Background
Methods
Study population
Biomarker assessment
Statistical analysis
Results
Cases: women withbreast cancer, N = 80 | Matched controls: womenwithout breast cancer, N = 156 | Nested case-controltotal, N = 236 | Unaffected cohort,N = 1729 | |
---|---|---|---|---|
N (%) | N (%) | N (%) | N (%) | |
Age at blood draw | ||||
Mean years (s.d.) | 46.2 (10.3) | 45.5 (10.9) | 45.8 (10.7) | 42.8 (13.2)b |
Ethnicity | ||||
Non-Hispanic White | 71 (88.8) | 134 (85.9) | 205 (86.9) | 1136 (65.7) |
Hispanic | 9 (11.3) | 20 (12.8) | 29 (12.3) | 414 (23.9) |
Others | 0 (0) | 2 (1.3) | 2 (0.9) | 179 (10.4) |
BMI | ||||
Mean kg/m2 (s.d.) | 24.6 (4.5) | 23.8 (4.4) | 24.1 (4.4) | 25.2 (5.6) |
Menopausal status | ||||
Pre-menopausal | 52 (65.0) | 112 (71.8) | 164 (71.9) | 1129 (67.0) |
Post-menopausal | 27 (33.8) | 37 (23.7) | 64 (28.1) | 557 (33.0) |
Smoking status | ||||
Current | 6 (7.5) | 14 (9.0) | 20 (8.5) | 153 (8.9) |
Former | 29 (36.3) | 44 (28.2) | 73 (31.1) | 513 (29.8) |
Never | 44 (55.0) | 98 (62.8) | 142 (60.4) | 1054 (61.3) |
Alcohol consumption | ||||
Current | 27 (33.8) | 58 (37.2) | 85 (36.5) | 505 (29.4) |
Former | 17 (21.3) | 24 (15.4) | 41 (17.6) | 505 (16.7) |
Never | 36 (45.0) | 71 (45.5) | 107 (45.9) | 943 (54.9) |
BOADICEA score | ||||
Mean (s.d.) | 7.94 (7.2) | 5.55 (5.0) | 6.76 (6.84) | 4.88 (6.1) |
Average risk (< 3.4%) | 19 (23.8) | 56 (35.9) | 75 (32.5) | 841 (48.6) |
Elevated risk (≥ 3.4%) | 61 (76.3) | 95 (60.9) | 156 (67.5) | 888 (51.4) |
IGF-1 level (ng/mL) | ||||
Geometric mean (geometric s.d.) | 95.0 (1.46) | 93.9 (1.45) | 94.3 (1.45) | N/A |
Median (IQR) | 99.6 (45.6) | 94.0 (45.8) | 96.4 (45.9) | N/A |
< 93.95 | 34 (42.5) | 78 (50.0) | 112 (47.5) | N/A |
Elevated (≥ 93.95)a | 46 (57.5) | 78 (50.0) | 124 (52.5) | N/A |
IGFBP-3 level (ng/mL) | ||||
Geometric mean (geometric s.d.) | 2069.3 (1.25) | 1960.3 (1.32) | 1996.6 (1.30) | N/A |
Median (IQR) | 2097 (635) | 2009 (652) | 2057 (638) | N/A |
< 2009 | 34 (42.5) | 78 (50.0) | 112 (47.5) | N/A |
Elevated (≥ 2009)a | 46 (57.5) | 78 (50.0) | 124 (52.5) | N/A |
Breast cancer relative risk | ||
---|---|---|
ORa (95% CI) | ORb (95% CI) | |
IGF-1 | ||
Log-transformed continuous IGF-1 (N = 236) | ||
1.19 (0.52, 2.70) | 0.77 (0.26, 2.31) | |
Median IGF-1 in controls (N = 236) | ||
< 93.95 ng/mL | Reference | Reference |
Elevated (≥ 93.95 ng/mL) | 1.46 (0.80, 2.71) | 1.37 (0.66, 2.85) |
ORa (95% CI) | ORc (95% CI) | |
Interaction with BOADICEA risk score (N = 231) | ||
Low IGF-1 (< 93.95), low BOADICEA risk (< 3.4%) (N = 27) | Reference | Reference |
Elevated IGF-1 (≥ 93.95), low BOADICEA risk (< 3.4%) (N = 48) | 2.49 (0.72, 8.63) | 2.76 (0.64, 11.9) |
Low IGF-1 (< 93.95), high BOADICEA risk (≥ 3.4%) (N = 81) | 3.23 (0.99, 10.59) | 3.74 (0.99, 14.2) |
Elevated IGF-1 (≥ 93.95), high BOADICEA risk (≥ 3.4%) (N = 75) | 3.82 (1.20, 12.15)* | 3.92 (1.07, 14.4)* |
RERI | − 0.90 (− 4.22, 2.41) | − 1.55 (− 5.80, 2.69) |
p value for interaction | 0.28 | 0.21 |
ORa (95% CI) | ORb (95% CI) | |
IGFBP-3 | ||
Log-transformed continuous IGFBP-3 (N = 236) | ||
2.76 (0.84, 9.07) | 4.90 (0.99, 24.1) | |
Median IGFBP-3 in controls (N = 236) | ||
< 2009 | Reference | Reference |
Elevated (≥ 2009) | 1.41 (0.79, 2.51) | 1.62 (0.81, 3.24) |
ORa (95% CI) | ORc (95% CI) | |
Interaction with BOADICEA risk score (N = 231) | ||
Low IGFBP-3 (< 2009), low BOADICEA risk (< 3.4%) (N = 28) | Reference | Reference |
Elevated IGFBP-3 (≥ 2009), low BOADICEA risk (< 3.4%) (N = 47) | 1.52 (0.48, 4.83) | 2.08 (0.55, 7.92) |
Low IGFBP-3 (< 2009), high BOADICEA risk (≥ 3.4%) (N = 81) | 2.09 (0.71, 6.13) | 2.26 (0.70, 7.25) |
Elevated IGFBP-3 (≥ 2009), high BOADICEA risk (≥ 3.4%) (N = 75) | 3.24 (1.09, 9.63)* | 3.47 (1.04, 11.6)* |
RERI | 0.63 (− 1.50, 2.77) | 0.13 (− 2.60, 2.86) |
p value for interaction | 0.97 | 0.68 |