Erschienen in:
12.04.2021 | Original Contributions
Changes of Carotid Intima-Media Thickness After Sleeve Gastrectomy in High Cardiovascular Risk Patients: a Prospective Study
verfasst von:
Mohamed Abdalla Salman, Ahmed Abdallah Salman, Mohammad El Sherbiny, Shaimaa Elkholy, Ahmed Youssef, Safa Labib, Mohamed Tag El-Din, Khaled A Monazea, Mohamed Sabry Tourky, Hani Maurice Sabri Mikhail, Karim K Maurice, Ahmed Abdallah, Mohamed Saber Mostafa, Ahmed Mahmoud Hussein, Ahmed Mohammed Abdelsalam, Nesrin Abd Allah, Amr M. Ismaeel Saadawy, Hossam El-Din Shaaban, Mohamed D. Sarhan
Erschienen in:
Obesity Surgery
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Ausgabe 8/2021
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Abstract
Purpose
There are insufficient data showing the impact of laparoscopic sleeve gastrectomy (LSG) on carotid intima-media thickness (CIMT). Therefore, in the current work, we investigated the improvement of metabolic syndrome and CIMT in patients with obesity after LSG.
Methods
This study involved 120 consecutively selected Egyptian patients with a high cardiovascular risk who underwent LSG and were followed up for 12 months.
Results
CIMT declined from 0.95 ± 0.17 mm to 0.83 ± 0.12 (p < 0.001) after 12 months. In addition, the mean fasting blood glucose and fasting inulin level dropped significantly from 153.3 ± 63.6 to 108.8 ± 33.8 mg/dl and from 23.1 ± 7.1 mU/ml to 14.1 ± 6.4 respectively (p < 0.001). Furthermore, glycated hemoglobin (HbA1c) declined from 7.02 ± 1.7 to 5.5 ± 0.96 (p < 0.001). At the end of the follow-up period, metabolic parameters such as HOMA-IR, C-reactive protein (CRP), fibrinogen, total cholesterol, LDL cholesterol, triglycerides, AST, and ALT decreased significantly from their respective baselines (p value < 0.001). Moreover, the reduction in CIMT showed a strong positive correlation with the degree of weight loss at 6 months and 12 months of follow-up.
Conclusion
LSG led to a substantial decrease in CIMT. Moreover, it significantly impacted cardiovascular risk factors such as obesity, hypertension, insulin resistance, lipid profile, and inflammatory markers.