Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Annals of Surgical Oncology
Erschienen in: Annals of Surgical Oncology 2/2009

01.02.2009 | Laboratory and Translational Research

Chemoprotective Effects of Curcuma aromatica on Esophageal Carcinogenesis

verfasst von: Yan Li, MD, PhD, John M. Wo, MD, Qiaohong Liu, MS, Xiaokun Li, MD, PhD, Robert C. G. Martin, MD

Erschienen in: Annals of Surgical Oncology | Ausgabe 2/2009

Einloggen, um Zugang zu erhalten

Abstract

Previous studies have demonstrated a decrease in manganese superoxide dismutase (MnSOD) in both Barrett’s epithelium of patients and columnar esophageal epithelium of rats after esophagoduodenal anastomosis (EDA). Curcuma aromatica, an herbal medicine, has been shown to display anti-carcinogenic properties in a wide variety of cell lines and animals. This study was designed to investigate the ability of Curcuma aromatica oil for the prevention of BE and EAC, possibly through its ability to preserve MnSOD function. EDA was performed on rats and Curcuma aromatica oil was administered by i.p. injection. Histological changes and oxidative damage were determined after EDA of 1, 3, and 6 months. MnSOD protein level and MnSOD enzymatic activity were evaluated. Lipid peroxidation was determined by TBARs assay and 8-hydroxy-deoxyguanosine for DNA oxidative damage was measured by immunohistochemical staining. In addition, the indexes of both apoptosis and proliferation were determined by PCNA staining and TUNEL assay, respectively. Severe esophagitis were seen in EDA rats, and morphological transformation within the esophageal epithelium was observed with intestinal metaplasia and EAC identified after 3 months. The EDA rats treated with Curcuma aromatica oil showed that both MnSOD enzymatic activity and protein level were similar to sham controls. Decreased incidences of intestinal metaplasia and EAC also were observed in the EDA rats with Curcuma aromatica oil treatment. Curcuma aromatica oil prevented loss of MnSOD in EDA rat esophageal epithelium, and this preservation of MnSOD is associated with the potential protective mechanism against transformation of esophageal epithelial to BE to EAC.
Literatur
1.
Li Y, Wo JM, Su RR, Ray MB, Jones W, Martin RC. Esophageal injury with external esophageal perfusion. J Surg Res. 2005;129:107–13.PubMedCrossRef
2.
Li Y, Wo JM, Ellis S, Ray MB, Jones W, Martin RC. A novel external esophageal perfusion model for reflux esophageal injury. Dig Dis Sci. 2006;51:527–32.PubMedCrossRef
3.
Li Y, Wo JM, Ellis S, Ray MB, Jones W, Martin RC. Morphological transformation in esophageal submucosa by bone marrow cells: esophageal implantation under external esophageal perfusion. Stem Cells Dev. 2006;15:697–705.PubMedCrossRef
4.
Li Y, Wo JM, Su RR, Ray MB, Martin RC. Alterations in manganese superoxide dismutase expression in the progression from reflux esophagitis to esophageal adenocarcinoma. Ann Surg Oncol. 2007;14:2045–55.PubMedCrossRef
5.
Davies KJA. Oxidative stress, antioxidant defenses, and damage removal, repair, and replacement systems. Iubmb Life. 2000;50:279–89.PubMedCrossRef
6.
Chen XX, Yang CS. Esophageal adenocarcinoma: a review and perspectives on the mechanism of carcinogenesis and chemoprevention. Carcinogenesis. 2001;22:1119–29.PubMedCrossRef
7.
Li B, Liang N. Advances in the clinical application and experimental study of Curcuma zedoaria oil preparations. Zhong Yao Cai. 2003;26:68–71.PubMed
8.
Ramirez-Tortosa MC, Mesa MD, Aguilera MC, Quiles JL, Baro L, Ramirez-Tortosa CL, et al. Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis. Atherosclerosis. 1999;147:371–8.PubMedCrossRef
9.
Quiles JL, Mesa MD, Ramirez-Tortosa CL, Aguilera CM, Battino M, Gil A, et al. Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits. Arterioscler Thromb Vasc Biol. 2002;22:1225–31.PubMedCrossRef
10.
Rajakrishnan V, Viswanathan P, Rajasekharan KN, Menon VP. Neuroprotective role of curcumin from Curcuma longa on ethanol-induced brain damage. Phytother Res. 1999;13:571–4.PubMedCrossRef
11.
Ramirez-Bosca A, Soler A, Carrion MA, Diaz-Alperi J, Bernd A, Quintanilla C, et al. An hydroalcoholic extract of Curcuma longa lowers the apo B/apo A ratio. Implications for atherogenesis prevention. Mech Ageing Dev. 2000;119:41–7.PubMedCrossRef
12.
Jee SH, Shen SC, Tseng CR, Chiu HC, Kuo ML. Curcumin induces a p53-dependent apoptosis in human basal cell carcinoma cells. J Invest Dermatol. 1998;111:656–61.PubMedCrossRef
13.
Huang MT, Lou YR, Ma W, Newmark HL, Reuhl KR, Conney AH. Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice. Cancer Res. 1994;54:5841–7.PubMed
14.
Ruby AJ, Kuttan G, Babu KD, Rajasekharan KN, Kuttan R. Anti-tumour and antioxidant activity of natural curcuminoids. Cancer Lett. 1995;94:79–83.PubMedCrossRef
15.
Jiang Y, Li ZS, Jiang FS, Deng X, Yao CS, Nie G. Effects of different ingredients of zedoary on gene expression of HSC-T6 cells. World J Gastroenterol. 2005;11:6780–6.PubMed
16.
Deng SG, Wu ZF, Li WY, Yang ZG, Chang G, Meng FZ, et al. Safety of Curcuma aromatica oil gelatin microspheres administered via hepatic artery. World J Gastroenterol. 2004;10:2637–42.PubMed
17.
Buttar NS, Wang KK, Leontovich O, Westcott JY, Pacifico RJ, Anderson MA, et al. Chemoprevention of esophageal adenocarcinoma by COX-2 inhibitors in an animal model of Barrett’s esophagus. Gastroenterology. 2002;122:1101–12.PubMedCrossRef
18.
Li Y, Wo JM, Su RR, Ray MB, Martin RC. Alterations in manganese superoxide dismutase expression in the progression from reflux esophagitis to esophageal adenocarcinoma. Ann Surg Oncol. 2007;14:2045–55.PubMedCrossRef
19.
Ismail-Beigi F, Horton PF, Pope CE. Histological consequences of gastroesophageal reflux in man. Gastroenterology. 1970;58:163–74.PubMed
20.
Li Y, Wo JM, Su RR, Ray MB, Jones W, Martin RC. Esophageal injury with external esophageal perfusion. J Surg Res. 2005;129:107–13.PubMedCrossRef
21.
Li Y, Wo JM, Ellis S, Ray MB, Jones W, Martin RC. A novel external esophageal perfusion model for reflux esophageal injury. Dig Dis Sci. 2006;51:527–32.PubMedCrossRef
22.
Li Y, Wo JM, Su RR, Ray MB, Martin RC. Alterations in manganese superoxide dismutase expression in the progression from reflux esophagitis to esophageal adenocarcinoma. Ann Surg Oncol. 2007;14:2045–55.PubMedCrossRef
23.
Lev-Ari S, Maimon Y, Strier L, Kazanov D, Arber N. Down-regulation of prostaglandin e2 by curcumin is correlated with inhibition of cell growth and induction of apoptosis in human colon carcinoma cell lines. J Soc Integr Oncol. 2006;4:21–6.PubMed
24.
Shi JH, Li CZ, Liu DL. Experimental research on the pharmacology of Curcuma aromatica volatile oil. Zhong yao Tong bao 1981;6:36–8.
25.
Shiobara Y, Asakawa Y, Kodama M, Yasuda K, Takemoto T. Curcumenone, curcumanolide A and curcumanolide B, three sesquiterpenoids from Curcuma zedoaria. Phytochemistry. 1985;24:2629–33.CrossRef
26.
Xu LY, Tian LQ, Li K, Chen SW, Mao Y. [Study on the volatile oil by SFE-CO, from crude and processed rhizoma atractylodis by GC-MS]. Zhong Yao Cai. 2007;30:16–20.PubMed
27.
Zwaving JH, Bos R. Analysis of the essential oils of five Curcuma species. Flavour Fragrance J. 1991;7:19–22.CrossRef
28.
Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003;23:363–98.PubMed
29.
Wu W, Deng R, Ou Y. [Therapeutic efficacy of microsphere-entrapped Curcuma aromatica oil infused via hepatic artery against transplanted hepatoma in rats]. Zhonghua Gan Zang Bing Za Zhi. 2000;8:24–6.PubMed
30.
Deng SG, Wu ZF, Li WY, Yang ZG, Chang G, Meng FZ, et al. Safety of Curcuma aromatica oil gelatin microspheres administered via hepatic artery. World J Gastroenterol. 2004;10:2637–42.PubMed
31.
Li CZ. [Anti-inflammatory effect of the volatile oil from Curcuma aromatica]. Zhong Yao Tong Bao. 1985;10:38–40.PubMed
32.
Tohda C, Nakayama N, Hatanaka F, Komatsu K. Comparison of anti-inflammatory activities of six Curcuma rhizomes: a possible curcuminoid-independent pathway mediated by Curcuma phaeocaulis extract. Evid Based Complement Alternat Med. 2006;3:255–60.PubMedCrossRef
33.
Makabe H, Maru N, Kuwabara A, Kamo T, Hirota M. Anti-inflammatory sesquiterpenes from Curcuma zedoaria. Nat Prod Res. 2006;20:680–5.PubMedCrossRef
34.
Sodsai A, Piyachaturawat P, Sophasan S, Suksamrarn A, Vongsakul M. Suppression by Curcuma comosa Roxb. of pro-inflammatory cytokine secretion in phorbol-12-myristate-13-acetate stimulated human mononuclear cells. Int Immunopharmacol. 2007;7:524–31.PubMedCrossRef
35.
Funk JL, Frye JB, Oyarzo JN, Kuscuoglu N, Wilson J, McCaffrey G, et al. Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis. Arthritis Rheum. 2006;543452–64.
36.
Lim CS, Jin DQ, Mok H, Oh SJ, Lee JU, Hwang JK, et al. Antioxidant and antiinflammatory activities of xanthorrhizol in hippocampal neurons and primary cultured microglia. J Neurosci Res. 2005;82:831–8.PubMedCrossRef
37.
Wetscher GJ, Hinder RA, Klingler P, Gadenstatter M, Perdikis G, Hinder PR. Reflux esophagitis in humans is a free radical event. Dis Esophagus. 1997;10:29–32.PubMed
38.
Wetscher GJ, Glaser K, Wieschemeyer T, Gadenstatter M, Profanter C. Pathophysiology of the gastroesophageal reflux disease. Chirurgische Gastroenterologie. 1997;13:86–91.CrossRef
39.
Li SD, Mobarhan S. Association between body mass index and adenocarcinoma of the esophagus and gastric cardia. Nutr Rev. 2000;58:54–6.PubMed
40.
Chen XX, Yang GY, Ding WY, Bondoc F, Curtis SK, Yang CS. An esophagogastroduodenal anastomosis model for esophageal adenocarcinogenesis in rats and enhancement by iron overload. Carcinogenesis. 1999;20:1801–7.PubMedCrossRef
41.
Chen XX, Ding YW, Yang GY, Bondoc F, Lee MJ, Yang CS. Oxidative damage in an esophageal adenocarcinoma model with rats. Carcinogenesis. 2000;21:257–63.PubMedCrossRef
42.
Chen XX, Mikhail SS, Ding YW, Yang GY, Bondoc F, Yang CS. Effects of vitamin E and selenium supplementation on esophageal adenocarcinogenesis in a surgical model with rats. Carcinogenesis. 2000;21:1531–6.PubMedCrossRef
43.
Chen XX, Yang CS. Esophageal adenocarcinoma: a review and perspectives on the mechanism of carcinogenesis and chemoprevention. Carcinogenesis. 2001;22:1119–29.PubMedCrossRef
44.
Jankowski JA, Wright NA, Meltzer SJ, Triadafilopoulos G, Geboes K, Casson AG, et al. Molecular evolution of the metaplasia-dysplasia-adenocarcinoma sequence in the esophagus. Am J Pathol. 1999;154:965–73.PubMed
45.
Prach AT, MacDonald TA, Hopwood DA, Johnston DA. Increasing incidence of Barrett’s oesophagus: education, enthusiasm, or epidemiology? Lancet. 1997;350:933.PubMedCrossRef
46.
Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003;23:363–98.PubMed
47.
Lim CS, Jin DQ, Mok H, Oh SJ, Lee JU, Hwang JK, et al. Antioxidant and antiinflammatory activities of xanthorrhizol in hippocampal neurons and primary cultured microglia. J Neurosci Res. 2005;82:831–8.PubMedCrossRef
48.
Selvam R, Subramanian L, Gayathri R, Angayarkanni N. The anti-oxidant activity of turmeric (Curcuma longa). J Ethnopharmacol. 1995;47:59–67.PubMedCrossRef
49.
Shalini VK, Srinivas L. Lipid peroxide induced DNA damage: protection by turmeric (Curcuma longa). Mol Cell Biochem. 1987;77:3–10.PubMedCrossRef
50.
Asai A, Nakagawa K, Miyazawa T. Antioxidative effects of turmeric, rosemary and capsicum extracts on membrane phospholipid peroxidation and liver lipid metabolism in mice. Biosci Biotechnol Biochem. 1999;63:2118–22.PubMedCrossRef
51.
Quiles JL, Mesa MD, Ramirez-Tortosa CL, Aguilera CM, Battino M, Gil A, et al. Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits. Arterioscler Thromb Vasc Biol. 2002;22:1225–31.PubMedCrossRef
52.
Miquel J, Bernd A, Sempere JM., Diaz-Alperi, J, Ramirez A. The curcuma antioxidants: pharmacological effects and prospects for future clinical use. A review. Arch Gerontol Geriatr. 2002; 34:37–46.PubMedCrossRef
53.
Lanas A, Soteras F, Jimenez P, Fiteni I, Piazuelo E, Royo Y, et al. Superoxide anion and nitric oxide in high-grade esophagitis induced by acid and pepsin in rabbits. Dig Dis Sci. 2001;46:2733–43.PubMedCrossRef
54.
Naya MJ, Pereboom D, Ortego J, Alda JO, Lanas A. Superoxide anions produced by inflammatory cells play an important part in the pathogenesis of acid and pepsin induced oesophagitis in rabbits. Gut. 1997;40175–81.
55.
Wetscher GJ, Perdikis G, Kretchmar DH, Stinson RG, Bagchi D, Redmond EJ, et al. Esophagitis in Sprague-Dawley rats is mediated by free-radicals. Dig Dis Sci. 1995;40:1297–305.PubMedCrossRef
56.
Martin RC, Liu Q, Wo JM, Ray MB, Li Y. Chemoprevention of carcinogenic progression to esophageal adenocarcinoma by the manganese superoxide dismutase supplementation. Clin Cancer Res. 2007;13:5176–82.PubMedCrossRef
57.
58.
Sundaresan M, Yu ZX, Ferrans VJ, Irani K, Finkel T. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science. 1995;270:296–9.PubMedCrossRef
59.
Piazuelo E, Cebrian C, Escartin A, Jimenez P, Soteras F, Ortego J, et al. Superoxide dismutase prevents development of adenocarcinoma in a rat model of Barrett’s esophagus. World J Gastroenterol. 2005;11:7436–43.PubMed
60.
Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, et al. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet. 1995;11:376–81.PubMedCrossRef
61.
Sengottuvelan M, Senthilkumar R, Nalini N. Modulatory influence of dietary resveratrol during different phases of 1,2-dimethylhydrazine induced mucosal lipid-peroxidation, antioxidant status and aberrant crypt foci development in rat colon carcinogenesis. Biochim Biophys Acta. 2006;1760:1175–83.PubMed
Metadaten
Titel
Chemoprotective Effects of Curcuma aromatica on Esophageal Carcinogenesis
verfasst von
Yan Li, MD, PhD
John M. Wo, MD
Qiaohong Liu, MS
Xiaokun Li, MD, PhD
Robert C. G. Martin, MD
Publikationsdatum
01.02.2009
Verlag
Springer-Verlag
Erschienen in
Annals of Surgical Oncology / Ausgabe 2/2009
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-008-0228-0

Weitere Artikel der Ausgabe 2/2009

Annals of Surgical Oncology 2/2009 Zur Ausgabe

Gastrointestinal Oncology

Impact of Postoperative Infection on Long-Term Survival After Potentially Curative Resection for Gastric Cancer

Head and Neck Oncology

Positive Sentinel Lymph Nodes are a Negative Prognostic Factor for Survival in T1–2 Oral/Oropharyngeal Cancer: A Long-Term Study on 103 Patients

Endocrine Tumors

Combination Therapy with Histone Deacetylase Inhibitors and Lithium Chloride: A Novel Treatment for Carcinoid Tumors

Hepatobiliary and Pancreatic Tumors

Immunohistochemically Detected Expression of p27Kip1 and Skp2 Predicts Survival in Patients with Intrahepatic Cholangiocarcinomas

Endocrine Tumors

Principal Component Analysis, Hierarchical Clustering, and Decision Tree Assessment of Plasma mRNA and Hormone Levels as an Early Detection Strategy for Small Intestinal Neuroendocrine (Carcinoid) Tumors

Gynecologic Oncology

The Use of Sodium Hyaluronate–Carboxymethylcellulose (HA-CMC) Barrier in Gynecologic Malignancies: A Retrospective Review of Outcomes

Neu im Fachgebiet Chirurgie

Wie erfolgreich ist eine Re-Ablation nach Rezidiv?

23.04.2024 Ablationstherapie Nachrichten

Nach der Katheterablation von Vorhofflimmern kommt es bei etwa einem Drittel der Patienten zu Rezidiven, meist binnen eines Jahres. Wie sich spätere Rückfälle auf die Erfolgschancen einer erneuten Ablation auswirken, haben Schweizer Kardiologen erforscht.

Hinter dieser Appendizitis steckte ein Erreger

23.04.2024 Appendizitis Nachrichten

Schmerzen im Unterbauch, aber sonst nicht viel, was auf eine Appendizitis hindeutete: Ein junger Mann hatte Glück, dass trotzdem eine Laparoskopie mit Appendektomie durchgeführt und der Wurmfortsatz histologisch untersucht wurde.

Mehr Schaden als Nutzen durch präoperatives Aussetzen von GLP-1-Agonisten?

23.04.2024 Operationsvorbereitung Nachrichten

Derzeit wird empfohlen, eine Therapie mit GLP-1-Rezeptoragonisten präoperativ zu unterbrechen. Eine neue Studie nährt jedoch Zweifel an der Notwendigkeit der Maßnahme.

Ureterstriktur: Innovative OP-Technik bewährt sich

19.04.2024 EAU 2024 Kongressbericht

Die Ureterstriktur ist eine relativ seltene Komplikation, trotzdem bedarf sie einer differenzierten Versorgung. In komplexen Fällen wird dies durch die roboterassistierte OP-Technik gewährleistet. Erste Resultate ermutigen.

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Aktuelle BDC Leitlinien-Webinare

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare
CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare
CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare
CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.
Bildnachweise