Skip to main content
Erschienen in: Acta Neuropathologica 3/2011

01.09.2011 | Correspondence

Central nervous system pathology in fatal swine-origin influenza A H1N1 virus infection in patients with and without neurological symptoms: an autopsy study of 15 cases

verfasst von: Abir Mukherjee, Jo Elle G. Peterson, Glenn Sandberg, Hidehiro Takei, Adekunle Adesina, J. C. Goodman, Suzanne Powell

Erschienen in: Acta Neuropathologica | Ausgabe 3/2011

Einloggen, um Zugang zu erhalten

Excerpt

The first influenza pandemic of the twenty-first century was caused by a swine-origin, influenza A (H1N1) virus that contained genes from human, swine, and avian influenza A viruses [4]. It has long been recognized that a small subset of influenza patients develops neurologic complications [1]. Central nervous system (CNS) pathology in influenza virus infection is thought to be indirect and multifactorial [15] and whether H1N1 infects the brain or cerebrospinal fluid (CSF) remains controversial [2]. The current model is that H1N1 triggers a cytokine storm that disrupts the blood–brain barrier and activates glial cells. Subsequent disseminated intravascular coagulation (DIC) and liver and renal dysfunction triggered by hypercytokinemia may also contribute to CNS damage [15]. …
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Anonymous (1970) Neurological complications of influenza. Br Med J 1:248–249 Anonymous (1970) Neurological complications of influenza. Br Med J 1:248–249
2.
Zurück zum Zitat Centers for Disease Control and Prevention (2009) Neurologic complications associated with novel influenza A (H1N1) virus infection in children—Dallas, Texas, May 2009. MMWR 58:773–779 Centers for Disease Control and Prevention (2009) Neurologic complications associated with novel influenza A (H1N1) virus infection in children—Dallas, Texas, May 2009. MMWR 58:773–779
3.
Zurück zum Zitat Chaves-Carballo E, Montes JE, Nelson WB, Chrenka BA (1990) Hemorrhagic shock and encephalopathy. Clinical definition of a catastrophic syndrome in infants. Am J Dis Child 144:1079–1082PubMed Chaves-Carballo E, Montes JE, Nelson WB, Chrenka BA (1990) Hemorrhagic shock and encephalopathy. Clinical definition of a catastrophic syndrome in infants. Am J Dis Child 144:1079–1082PubMed
4.
Zurück zum Zitat Dawood FS, Jain S, Finelli L et al (2009) Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med 360:2605–2615PubMedCrossRef Dawood FS, Jain S, Finelli L et al (2009) Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med 360:2605–2615PubMedCrossRef
5.
Zurück zum Zitat Glasgow JF (1984) Clinical features and prognosis of Reye’s syndrome. Arch Dis Child 59:230–235PubMedCrossRef Glasgow JF (1984) Clinical features and prognosis of Reye’s syndrome. Arch Dis Child 59:230–235PubMedCrossRef
6.
Zurück zum Zitat Lassmann H (2010) Acute disseminated encephalomyelitis and multiple sclerosis. Brain 133:317–319PubMedCrossRef Lassmann H (2010) Acute disseminated encephalomyelitis and multiple sclerosis. Brain 133:317–319PubMedCrossRef
7.
Zurück zum Zitat Martin A, Reade EP (2010) Acute necrotizing encephalopathy progressing to brain death in a pediatric patient with novel influenza A (H1N1) infection. Clin Infect Dis 50:e50–e52PubMedCrossRef Martin A, Reade EP (2010) Acute necrotizing encephalopathy progressing to brain death in a pediatric patient with novel influenza A (H1N1) infection. Clin Infect Dis 50:e50–e52PubMedCrossRef
8.
Zurück zum Zitat Mizuguchi M, Abe J, Mikkaichi K et al (1995) Acute necrotising encephalopathy of childhood: a new syndrome presenting with multifocal, symmetric brain lesions. J Neurol Neurosurg Psychiatry 58:555–561PubMedCrossRef Mizuguchi M, Abe J, Mikkaichi K et al (1995) Acute necrotising encephalopathy of childhood: a new syndrome presenting with multifocal, symmetric brain lesions. J Neurol Neurosurg Psychiatry 58:555–561PubMedCrossRef
9.
Zurück zum Zitat National Center for Health Statistics HDI (2009) Interim Guidance on Specimen Collection, Processing, and Testing for Patients with Suspected Novel Influenza A (H1N1) Virus Infection National Center for Health Statistics HDI (2009) Interim Guidance on Specimen Collection, Processing, and Testing for Patients with Suspected Novel Influenza A (H1N1) Virus Infection
10.
Zurück zum Zitat Neilson DE, Adams MD, Orr CM et al (2009) Infection-triggered familial or recurrent cases of acute necrotizing encephalopathy caused by mutations in a component of the nuclear pore, RANBP2. Am J Hum Genet 84:44–51PubMedCrossRef Neilson DE, Adams MD, Orr CM et al (2009) Infection-triggered familial or recurrent cases of acute necrotizing encephalopathy caused by mutations in a component of the nuclear pore, RANBP2. Am J Hum Genet 84:44–51PubMedCrossRef
11.
Zurück zum Zitat Rothberg MB, Haessler SD (2010) Complications of seasonal and pandemic influenza. Crit Care Med 38:e91–e97PubMedCrossRef Rothberg MB, Haessler SD (2010) Complications of seasonal and pandemic influenza. Crit Care Med 38:e91–e97PubMedCrossRef
12.
Zurück zum Zitat Sato A, Mizuguchi M, Mimaki M et al (2009) Cortical gray matter lesions in acute encephalopathy with febrile convulsive status epilepticus. Brain Dev 31:622–624PubMedCrossRef Sato A, Mizuguchi M, Mimaki M et al (2009) Cortical gray matter lesions in acute encephalopathy with febrile convulsive status epilepticus. Brain Dev 31:622–624PubMedCrossRef
13.
Zurück zum Zitat Visentin M, Salmona M, Tacconi MT (1995) Reye’s and Reye-like syndromes, drug-related diseases? (causative agents, etiology, pathogenesis, and therapeutic approaches). Drug Metab Rev 27:517–539PubMedCrossRef Visentin M, Salmona M, Tacconi MT (1995) Reye’s and Reye-like syndromes, drug-related diseases? (causative agents, etiology, pathogenesis, and therapeutic approaches). Drug Metab Rev 27:517–539PubMedCrossRef
14.
Zurück zum Zitat Wang G, Zhang J, Li W et al (2008) Apoptosis and proinflammatory cytokine responses of primary mouse microglia and astrocytes induced by human H1N1 and avian H5N1 influenza viruses. Cell Mol Immunol 5:113–120PubMedCrossRef Wang G, Zhang J, Li W et al (2008) Apoptosis and proinflammatory cytokine responses of primary mouse microglia and astrocytes induced by human H1N1 and avian H5N1 influenza viruses. Cell Mol Immunol 5:113–120PubMedCrossRef
15.
Zurück zum Zitat Wang GF, Li W, Li K (2010) Acute encephalopathy and encephalitis caused by influenza virus infection. Curr Opin Neurol 23:305–311PubMedCrossRef Wang GF, Li W, Li K (2010) Acute encephalopathy and encephalitis caused by influenza virus infection. Curr Opin Neurol 23:305–311PubMedCrossRef
16.
Zurück zum Zitat Weitkamp JH, Spring MD, Brogan T, Moses H, Bloch KC, Wright PF (2004) Influenza A virus-associated acute necrotizing encephalopathy in the United States. Pediatr Infect Dis J 23:259–263PubMedCrossRef Weitkamp JH, Spring MD, Brogan T, Moses H, Bloch KC, Wright PF (2004) Influenza A virus-associated acute necrotizing encephalopathy in the United States. Pediatr Infect Dis J 23:259–263PubMedCrossRef
Metadaten
Titel
Central nervous system pathology in fatal swine-origin influenza A H1N1 virus infection in patients with and without neurological symptoms: an autopsy study of 15 cases
verfasst von
Abir Mukherjee
Jo Elle G. Peterson
Glenn Sandberg
Hidehiro Takei
Adekunle Adesina
J. C. Goodman
Suzanne Powell
Publikationsdatum
01.09.2011
Verlag
Springer-Verlag
Erschienen in
Acta Neuropathologica / Ausgabe 3/2011
Print ISSN: 0001-6322
Elektronische ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-011-0854-7

Weitere Artikel der Ausgabe 3/2011

Acta Neuropathologica 3/2011 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Viel Bewegung in der Parkinsonforschung

25.04.2024 Parkinson-Krankheit Nachrichten

Neue arznei- und zellbasierte Ansätze, Frühdiagnose mit Bewegungssensoren, Rückenmarkstimulation gegen Gehblockaden – in der Parkinsonforschung tut sich einiges. Auf dem Deutschen Parkinsonkongress ging es auch viel um technische Innovationen.

Demenzkranke durch Antipsychotika vielfach gefährdet

23.04.2024 Demenz Nachrichten

Wenn Demenzkranke aufgrund von Symptomen wie Agitation oder Aggressivität mit Antipsychotika behandelt werden, sind damit offenbar noch mehr Risiken verbunden als bislang angenommen.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.