Background
Methods
Study selection
Mechanical prophylaxis | TKA P3 N = 594 | THA P3 N = 503 | HFS P3 N = 73 | |
---|---|---|---|---|
GCS | IPC | |||
o | x | 129 | 136 | 39 |
o | o | 238 | 274 | 15 |
x | o | 123 | 92 | 10 |
x | x | 104 | 1 | 9 |
Study design and site selection
Statistical analysis
Results
Demographic and other baseline characteristics | No mechanical prophylaxis | GCS alone | ||
---|---|---|---|---|
N = 100 |
N = 101 | |||
Edoxaban | Enoxaparin | Edoxaban | Enoxaparin | |
N = 52 |
N = 48 |
N = 53 |
N = 48 | |
Sex, n (%) | ||||
Male | 11 (21.2) | 9 (18.8) | 8 (15.1) | 9 (18.8) |
Female | 41 (78.8) | 39 (81.3) | 45 (84.9) | 39 (81.3) |
Age, (y) | ||||
Mean ± SD | 70.9 ± 7.9 | 71.7 ± 7.8 | 73.5 ± 6.1 | 73.2 ± 7.0 |
Weight, (kg) | ||||
Mean ± SD | 63.2 ± 10.2 | 64.3 ± 11.9 | 56.8 ± 10.2 | 60.3 ± 10.1 |
CLcr, (mL/min) | ||||
Mean ± SD | 78.3 ± 24.6 | 76.2 ± 26.5 | 71.1 ± 20.1 | 74.9 ± 20.0 |
Duration of surgery, (h:min) | ||||
Mean ± SD | 2:03 ± 0:44 | 1:59 ± 0:35 | 1:42 ± 0:26 | 1:45 ± 0:24 |
Tourniquet use during surgery, n (%) | 50 (96.2) | 46 (95.8) | 42 (79.2) | 38 (79.2) |
Method of anesthesia, n (%) | ||||
General anesthesia | 43 (82.7) | 35 (72.9) | 24 (45.3) | 20 (41.7) |
Epidural anesthesia | 8 (15.4) | 7 (14.6) | 17 (32.1) | 14 (29.2) |
Lumbar anesthesia | 24 (46.2) | 24 (50.0) | 38 (71.7) | 34 (70.8) |
Duration from the end of surgery to the start of anticoagulation, (h:min) | ||||
Mean ± SD | 20:31 ± 2:39 | 30:41 ± 3:26 | 19:43 ± 2:59 | 27:08 ± 2:30 |
Duration from surgery to ambulation (days) | ||||
Mean ± SD | 2.2 ± 0.7 | 2.4 ± 0.8 | 3.6 ± 1.4 | 3.8 ± 2.1 |
Duration of treatment (days) | ||||
Mean ± SD | 12.1 ± 1.6 | 11.6 ± 2.6 | 12.4 ± 1.6 | 12.4 ± 1.7 |
Duration of GCS use (days) | ||||
Mean ± SD | - | - | 9.5 ± 2.7 | 9.6 ± 2.7 |
Edoxaban | Enoxaparin | Total | |
---|---|---|---|
N = 105 |
N = 96 |
N = 201 | |
No mechanical prophylaxis | 5.8 % (3/52) | 20.8 % (10/48) | 13.0 % (13/100) |
Mechanical prophylaxis with GCS alone | 3.8 % (2/53) | 8.4 % (4/48) | 6.0 % (6/101) |
Chi-square test |
p = 0.6312 |
p = 0.0827 |
p = 0.0872 |
Difference between with and without GCS treatment groups | –2.0 | –12.5 | –7.1 |
95 % CI of the difference shown by the score test | −12.2, 7.8 | −26.8, 1.9 | −15.7, 1.2 |