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Tumor Biology
Erschienen in: Tumor Biology 5/2013

01.10.2013 | Research Article

Chromosomal imbalances exclusively detected in invasive front area are associated with poor outcome in laryngeal carcinomas from different anatomical sites

verfasst von: Eliane Papa Ambrosio, Cássia Gisele Terrassani Silveira, Sandra Aparecida Drigo, Vivian de Souza Sacomano, Miriam Coelho Molck, Rafael Malagoli Rocha, Maria Aparecida Custódio Domingues, Fernando Augusto Soares, Luiz Paulo Kowalski, Silvia Regina Rogatto

Erschienen in: Tumor Biology | Ausgabe 5/2013

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Abstract

Laryngeal squamous cell carcinoma (LSCC) is a malignant neoplasm exhibiting aggressive phenotype, high recurrence rate, and risk of developing second primary tumors. Current evidence suggests that cells in the invasive front of carcinomas have different molecular profiles compared to those in superficial areas. This study aimed to identify candidate genes in the invasive front and superficial cells from laryngeal carcinomas that would be useful as molecular markers. Invasive front and tumor surface cells of 32 LSCC were evaluated by high-resolution comparative genomic hybridization. Both CCND1 copy number gains and cyclin D1 protein expression were evaluated to confirm gains of 11q13.3. Losses of 3q26.2-q29 and 18q23 were confirmed by loss of heterozygosity analysis. The most frequent chromosomal alterations observed only in invasive front cells involved gains of 1p, 4q, and 9p and losses of 3p, 11p, 12p, 13q, 17q, 18p, 19q, 20q, 21q, and Xp. Gains of 11q13 were detected in both components from glottis and supraglottis but only in invasive front cells from transglottic tumors. Fluorescence in situ hybridization confirmed gains of CCND1/CPE11 in a subset of cases. In supraglottic tumors, cyclin D1 positivity was associated with distant metastasis (P = 0.0018) and with decreased disease-free survival (P = 0.042). Loss of heterozygosity at 3q26.2 and 18q23 were associated with lymph node involvement (P = 0.055) and worsened prognosis, respectively. In conclusion, this study revealed regions that could be targeted in the search for molecular markers in LSCC. Cyclin D1 may be useful as a prognostic marker in supraglottic tumors.
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Metadaten
Titel
Chromosomal imbalances exclusively detected in invasive front area are associated with poor outcome in laryngeal carcinomas from different anatomical sites
verfasst von
Eliane Papa Ambrosio
Cássia Gisele Terrassani Silveira
Sandra Aparecida Drigo
Vivian de Souza Sacomano
Miriam Coelho Molck
Rafael Malagoli Rocha
Maria Aparecida Custódio Domingues
Fernando Augusto Soares
Luiz Paulo Kowalski
Silvia Regina Rogatto
Publikationsdatum
01.10.2013
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 5/2013
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-013-0866-0

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