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Breast Cancer Research and Treatment

Breast Cancer Research and Treatment OnlineFirst articles

22.05.2018 | Clinical trial

Identification of risk factors for toxicity in patients with hormone receptor-positive advanced breast cancer treated with bevacizumab plus letrozole: a CALGB 40503 (alliance) correlative study

Chronological age alone tells relatively little about an adult’s overall functional age. Therefore, the use of pretreatment assessments consisting of validated measures that can capture domains such as functional status, comorbid medical …

19.05.2018 | Clinical trial

Intratumoral heterogeneity on dedicated breast positron emission tomography predicts malignancy grade of breast cancer

18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is useful for staging in various malignancies [ 1 – 5 ]. FDG-PET/CT can also be used to evaluate the effects of chemotherapy based on its ability to assess …

17.05.2018 | Epidemiology

Age at first full-term birth and breast cancer risk in BRCA1 and BRCA2 mutation carriers

In the general population, an early age at first full-term birth confers a significant and sustained reduction in the risk of developing breast cancer [ 1 , 2 ]. Pregnancy-induced changes (cellular, molecular, and physiologic) in the mammary tissue …

17.05.2018 | Editorial Open Access

Reproducibility and predictive value of scoring stromal tumour infiltrating lymphocytes in triple-negative breast cancer: a multi-institutional study

The role of the immune system in the pathogenesis and clinical course of cancer is well established [ 1 , 2 ] and has received renewed attention with the success of immunotherapies for several solid organ cancers such as melanoma and lung cancer.

16.05.2018 | Preclinical study

Metastatic Breast Cancer Collateral Damage Project (MBCCD): Scale development and preliminary results of the Survey of Health, Impact, Needs, and Experiences (SHINE)

In 2018, an estimated 268,670 women and men will be diagnosed with breast cancer and an estimated 41,400 will die [ 1 ], with the majority of deaths resulting from metastatic breast cancer (MBC). Survival rates for de novo MBC have increased …

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