Erschienen in:
01.09.2011 | Correspondence
Central nervous system pathology in fatal swine-origin influenza A H1N1 virus infection in patients with and without neurological symptoms: an autopsy study of 15 cases
verfasst von:
Abir Mukherjee, Jo Elle G. Peterson, Glenn Sandberg, Hidehiro Takei, Adekunle Adesina, J. C. Goodman, Suzanne Powell
Erschienen in:
Acta Neuropathologica
|
Ausgabe 3/2011
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Excerpt
The first influenza pandemic of the twenty-first century was caused by a swine-origin, influenza A (H1N1) virus that contained genes from human, swine, and avian influenza A viruses [
4]. It has long been recognized that a small subset of influenza patients develops neurologic complications [
1]. Central nervous system (CNS) pathology in influenza virus infection is thought to be indirect and multifactorial [
15] and whether H1N1 infects the brain or cerebrospinal fluid (CSF) remains controversial [
2]. The current model is that H1N1 triggers a cytokine storm that disrupts the blood–brain barrier and activates glial cells. Subsequent disseminated intravascular coagulation (DIC) and liver and renal dysfunction triggered by hypercytokinemia may also contribute to CNS damage [
15]. …