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Clinical Drug Investigation

Ausgabe 7/2013

Inhalt (8 Artikel)

Review Article

Current Topics in Opioid Therapy for Pain Management: Addressing the Problem of Abuse

Frank E. Casty, Matthew S. Wieman, Neil Shusterman

Original Research Article

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Repeat Inhaled Doses of Umeclidinium in Healthy Subjects: Two Randomized Studies

Anthony Cahn, Ruth Tal-Singer, Isabelle J. Pouliquen, Rashmi Mehta, Andrew Preece, Kelly Hardes, Glenn Crater, Amanda Deans

Original Research Article

The Effect of Moderate Hepatic Impairment on the Pharmacokinetics of Ipragliflozin, a Novel Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitor

Wenhui Zhang, Walter J. J. Krauwinkel, James Keirns, Robert W. Townsend, Kenneth C. Lasseter, Lisa Plumb, Takeshi Kadokura, Fumihiko Ushigome, Ronald Smulders

Open Access Original Research Article

Treatment of Morton Neuroma with Botulinum Toxin A: A Pilot Study

José M. Climent, Francisco Mondéjar-Gómez, Carmen Rodríguez-Ruiz, Ismael Díaz-Llopis, Diego Gómez-Gallego, Patricia Martín-Medina

Original Research Article

A Comparison of the Steady-State Pharmacokinetic and Pharmacodynamic Profiles of 100 and 200 U/mL Formulations of Ultra-Long-Acting Insulin Degludec

Stefan Korsatko, Sigrid Deller, Gerd Koehler, Julia K. Mader, Katharina Neubauer, Charlotte L. Adrian, Henrik Thomsen, Hanne Haahr, Thomas R. Pieber

Original Research Article

Developmental Changes in Morphine Clearance Across the Entire Paediatric Age Range are Best Described by a Bodyweight-Dependent Exponent Model

Chenguang Wang, Senthilkumar Sadhavisvam, Elke H. J. Krekels, Albert Dahan, Dick Tibboel, Meindert Danhof, Alexander A. Vinks, Catherijne A. J. Knibbe