog S, Apaydin H, Kiraz N. An updated comprehensive systematic review of Cladophialophora bantiana and analysis of epidemiology, clinical characteristics, and outcome of cerebral cases. Medical Mycology [Internet]. 2017 Aug 1 [cited 2021 Aug 1];55(6):579–604.
89.
Chander J, Singla N, Kundu R, Handa U, Chowdhary A. Phaeohyphomycosis caused by Rhytidhysteron rufulum and review of literature. Mycopathologia 2016 182:3 [Internet]. 2016 Sep 15 [cited 2021 Aug 1];182(3):403–7.
90.
Kundu R, Handa U, Punia RS, Singla N, Chander J, Attri AK. Phaeohyphomycosis: cytomorphologic evaluation in eleven cases. Acta Cytologica [Internet]. 2020 Sep 1 [cited 2021 Aug 1];64(5):406–12.
91.
Lahiri Mukhopadhyay S, Mahadevan A, Bahubali VH, Dawn Bharath R, Prabhuraj AR, Maji S, et al. A rare case of multiple brain abscess and probably disseminated phaeohyphomycosis due to Cladophialophora bantiana in an immunosuppressed individual from India. Journal de Mycologie Médicale. 2017;27(3):391–5.CrossRef
92.
Barde F, Billaud E, Goldwirt L, Horodyckid C, Jullien V, Lanternier F, et al. Low central nervous system posaconazole concentrations during cerebral phaeohyphomycosis. Antimicrobial Agents and Chemotherapy [Internet]. 2019 [cited 2021 Nov 15];63(11).
93.
Dobias R, Filip M, Vragova K, Dolinska D, Zavodna P, Dujka A, et al. Successful surgical excision of cerebral abscess caused by Fonsecaea monophora in an immunocompetent patient and review of literature. Folia Microbiologica 2018 64:3. 2018 Oct 27;64(3):383–8.
94.
• Gushiken AC, Saharia KK, Baddley JW. Cryptococcosis. Infectious Disease Clinics of North America. 2021 Jun 1;35(2):493–514. Recent review on cryptococcosis infection including recent classification and clinical presentations.CrossRef
95.
Mukaremera L, Nielsen K. Adaptive immunity to Cryptococcus neoformans infections. Journal of Fungi 2017, Vol 3, Page 64 [Internet]. 2017 Nov 21 [cited 2021 Oct 11];3(4):64.
96.
Lizarazo J, Escandón P, Agudelo CI, Castañeda E. Cryptococcosis in Colombian children and literature review. Memórias do Instituto Oswaldo Cruz [Internet]. 2014 Sep 1 [cited 2021 Oct 11];109(6):797–804.
97.
Lizarazo J, Escandón P, Agudelo CI, Castañeda E. Cryptococcosis in Colombian children and literature review. Memórias do Instituto Oswaldo Cruz [Internet]. 2014 Sep 1 [cited 2021 Oct 7];109(6):797–804.
98.
Meya DB, Okurut S, Zziwa G, Rolfes MA, Kelsey M, Cose S, et al. Cellular immune activation in cerebrospinal fluid from Ugandans with cryptococcal meningitis and immune reconstitution inflammatory syndrome. The Journal of Infectious Diseases [Internet]. 2015 May 15 [cited 2021 Oct 7];211(10):1597–606.
99.
Rajasingham R, Wake RM, Beyene T, Katende A, Letang E, Boulware DR. Cryptococcal meningitis diagnostics and screening in the era of point-of-care laboratory testing. Journal of Clinical Microbiology [Internet]. 2019 Jan 1 [cited 2021 Oct 7];57(1).
100.
Boulware DR, Meya DB, Muzoora C, Rolfes MA, Huppler Hullsiek K, Musubire A, et al. Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis. http://​dx.​doi.​org/​https://​doi.​org/​10.​1056/​NEJMoa1312884 [Internet]. 2014 Jun 25 [cited 2021 Oct 7];370(26):2487–98.
101.
Rolfes MA, Hullsiek KH, Rhein J, Nabeta HW, Taseera K, Schutz C, et al. The effect of therapeutic lumbar punctures on acute mortality from cryptococcal meningitis. Clinical Infectious Diseases [Internet]. 2014 Dec 1 [cited 2021 Oct 7];59(11):1607–14.
102.
Wheat J, Myint T, Guo Y, Kemmer P, Hage C, Terry C, et al. Central nervous system histoplasmosis. Medicine (United States). 2018;97(13):1–8.
103.
López LF, Valencia Y, Tobón ÁM, Velásquez O, Santa CD, Cáceres DH, et al. Childhood histoplasmosis in Colombia: clinical and laboratory observations of 45 patients. Med Mycol. 2016;54(7):677–83.CrossRef
104.
Bloch KC, Myint T, Raymond-Guillen L, Hage CA, Davis TE, Wright PW, et al. Improvement in diagnosis of histoplasma meningitis by combined testing for histoplasma antigen and immunoglobulin g and immunoglobulin M anti-histoplasma antibody in cerebrospinal fluid. Clin Infect Dis. 2018;66(1):89–94.CrossRef
105.
Johnson RH, Sharma R, Kuran R, Fong I, Heidari A. Coccidioidomycosis: a review. Journal of Investigative Medicine [Internet]. 2021 Feb 1 [cited 2021 Oct 6];69(2):316–23.
106.
107.
Cárdenas G, Aristizábal S, Salinas C, Delgado-Hernández R, Angeles-Morales V, Soto-Hernández J, et al. Coccidioidal meningitis in non-AIDS patients. A case series at a Mexican neurological referral center. Clinical Neurology and Neurosurgery. 2020 Sep 1;196:106011.
108.
Kassis C, Zaidi S, Kuberski T, Moran A, Gonzalez O, Hussain S, et al. Role of coccidioides antigen testing in the cerebrospinal fluid for the diagnosis of coccidioidal meningitis. Clinical Infectious Diseases [Internet]. 2015 Nov 15 [cited 2021 Nov 15];61(10):1521–6.
Metadaten
Titel
Central Nervous System Fungal Infections in Paediatric Patients
verfasst von
Deborah Palacios-Reyes
Ángeles Costta-Michuy
Tania M. Vargas-Vázquez
M. Vanessa Martínez-Astudillo
Rafael Oscar Santamaría Vásquez
Nancy E. Aguilar-Gómez
Astrid A. Hernandez-Soto
Sofia Fortes-Gutiérrez
Daniel Reyes-Gutierrez
Dania J. Juárez-Padilla
Silvia Fuentes-Soliz
Publikationsdatum
30.01.2022
Verlag
Springer US
Erschienen in
Current Fungal Infection Reports / Ausgabe 1/2022
Print ISSN: 1936-3761
Elektronische ISSN: 1936-377X
DOI
https://doi.org/10.1007/s12281-021-00427-5

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