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Erschienen in:

10.06.2020 | Epidemiology

Cisplatin given at three divided doses for three consecutive days in metastatic breast cancer: an alternative schedule for one full dose with comparable efficacy but less CINV and hypomagnesaemia

verfasst von: Jinfeng Zhang, Mingxi Lin, Yizi Jin, Linhan Gu, Ting Li, Baoying Yuan, Biyun Wang, Leiping Wang, Sheng Zhang, Jun Cao, Zhonghua Tao, Jian Zhang, Xichun Hu

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 3/2020

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Abstract

Purpose

Cisplatin, an effective medication for metastatic breast cancer (MBC), is recommended to be applied at the dose of 75 mg/m² on day 1 every 3 weeks. However, the 75 mg/m² schedule is often associated with a variety of side effects (such as vomiting and kidney toxicity), and time-consuming hydration treatment is usually needed. Divided dose (25 mg/m² on day 1–3) without hydration is an alternative. This study aimed to compare the efficacy and toxicity profiles between these two dosage regimens.

Methods

Patients with MBC treated with cisplatin-based regimens in Fudan University Shanghai Cancer Center between December 2008 and June 2019 were retrospectively analyzed. Objective response rate (ORR), progression-free survival (PFS), and toxicity profiles were analyzed.

Results

227 patients receiving a 1-day schedule and 256 patients receiving a 3-day schedule were included. Median PFS was 6.68 (5.66–7.70) months for patients in the 1-day schedule group and 6.70 (5.89–7.52) months for patients in the 3-day schedule group. There was no statistically significant difference in PFS between the two treatment groups (hazard ratio, 0.942; 95% CI 0.759 to 1.170; P = 0.589). The ORRs were comparable between the two groups. ORRs were 44.9% in 1-day schedule group and 44.5% in 3-day schedule group, respectively (P = 0.929). Compared with patients in the 3-day schedule group, patients in the 1-day schedule group experienced higher rates of chemotherapy-induced nausea and vomiting (CINV) (139 [61.2%] vs. 132 [51.6%], P = 0.033). The risk of hypomagnesaemia was also significantly higher (43.2% vs. 28.3%, P = 0.016) among patients receiving 1-day schedule (without magnesium supplementation). No other differences in adverse events were observed between the two groups.

Conclusions

Cisplatin given at three divided doses with no hydration in MBC is a less toxic (less CINV and hypomagnesaemia) schedule with comparable efficacy. Thus, it may be a good alternative for one full-dose (75 mg/m²) schedule.

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A (2015) Global cancer statistics, 2012. CA: A Cancer J Clin 65(2):87–108. https://doi.org/10.3322/caac.21262 CrossRef

Kamby C, Vejborg I, Kristensen B, Olsen LO, Mouridsen HT (1988) Metastatic pattern in recurrent breast cancer special reference to intrathoracic recurrences. Cancer 62(10):2226–2233. https://doi.org/10.1002/1097-0142(19881115)62:10<2226:aid-cncr2820621026>3.0.co;2-d CrossRefPubMed

Sun S, Tang L, Zhang J, Lv F, Wang Z, Wang L, Zhang Q, Zheng C, Qiu L, Jia Z, Lu Y, Liu G, Shao Z, Wang B, Hu X (2014) Cisplatin improves antitumor activity of weekly nab-paclitaxel in patients with metastatic breast cancer. Int J Nanomed 9:1443–1452. https://doi.org/10.2147/ijn.S58275 CrossRef

Heinemann V (2002) Gemcitabine plus cisplatin for the treatment of metastatic breast cancer. Clinical Breast Cancer 3(Suppl 1):24–29. https://doi.org/10.3816/cbc.2002.s.006 CrossRefPubMed

Zhang J, Wang Z, Hu X, Wang B, Wang L, Yang W, Liu Y, Liu G, Di G, Hu Z, Wu J, Shao Z (2015) Cisplatin and gemcitabine as the first line therapy in metastatic triple negative breast cancer. Int J Cancer 136(1):204–211. https://doi.org/10.1002/ijc.28966 CrossRefPubMed

Reis-Filho JS, Tutt AN (2008) Triple negative tumours: a critical review. Histopathology 52(1):108–118. https://doi.org/10.1111/j.1365-2559.2007.02889.x CrossRefPubMed

Koshy N, Quispe D, Shi R, Mansour R, Burton GV (2010) Cisplatin-gemcitabine therapy in metastatic breast cancer: improved outcome in triple negative breast cancer patients compared to non-triple negative patients. Breast 19(3):246–248. https://doi.org/10.1016/j.breast.2010.02.003 CrossRefPubMed

Jiao Q, Wu A, Shao G, Peng H, Wang M, Ji S, Liu P, Zhang J (2014) The latest progress in research on triple negative breast cancer (TNBC): risk factors, possible therapeutic targets and prognostic markers. J Thorac Dis 6(9):1329–1335. https://doi.org/10.3978/j.issn.2072-1439.2014.08.13 CrossRefPubMedPubMedCentral

Zhang J, Fan M, Xie J, Wang Z, Wang B, Zhang S, Wang L, Cao J, Tao Z, Li T, Hu X (2015) Chemotherapy of metastatic triple negative breast cancer: experience of using platinum-based chemotherapy. Oncotarget 6(40):43135–43143. https://doi.org/10.18632/oncotarget.5654 CrossRefPubMedPubMedCentral

10.

Hu XC, Zhang J, Xu BH, Cai L, Ragaz J, Wang ZH, Wang BY, Teng YE, Tong ZS, Pan YY, Yin YM, Wu CP, Jiang ZF, Wang XJ, Lou GY, Liu DG, Feng JF, Luo JF, Sun K, Gu YJ, Wu J, Shao ZM (2015) Cisplatin plus gemcitabine versus paclitaxel plus gemcitabine as first-line therapy for metastatic triple-negative breast cancer (CBCSG006): a randomised, open-label, multicentre, phase 3 trial. Lancet Oncol 16(4):436–446. https://doi.org/10.1016/s1470-2045(15)70064-1 CrossRefPubMed

11.

Zhang J, Lin Y, Sun XJ, Wang BY, Wang ZH, Luo JF, Wang LP, Zhang S, Cao J, Tao ZH, Wu J, Shao ZM, Yang WT, Hu XC (2018) Biomarker assessment of the CBCSG006 trial: a randomized phase III trial of cisplatin plus gemcitabine compared with paclitaxel plus gemcitabine as first-line therapy for patients with metastatic triple-negative breast cancer. Ann Oncology: Off J Eur Soc Med Oncol 29(8):1741–1747. https://doi.org/10.1093/annonc/mdy209 CrossRef

12.

Pabla N, Dong Z (2008) Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int 73(9):994–1007. https://doi.org/10.1038/sj.ki.5002786 CrossRefPubMed

13.

Eastman A (1987) The formation, isolation and characterization of DNA adducts produced by anticancer platinum complexes. Pharmacol Ther 34(2):155–166. https://doi.org/10.1016/0163-7258(87)90009-x CrossRefPubMed

14.

Siddik ZH (2003) Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 22(47):7265–7279. https://doi.org/10.1038/sj.onc.1206933 CrossRefPubMed

15.

Cohen SM, Lippard SJ (2001) Cisplatin: from DNA damage to cancer chemotherapy. Prog Nucleic Acid Res Mol Biol 67:93–130. https://doi.org/10.1016/s0079-6603(01)67026-0 CrossRefPubMed

16.

Hastak K, Alli E, Ford JM (2010) Synergistic chemosensitivity of triple-negative breast cancer cell lines to poly(ADP-Ribose) polymerase inhibition, gemcitabine, and cisplatin. Can Res 70(20):7970–7980. https://doi.org/10.1158/0008-5472.Can-09-4521 CrossRef

17.

Murphy CG, Seidman AD (2009) Evolving approaches to metastatic breast cancer previously treated with anthracyclines and taxanes. Clinical Breast Cancer 9(Suppl 2):S58–65. https://doi.org/10.3816/CBC.2009.s.006 CrossRefPubMed

18.

Kim JS, Park IH, Lee KS, Ro J (2014) Outcomes of palliative weekly low-dose gemcitabine-Cisplatin chemotherapy in anthracycline- and taxane- pretreated metastatic breast cancer patients. J Breast Cancer 17(4):339–343. https://doi.org/10.4048/jbc.2014.17.4.339 CrossRefPubMedPubMedCentral

19.

Erten C, Demir L, Somali I, Alacacioglu A, Kucukzeybek Y, Akyol M, Can A, Dirican A, Bayoglu V, Tarhan MO (2013) Cisplatin plus gemcitabine for treatment of breast cancer patients with brain metastases; a preferential option for triple negative patients? Asian Pac J Cancer Prev: APJCP 14(6):3711–3717. https://doi.org/10.7314/apjcp.2013.14.6.3711 CrossRefPubMed

20.

Bodnar L, Wcislo G, Gasowska-Bodnar A, Synowiec A, Szarlej-Wcislo K, Szczylik C (2008) Renal protection with magnesium subcarbonate and magnesium sulphate in patients with epithelial ovarian cancer after cisplatin and paclitaxel chemotherapy: a randomised phase II study. Eur J Cancer 44(17):2608–2614. https://doi.org/10.1016/j.ejca.2008.08.005 CrossRefPubMed

21.

Mehta RL, Awdishu L, Davenport A, Murray PT, Macedo E, Cerda J, Chakaravarthi R, Holden AL, Goldstein SL (2015) Phenotype standardization for drug-induced kidney disease. Kidney Int 88(2):226–234. https://doi.org/10.1038/ki.2015.115 CrossRefPubMedPubMedCentral

22.

Oh GS, Kim HJ, Shen A, Lee SB, Khadka D, Pandit A, So HS (2014) Cisplatin-induced kidney dysfunction and perspectives on improving treatment strategies. Electrolyte Blood Press 12(2):55–65. https://doi.org/10.5049/ebp.2014.12.2.55 CrossRefPubMedPubMedCentral

23.

Daugaard G, Abildgaard U, Holstein-Rathlou NH, Bruunshuus I, Bucher D, Leyssac PP (1988) Renal tubular function in patients treated with high-dose cisplatin. Clin Pharmacol Ther 44(2):164–172. https://doi.org/10.1038/clpt.1988.132 CrossRefPubMed

24.

Oka T, Kimura T, Suzumura T, Yoshimoto N, Nakai T, Yamamoto N, Matsuura K, Mitsuoka S, Yoshimura N, Kudoh S, Hirata K (2014) Magnesium supplementation and high volume hydration reduce the renal toxicity caused by cisplatin-based chemotherapy in patients with lung cancer: a toxicity study. BMC Pharmacol Toxicol 15:70. https://doi.org/10.1186/2050-6511-15-70 CrossRefPubMedPubMedCentral

25.

Lajer H, Daugaard G (1999) Cisplatin and hypomagnesemia. Cancer Treat Rev 25(1):47–58. https://doi.org/10.1053/ctrv.1999.0097 CrossRefPubMed

26.

Hodgkinson E, Neville-Webbe HL, Coleman RE (2006) Magnesium depletion in patients receiving cisplatin-based chemotherapy. Clinical Oncol 18(9):710–718. https://doi.org/10.1016/j.clon.2006.06.011 CrossRef

27.

Seo JH, Oh SC, Choi CW, Kim BS, Shin SW, Kim YH, Kim JS, Kim AR, Lee JB, Koo BH (2007) Phase II study of a gemcitabine and cisplatin combination regimen in taxane resistant metastatic breast cancer. Cancer Chemother Pharmacol 59(2):269–274. https://doi.org/10.1007/s00280-006-0266-x CrossRefPubMed

28.

Kim JH, Oh SY, Kwon HC, Lee S, Kim SH, Kim DC, Lee JH, Lee HS, Cho SH, Kim HJ (2008) Phase II study of gemcitabine plus cisplatin in patients with anthracycline- and taxane- pretreated metastatic breast cancer. Cancer Res Treat: Off J Korean Cancer Assoc 40(3):101–105. https://doi.org/10.4143/crt.2008.40.3.101 CrossRef

29.

Brito LG, de Andrade JM, Lins-Almeida T, Zola FE, Pinheiro MN, Marana HR, Tiezzi DG, Peria FM (2012) Safety and efficacy of gemcitabine plus cisplatin combination in pretreated metastatic breast cancer patients. Med Oncol 29(1):33–38. https://doi.org/10.1007/s12032-010-9793-8 CrossRefPubMed

30.

Chen Y, Han F, Cao LH, Li C, Wang JW, Li Q, Zheng W, Guo ZX, Li AH, Zhou JH (2015) Dose-response relationship in cisplatin-treated breast cancer xenografts monitored with dynamic contrast-enhanced ultrasound. BMC Cancer 15:136. https://doi.org/10.1186/s12885-015-1170-8 CrossRefPubMedPubMedCentral

31.

Kim JH, Lee DH, Shin HC, Kwon JH, Jung JY, Kim HJ, Song HH, Lee KS, Zang DY, Ahn JS, Park YL, Lee JA (2006) A phase II study with gemcitabine and split-dose cisplatin in patients with advanced non-small cell lung cancer. Lung Cancer 54(1):57–62. https://doi.org/10.1016/j.lungcan.2006.06.013 CrossRefPubMed

32.

Funai K, Takamochi K, Itaya T, Mochizuki T, Nakamura T, Toyoda F, Yong-Il K, Sasaki K, Momiki S, Takahashi T, Neyatani H, Suzuki K (2010) Feasibility study of adjuvant chemotherapy with gemcitabine and split-dose cisplatin for completely resected non-small-cell lung cancer. Lung Cancer 68(1):78–83. https://doi.org/10.1016/j.lungcan.2009.05.018 CrossRefPubMed

33.

Miller RP, Tadagavadi RK, Ramesh G, Reeves WB (2010) Mechanisms of cisplatin nephrotoxicity. Toxins 2(11):2490–2518. https://doi.org/10.3390/toxins2112490 CrossRefPubMedPubMedCentral

34.

Crona DJ, Faso A, Nishijima TF, McGraw KA, Galsky MD, Milowsky MI (2017) A systematic review of strategies to prevent cisplatin-induced nephrotoxicity. Oncologist 22(5):609–619. https://doi.org/10.1634/theoncologist.2016-0319 CrossRefPubMedPubMedCentral

35.

Aalbersberg EA, Rossi MM, de Wit-van der Veen LJ, Walraven I, van den Heuvel MM, Sonke JJ, Belderbos JS, Vogel WV (2019) Pre-hydration in cisplatin-based CCRT: effects on tumour concentrations and treatment outcome. Radiother Oncol: J Eur Soc Therap Radiol Oncol 134:30–36. https://doi.org/10.1016/j.radonc.2019.01.015 CrossRef

36.

Biedermann B, Landmann C, Kann R, Passweg J, Soler M, Lohri A, Rochlitz C, Herrmann R, Pless M (2000) Combined chemoradiotherapy with daily low-dose cisplatin in locally advanced inoperable non-small cell lung cancer. Radiother Oncol: J Eur Soc Therap Radiol Oncol 56(2):169–173. https://doi.org/10.1016/s0167-8140(00)00203-6 CrossRef

37.

Hazuka MB, Crowley JJ, Bunn PA Jr, O'Rourke M, Braun TJ, Livingston RB (1994) Daily low-dose cisplatin plus concurrent high-dose thoracic irradiation in locally advanced unresectable non-small-cell lung cancer: results of a phase II Southwest Oncology Group study. J Clin Oncol: Off J Am Soc Clin Oncol 12(9):1814–1820. https://doi.org/10.1200/jco.1994.12.9.1814 CrossRef

38.

Semb S, Helgstrand F, Hjorne F, Bytzer P (2017) Persistent severe hypomagnesemia caused by proton pump inhibitor resolved after laparoscopic fundoplication. World J Gastroenterol 23(37):6907–6910. https://doi.org/10.3748/wjg.v23.i37.6907 CrossRefPubMedPubMedCentral

39.

Besic N, Zagar S, Pilko G, Peric B, Hocevar MJR (2008) Influence of magnesium sulphate infusion before total thyroidectomy on transient hypocalcemia—a randomised study. Radiol Oncol 42(3):143–150CrossRef

40.

Jiang DM, Dennis K, Steinmetz A, Clemons M, Asmis TR, Goodwin RA, Vickers MM (2016) Management of epidermal growth factor receptor inhibitor-induced hypomagnesemia: a systematic review. Clin Colorectal Cancer 15(3):e117–123. https://doi.org/10.1016/j.clcc.2016.02.011 CrossRefPubMed

41.

Egger SJ, Willson ML, Morgan J, Walker HS, Carrick S, Ghersi D, Wilcken N. (2017). Platinum-containing regimens for metastatic breast cancer. Cochrane Database Sys Rev, 6:Cd003374. doi:10.1002/14651858.CD003374.pub

Titel: Cisplatin given at three divided doses for three consecutive days in metastatic breast cancer: an alternative schedule for one full dose with comparable efficacy but less CINV and hypomagnesaemia
verfasst von: Jinfeng Zhang
Mingxi Lin
Yizi Jin
Linhan Gu
Ting Li
Baoying Yuan
Biyun Wang
Leiping Wang
Sheng Zhang
Jun Cao
Zhonghua Tao
Jian Zhang
Xichun Hu
Publikationsdatum: 10.06.2020
Verlag: Springer US
Erschienen in: Breast Cancer Research and Treatment / Ausgabe 3/2020
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-020-05730-2

Springer Medizin

Cisplatin given at three divided doses for three consecutive days in metastatic breast cancer: an alternative schedule for one full dose with comparable efficacy but less CINV and hypomagnesaemia