Background
Methods
Participants
Pre-operative examinations
Surgical technique
Post-operative examinations and topical eye drops usage
Data analysis and statistical evaluation
Results
Variables | Pre-operative | Postoperative 24 h | F valuea | P value | ||
---|---|---|---|---|---|---|
Mean ± SD | Range | Mean ± SD | Range | |||
Age (year) | 28.4 ± 7.1 | 18 to 42 | 28.4 ± 7.1 | 18 to 42 | – | – |
MRSE (D) | −6.76 ± 1.39 | −10.00 to −4.13 | −0.22 ± 0.48 | −1.38 to 0.75 | 508.580 | <0.001b |
K1 (D) | 43.23 ± 1.40 | 40.1 to 45.2 | 38.35 ± 2.12 | 32.3 to 40.9 | 510.718 | <0.001b |
K2 (D) | 44.56 ± 1.84 | 41.0 to 47.6 | 39.03 ± 2.23 | 32.7 to 42.3 | 557.309 | <0.001b |
Km (D) | 43.88 ± 1.54 | 40.6 to 46.4 | 38.69 ± 2.15 | 32.5 to 41.6 | 622.613 | <0.001b |
Pentacam-CCT (μm) | 546.6 ± 23.4 | 515 to 592 | 431.9 ± 28.0 | 399 to 501 | 521.421 | <0.001b |
IOP measurements
Variables | Pre-operative | Postoperative 20 min | Postoperative 24 h | F valuea | P value | |||
---|---|---|---|---|---|---|---|---|
Mean ± SD | Range | Mean ± SD | Range | Mean ± SD | Range | |||
NCT-IOP (mmHg) | 15.04 ± 2.91 | 11.1 to 20.9 | 9.19 ± 2.52 | 4.6 to 15.2 | 9.70 ± 2.95 | 5.8 to 17.2 | 81.173 | <0.001b |
IOPcc (mmHg) | 14.99 ± 2.46 | 10.2 to 19.0 | 16.65 ± 4.29 | 12.1 to 29.4 | 14.01 ± 3.10 | 6.8 to 20.3 | 4.975 | 0.030b |
IOPg (mmHg) | 15.10 ± 3.21 | 9.3 to 21.9 | 11.20 ± 3.38 | 4.7 to 18.2 | 9.52 ± 2.85 | 4.5 to 15.9 | 40.128 | <0.001b |
CST-IOP (mmHg) | 17.74 ± 2.16 | 13.0 to 23.0 | 14.29 ± 2.09 | 10.0 to 17.5 | 14.57 ± 1.58 | 10.5 to 18.0 | 31.886 | <0.001b |
Changes in corneal biomechanical and deformation parameters
Abbreviation | Definition |
---|---|
AT1 | Applination Time (time 1): the duration from the initiation to the moment that a cornea just deformed for the first time |
ATh | Applination Time (hightest concavity): the duration from the initiation to the moment that a cornea is depressed to the highest concavity |
AT2 | Applination Time (time 2): the duration from the initiation to the moment that a corneal deformation just completely resumed |
AL1 | Applination length (time 1): the cord length recorded at the moment that a cornea just deformed for the first time |
AL2 | Applination length (time 2): the cord length recorded at the moment that a corneal deformation just completely resumed |
AV1 | Applination velocity (time 1): the instantaneous velocity recorded when a cornea just deformed |
AV2 | Applination velocity (time 2): the instantaneous velocity recorded when a cornea just completely resumed |
Radius | Radius: the corneal radius obtained when a cornea is depressed to the highest concavity |
PD | Peak Distance: the distance between the two corneal peaks recorded when a cornea is depressed to the highest concavity |
DA | Deformation Amplitude: the maximum amplitude of corneal deformation recorded when a cornea is depressed to the highest concavity |
Variables | Pre-operative | Postoperative 20 min | Postoperative 24 h | F valuea | P value | |||
---|---|---|---|---|---|---|---|---|
Mean ± SD | Range | Mean ± SD | Range | Mean ± SD | Range | |||
CH (mmHg) | 11.05 ± 1.81 | 8.7 to 16.7 | 6.82 ± 0.98 | 5.3 to 8.4 | 7.49 ± 1.32 | 5.6 to 11.0 | 90.283 | <0.001b |
CRF (mmHg) | 10.84 ± 2.20 | 7.1 to 17.3 | 6.07 ± 1.26 | 2.9 to 9.3 | 6.09 ± 1.27 | 4.1 to 9.1 | 131.239 | <0.001b |
CST-CCT (μm) | 545.8 ± 24.8 | 515.0 to 618.0 | 469.7 ± 46.4 | 389 to 580 | 440.9 ± 29.5 | 407 to 522 | 136.093 | <0.001b |
AT1 (ms) | 7.28 ± 0.26 | 6.71 to 7.97 | 6.91 ± 0.23 | 6.52 to 7.32 | 6.90 ± 0.18 | 6.54 to 7.37 | 36.484 | <0.001b |
ATh (ms) | 16.94 ± 0.53 | 16.17 to 17.79 | 16.77 ± 0.86 | 14.32 to 18.02 | 16.94 ± 0.63 | 15.71 to 18.02 | 0.465 | 0.631 |
AT2 (ms) | 21.64 ± 1.29 | 16.89 to 22.82 | 22.13 ± 0.41 | 21.36 to 22.86 | 22.17 ± 0.29 | 21.61 to 22.87 | 3.042 | 0.089 |
AL1 (mm) | 1.78 ± 0.04 | 1.71 to 1.87 | 1.72 ± 0.17 | 1.26 to 1.92 | 1.74 ± 0.20 | 1.19 to 1.94 | 0.798 | 0.429 |
AL2 (mm) | 1.49 ± 0.39 | 0.44 to 2.00 | 1.35 ± 0.44 | 0.73 to 2.00 | 1.22 ± 0.41 | 0.73 to 1.89 | 2.281 | 0.131 |
AV1 (m/s) | 0.16 ± 0.02 | 0.09 to 0.22 | 0.14 ± 0.02 | 0.08 to 0.19 | 0.15 ± 0.02 | 0.11 to 0.20 | 5.528 | 0.007b |
AV2 (m/s) | −0.44 ± 0.14 | −0.92 to −0.20 | −0.56 ± 0.13 | −0.75 to −0.33 | −0.61 ± 0.16 | −1.11 to −0.33 | 8.910 | 0.001b |
PD (mm) | 4.27 ± 1.19 | 2.36 to 5.43 | 4.51 ± 1.25 | 2.62 to 6.19 | 4.53 ± 1.27 | 2.57 to 6.23 | 0.355 | 0.704 |
Radius (mm) | 6.97 ± 1.46 | 1.66 to 9.45 | 5.51 ± 1.00 | 1.78 to 6.88 | 5.69 ± 0.54 | 4.89 to 7.05 | 13.208 | <0.001b |
DA (mm) | 1.09 ± 0.09 | 0.89 to 1.37 | 1.17 ± 0.10 | 1.03 to 1.43 | 1.14 ± 0.07 | 0.99 to 1.34 | 10.100 | <0.001b |
Correlations
Stepwise multiple linear regression models
Dependent Variables | Main Predictors | Ba | SEb | tc | Sig. | βd | Regression Equation | Adjusted R2 | Fe | Sig. |
---|---|---|---|---|---|---|---|---|---|---|
Pre-op NCT-IOP | Practical postop NCT-IOP | 0.646 | 0.167 | 3.873 | <0.001 | 0.655 | Theoretical post-op NCT-IOP (mmHg) = 0.646 × Practical post-op NCT-IOP(mmHg) + 8.774(mmHg) | 0.400 | 15.000 | <0.001 |
Constant | 8.774 | 1.688 | 5.198 | 0.001 | - | |||||
Pre-op ORAIOPcc | Practical postop IOPcc | 0.558 | 0.126 | 4.445 | <0.001 | 0.705 | Theoretical post-op IOPcc (mmHg) = 0.558 × practical postoperative IOPcc (mmHg) + 7.166(mmHg) | 0.472 | 19.755 | <0.001 |
Constant | 7.166 | 1.800 | 3.981 | 0.001 | - | |||||
Pre-op ORAIOPg | Practical postopIOPg | 0.848 | 0.167 | 5.084 | <0.001 | 0.751 | Theoretical post-op IOPg (mmHg) = 0.848 × practical postoperative IOPg (mmHg) + 7.024 (mmHg) | 0.542 | 25.850 | <0.001 |
Constant | 7.024 | 1.654 | 4.247 | <0.001 | - | |||||
Pre-op CST-IOP | Post-op AT1 | 8.079 | 1.660 | 4.866 | <0.001 | 0.680 | Theoretical post-op CST-IOP (mmHg) = 8.079 × post-op AT1 (ms) + 0.035 × pre-op CCT(μm) + 0.515 × post-op PD (mm) - 59.47 mmHg | 0.596 | 11.336 | <0.001 |
Pre-op CCT | 0.035 | 0.013 | 2.732 | 0.014 | 0.379 | |||||
Post-op PD | 0.515 | 0.237 | 2.176 | 0.043 | 0.304 | |||||
Constant | −59.47 | 13.524 | −4.397 | <0.001 | - |