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Journal of Natural Medicines

Erschienen in:

01.04.2016 | Original Paper

Chemical constituents with anti-allergic activity from the root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora

verfasst von: Yan-Hong Shi, Shu Zhu, Takayuki Tamura, Makoto Kadowaki, Zhengtao Wang, Kayo Yoshimatsu, Katsuko Komatsu

Erschienen in: Journal of Natural Medicines | Ausgabe 2/2016

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Abstract

The methanolic extract and its subfractions from the dried root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora Pallas, showed potent anti-allergic effect as inhibition of immunoglobulin E (IgE)-mediated degranulation in rat basophil leukemia (RBL)-2H3 cells. Bioassay-guided fractionation led to the isolation of 26 compounds, including a new norneolignan glycoside, paeonibenzofuran (1), together with 25 known ones (2–26). The chemical structure of the new compound was elucidated on the basis of spectroscopic and chemical evidences. Among the isolated compounds, mudanpioside E (5) with paeoniflorin-type skeleton and quercetin (16) showed potent inhibitory activity against a degranulation marker, β-hexosaminidase release with IC₅₀ values of 40.34 and 25.05 μM, respectively. A primary structure–activity relationship of these components was discussed.

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Titel: Chemical constituents with anti-allergic activity from the root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora
verfasst von: Yan-Hong Shi
Shu Zhu
Takayuki Tamura
Makoto Kadowaki
Zhengtao Wang
Kayo Yoshimatsu
Katsuko Komatsu
Publikationsdatum: 01.04.2016
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 2/2016
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-016-0966-4

Springer Medizin

Abstract

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