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Clinical and Translational Oncology

Clinical and Translational Oncology OnlineFirst articles

14.01.2019 | Review Article

Time for radioimmunotherapy: an overview to bring improvements in clinical practice

Harnessing the patient’s own immune system against an established cancer has proven to be a successful strategy. Within the last years, several antibodies blocking critical “checkpoints” that control the activation of T cells, the immune cells …

12.01.2019 | Review Article

The role of immunotherapy in small cell lung cancer

Despite decades of research, prognosis for SCLC patients remains poor, and treatment options limited. SCLC is an immunogenic tumor with high somatic mutation rates due to tobacco exposure resulting in potential neo-antigens, the presence of …

12.01.2019 | Research Article

Clinical significance of serum EGFR gene mutation and serum tumor markers in predicting tyrosine kinase inhibitor efficacy in lung adenocarcinoma

Lung cancer is currently one of the most serious diseases endangering the health of human beings [ 1 ]. In recent years, non-small cell lung cancer (NSCLC) accounts for about 75–85% of the total number of lung cancers [ 2 ]. Lung adenocarcinoma is …

12.01.2019 | Research Article

Identification a novel set of 6 differential expressed genes in prostate cancer that can potentially predict biochemical recurrence after curative surgery

Approximately, 23–34% prostate cancer patients will undergo post-operative disease relapse, initially with increased serum prostate specific antigen (PSA) value. Some patients with BCR will progress to local recurrence and distant metastasis.

10.01.2019 | Research Article

A comparative assessment of the effects of integrin inhibitor cilengitide on primary culture of head and neck squamous cell carcinoma (HNSCC) and HNSCC cell lines

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignant lesion worldwide, with the highest incidence rate, and accounts for 90% of all oral cancers [ 1 ]. Current curative treatment includes surgery, irradiation alone and …

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Clinical and Translational Oncology is an international journal devoted to fostering interaction between experimental and clinical oncology. It covers all aspects of research on cancer, from the more basic discoveries dealing with both cell and molecular biology of tumour cells, to the most advanced clinical assays of conventional and new drugs. In addition, the journal has a strong commitment to facilitating the transfer of knowledge from the basic laboratory to the clinical practice, with the publication of educational series devoted to closing the gap between molecular and clinical oncologists. Molecular biology of tumours, identification of biomarkers for cancer diagnosis, prognosis or prediction of treatment response, identification of new targets for cancer therapy, as well as development of new technologies for research and treatment of cancer are the major themes covered by both the educational series and research articles. A broad spectrum of subjects, including the molecular and cellular bases of disease, aetiology, pathophysiology, pathology, epidemiology, clinical features, and the diagnosis, prognosis and treatment of cancer, will be considered for publication.

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