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Breast Cancer Research and Treatment

Breast Cancer Research and Treatment OnlineFirst articles

17.09.2018 | Epidemiology

Prognosis in patients diagnosed with loco-regional failure of breast cancer: 34 years longitudinal data from the Stockholm–Gotland cancer registry

As a result of advances in local [ 1 – 3 ] and adjuvant systemic treatment since the early 1980s [ 4 – 8 ], breast cancer recurrence and mortality rates have decreased steadily and 5 year survival estimates currently exceed 90% in some Western …

17.09.2018 | Epidemiology

Young age at diagnosis is associated with worse prognosis in the Luminal A breast cancer subtype: a retrospective institutional cohort study

Breast cancer (BCA) is a common and heterogeneous disease. In 2017, there were 268,670 new cases of invasive breast cancer and 41,400 breast cancer deaths among US women [ 1 ]. Sorlie and Perou first classified breast carcinomas based on variations …

17.09.2018 | Preclinical study Open Access

Micro-computed tomography enables rapid surgical margin assessment during breast conserving surgery (BCS): correlation of whole BCS micro-CT readings to final histopathology

Breast conserving surgery (BCS) in combination with radiotherapy has become standard-of-care for treatment of early stage breast cancer, offering equivalent survival to full mastectomy, but with a far less extensive surgical procedure [ 1 ].

15.09.2018 | Brief Report

Effectiveness and tolerability of neoadjuvant pertuzumab-containing regimens for HER2-positive localized breast cancer

Human epidermal growth factor receptor-2 positive (HER2+) breast cancer is defined by amplification of the HER2/neu oncogene and represents an aggressive subtype of breast cancer [ 1 ]. Approximately 20% of breast cancers overexpress the HER2 …

15.09.2018 | Preclinical study

CCN6 regulates IGF2BP2 and HMGA2 signaling in metaplastic carcinomas of the breast

Metaplastic breast carcinoma is a rare form of breast cancer that exhibits transformation of part or all of its glandular carcinomatous component into a non-glandular, or metaplastic, component [ 1 , 2 ]. The metaplastic component(s) is most …

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