Erschienen in:
01.04.2011 | Brief Report
Characterization of rabies virus from a human case in Nepal
verfasst von:
G. R. Pant, D. L. Horton, M. Dahal, J. N. Rai, S. Ide, S. Leech, D. A. Marston, L. M. McElhinney, A. R. Fooks
Erschienen in:
Archives of Virology
|
Ausgabe 4/2011
Einloggen, um Zugang zu erhalten
Abstract
Rabies is endemic throughout most of Asia, with the majority of human cases transmitted by domestic dogs (Canis familiaris). Here, we report a case of rabies in a 12-year-old girl in the Lalitpur district of Nepal that might have been prevented by better public awareness and timely post-exposure prophylaxis. Molecular characterization of the virus showed 100% identity over a partial nucleoprotein gene sequence to previous isolates from Nepal belonging to the ‘arctic-like’ lineage of rabies virus. Sequence analysis of both partial nucleoprotein and glycoprotein genes showed differences in consensus sequence after passage in vitro but not after passage in vivo.