Introduction
Patients and methods
Non-demented disease controls
Neurological diseases without organic brain affection
Depressive cognitive complainers
Patients with Alzheimer’s disease
Patients with frontotemporal dementia
Preanalytical treatment of CSF for Aβ-SDS-PAGE immunoblot
Aβ-SDS-PAGE/immunoblot
Statistical analysis
Results
Diagnosis | NDC (n = 20) | AD (n = 22) | FTD (n = 17) | |||
---|---|---|---|---|---|---|
Mean | ±SD | Mean | ±SD | Mean | ±SD | |
Age | 59.1 | 11.7 | 70.8 | 8.6 | 62.8 | 5.7 |
MMSE | 28.6 | 0.5 | 22.5 | 4.4 | 20.9 | 9.9 |
Aβ1-37a
| 0.926 | 0.336 | 0.849 | 0.255 | 0.799 | 0.532 |
Aβ1-38a
| 2.261 | 0.787 | 2.257 | 0.554 | 1.433 | 0.554 |
Aβ1-38ox
a
| 0.149 | 0.045 | 0.146 | 0.039 | 0.124 | 0.040 |
Aβ1-39a
| 0.959 | 0.343 | 0.944 | 0.312 | 0.798 | 0.487 |
Aβ1-40a
| 7.142 | 2.868 | 6.246 | 2.287 | 5.108 | 2.967 |
Aβ1-40ox
a
| 0.229 | 0.108 | 0.209 | 0.071 | 0.212 | 0.103 |
Aβ1-42a
| 1.521 | 0.604 | 0.702 | 0.302 | 1.056 | 0.631 |
Aβ2-40a
| 0.156 | 0.026 | 0.143 | 0.042 | 0.124 | 0.052 |
Aβ2-42a
| 0.242 | 0.162 | 0.091 | 0.054 | 0.188 | 0.097 |
Aβ1-42/Aβ1-40b
| 0.228 | 0.088 | 0.122 | 0.050 | 0.220 | 0.103 |
Aβ1-42/Aβ1-38b
| 0.693 | 0.222 | 0.327 | 0.168 | 0.727 | 0.317 |
Aβ2-42/Aβ1-40b
| 0.040 | 0.026 | 0.014 | 0.009 | 0.040 | 0.015 |
Aβ2-42/Aβ1-38b
| 0.108 | 0.047 | 0.040 | 0.017 | 0.118 | 0.050 |
Correlations
Group differences
Neurochemical phenotype of AD versus NDC
Neurochemical phenotype of FTD versus NDC
Neurochemical phenotype of AD versus FTD
Neurochemically supported differential diagnosis of AD versus FTD
Differential diagnosis | Parameter | Cut off | Sensitivity (%) | Specificity (%) | Youden index | AUC | 95 % CI |
---|---|---|---|---|---|---|---|
AD versus FTD | Aβ1-42 | 1.02 | 95 | 53 | 0.48 | 0.674 | 0.489–0.858 |
Aβ1-42/1-40 | 0.19 | 91 | 65 | 0.56 | 0.797 | 0.653–0.941 | |
Aβ1-42/1-38 | 0.45 | 82 | 82 | 0.64 | 0.917 | 0.835–0.999 | |
Aβ2-42 | 0.11 | 91 | 89 | 0.80 | 0.859 | 0.671–1.00 | |
Aβ2-42/1-40 | 0.03 | 91 | 89 | 0.80 | 0.929 | 0.805–1.00 | |
Aβ2-42/1-38 | 0.08 | 100 | 89 | 0.89 | 0.929 | 0.792–1.00 |