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11.08.2018 | Original Article

Clinical and Molecular Characterization of Surgically Treated Oropharynx Squamous Cell Carcinoma Samples

verfasst von: Ana Carolina de Carvalho, Matias Eliseo Melendez, Cristina da Silva Sabato, Edenir Inez Palmero, Lidia Maria Rebolho Batista Arantes, Cristovam Scapulatempo Neto, André Lopes Carvalho

Erschienen in: Pathology & Oncology Research | Ausgabe 3/2019

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Abstract

A better understanding of the clinical and molecular features of oropharyngeal squamous cell carcinomas (OPSCC) may help in the development of strategies for a better patient management, improving survival rates. This retrospective study conducted a clinical and molecular characterization of surgically treated OPSCC samples. Paraffin-embedded samples from a series of cases were screened for high-risk (HR) human papillomavirus (HPV) infection, methylation of a 5-gene panel, p53 expression, and TP53 mutation. The study was conducted at Barretos Cancer Hospital. Twenty-five surgically treated OPSCC with available tissue were included in the study. Samples were classified according to HPV status and molecular features and some of these characteristics were associated to clinical data. Twenty percent of the cases were HR-HPV positive and 62.5% presented TP53 mutations. DAPK hypermethylation was associated with HPV status (p = 0.023), while methylated CCNA1 was inversely related to TP53 mutations in primary tumors (p = 0.042) and associated with a better disease-free survival (22.3% vs. 100.0%; p = 0.028) and overall survival (8.0% vs. 100.0%; p = 0.012). The results show differences regarding molecular and clinical characteristics in the oropharynx cases identified that should be validated in more cases to confirm whether these differences are able to classify patients according to outcome and help in a more thorough patient management.

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Titel: Clinical and Molecular Characterization of Surgically Treated Oropharynx Squamous Cell Carcinoma Samples
verfasst von: Ana Carolina de Carvalho
Matias Eliseo Melendez
Cristina da Silva Sabato
Edenir Inez Palmero
Lidia Maria Rebolho Batista Arantes
Cristovam Scapulatempo Neto
André Lopes Carvalho
Publikationsdatum: 11.08.2018
Verlag: Springer Netherlands
Erschienen in: Pathology & Oncology Research / Ausgabe 3/2019
Print ISSN: 1219-4956
Elektronische ISSN: 1532-2807
DOI: https://doi.org/10.1007/s12253-018-0462-0

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Clinical and Molecular Characterization of Surgically Treated Oropharynx Squamous Cell Carcinoma Samples

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