Polymyositis (PM) is one of the subtypes of the inflammatory myopathies, the pathogenesis of which can be attributed to acquired disorder in immune system. Polymyositis is featured as proximal muscle inflammation and extra muscular involvement. Cardiac involvements, mainly manifested as heart failure, myocarditis and arrhythmia, occur in less than 10% of patients with polymyositis [1]. Anti-Ku antibodies are not commonly positive in polymyositis [2]. However, data seems to reveal that prevalence of cardiac involvement in Connective tissue diseases (CTD) might be related to positivity of anti-Ku [3]. However, positive anti-Ku in PM patients with cardiac involvement was rarely studied. Here we report a case of anti-Ku positive polymyositis with cardiac involvement manifested with myopericarditis, which is rarely occurred and reported.

A 56-year-old menopausal female complained with intermittent chest pain for 1 day. The pain was significantly aggravated for 1 h during her shoulder massage. No medication was taken throughout the whole episode. After admission in ER, immediate ECG indicated ST-segment elevation in II/III/AVF and V2-V6 leads and elevated cardiac troponin-I, with sinus rhythm (Fig. 1). 30 min later, emergent coronary angiogram was performed, which showed no obstructive lesions in coronary arteries. Afterwards, she was admitted to cardiac care unit with a primary diagnosis of myopericarditis. Physical examination was remarkable for extremely slender habitus and transient pericardial friction rub, with no obvious crackles. Soon after admission, she presented a new-onset moderate fever (38.6 °C) and atrial fibrillation. Auxiliary examination on the admission day: CRP 55.49 mg/L, ESR 96 mm/h, WBC 18.36 × 109/L, Hb 86 g/L, PLT 192 × 10⁹/L, CK-MB 14.74 ng/mL, MYO 304.80 ng/mL, CK 602U/L, TnT-T 0.215 ng/mL, NT-proBNP 1532.0 pg/mL. Echocardiogram indicated minor pericardial effusion. Up to then, we further confirmed diagnosis of myopericarditis possibly induced by infection. Therefore, the patient was treated with oseltamivir 75 mg twice daily for 6 days, piperacillin tamzotan 4.5 g three times daily for 3 days for anti-infection; intravenous immunoglobulin (IVIg) 20 g once daily for 5 days, coenzyme Q10 and phosphocreatine for myopericarditis; diuretic therapy for heart failure; amiodarone and low molecular heparin for atrial fibrillation. 2 days after admission, ECG showed obvious recession of ST-segment, with alleviated fever and chest pain. Furthermore, the cardiac enzymes including TnT-T, CK, CK-MB gradually declined. However, 10 days after admission, the patient suffered again from a fever with the maximum temperature of 39℃ accompanied with weakness and fatigue. Without positive findings of infection, the patient was empirically treated with meropenem and levofloxacin. However, the fever recurred and the thermal spike remained still. Echocardiogram indicated no neoplasm in valves but enlargement of left ventricle (LVEDD 52 mm) and atria (31 mm * 56 mm * 44 mm) with normal ejection fraction of 54%. Cardiac MR at 3 T (Prisma, Siemens Healthcare, Erlangenm Germany) during this episode indicated diffuse swelling and gadolinium enhancement of the pericardium, as well as pericardial effusion, which was consistent with pericarditis, while elevation of global native T1- and T2-mapping value suggested myocardial edema (Fig. 2). Based on the unusual therapeutic response, we assumed that this patient was not simply myopericarditis due to infection.

Importantly, we noticed the mismatched elevation of cardiac enzymes after the episode of fever: CK elevated most (maximum 693U/L, reference range 25–200 U/L), CK-MB (maximum 39 U/L, reference range 0.1–4.94 U/L) and no elevation of TnT-T. Furthermore, we noticed that the ratio of CK/CK-MB in this patient was higher than 10, maximum 67.69. The alteration of CK/CK-MB ratio was not parallel to the alteration of TnT-T. These phenotypes of cardiac enzymes strongly indicated the damage of muscle rather than myocardium. Tracing back, the patient recalled an intermittent pain in her left shoulder-back, accompanied with weakness in upper limbs in the recent 6 months. Myositis was highly suspected based on myodynia and elevated CK. We then explored the evidence of myositis. MRI of bilateral upper arms and shoulder joints indicated degeneration and damage of left supraspinatus, left subscapularis tendon and right supraspinatus tendon, characterized by high signal in T2WI. Abnormal spontaneous activities were discovered in electromyography, indicating myopathic damage. Left arm muscle biopsy showed muscular dystrophy with lymphocytes infiltration (Fig. 3). Based on the above, the patient met the diagnostic criteria of PM according to the Bohan and Peter Criteria [4]. However, the etiology of myositis required further explorations. Negative discovery in PET-CT excluded tumors as the common cause of myositis. Finally, autoantibodies analysis (Table 1) indicated positive anti-Ku IgG (+ + +), anti-Ro-52 IgG (+) and ANA (1:3000). No proteinuria, negative findings in skins and mucosa, negative anti-SS-A, anti-SS-B, anti-Scl-70 etc. excluded myositis secondary to lupus erythematosus, sicca syndrome, systemic sclerosis (SSc), etc. Considering that the myocardium injury in CMR was adjacent to the epicardium, endomyocardial biopsy might not provide positive findings, not to mention its invasiveness. We can conclude the diagnosis of this patient was PM as well as anti-Ku syndrome with myopericarditis as cardiac involvement.

Afterwards, the patient was administrated with methylprednisolone (1 mg/kg/day) 22 days after the initial episode. Fever and fatigue were finally released. 4 days after methylprednisolone administration, CK and CK-MB was reduced to 131U/L and 11.57 U/L, respectively; NT-proBNP returned to normal. The patient was finally discharged. After discharge, the patient was followed up by both cardiologist and rheumatologist. The patient was administrated with continued glucocorticoid and mycophenolate mofetil (MMF) titrated by rheumatologist. The patient complained no upper limb weakness and fever. ESR, CRP, CK, CK-MB levels were gradually decreased and finally normal 4 months after the first glucocorticoid administration. Two months later, a follow-up CMR was performed and demonstrated diminished pericardial effusion, significantly reduced swelling and enhancement of the pericardium. The global native T1- and T2-mapping value were also decreased (global native T1 mapping: from 1300.9 to 1258.5; global native T2 mapping: from 41.7 to 39.3).

Our patient was a mid-aged menopausal woman with a chief complaint of acute chest pain, with ST-segment elevation in ECG and elevated TnT-T and CK-MB. Negative discovery in coronary angiogram excluded AMI whereas supported the diagnosis of myopericarditis. Further investigation was not conducted until the patient had an infection-unrelated fever and persisted elevated CK and CK-MB that couldn’t be explained by myopericarditis. Recalling of the pain and weakness of proximal muscle, muscle biopsy changes and muscular damage indications in electromyography met the Bohan and Peter Criteria for PM. Therefore, the patient was diagnosed of PM with myocardium and pericardium involved. Further investigation of the etiology of PM was conducted and PM secondary to tumor and other rheumatic diseases. Strong positive of anti-Ku finally attributed all of the clinical manifestation to anti-Ku syndrome. Anti-rheumatic therapy including glucocorticoid and MMF showed significant therapeutic effect in both PM and PM-related myopericarditis.