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26.01.2017 | Original Article | Ausgabe 7/2017

European Journal of Nuclear Medicine and Molecular Imaging 7/2017

Clinical evaluation of TOF versus non-TOF on PET artifacts in simultaneous PET/MR: a dual centre experience

Zeitschrift:
European Journal of Nuclear Medicine and Molecular Imaging > Ausgabe 7/2017
Autoren:
Edwin E. G. W. ter Voert, Patrick Veit-Haibach, Sangtae Ahn, Florian Wiesinger, M. Mehdi Khalighi, Craig S. Levin, Andrei H. Iagaru, Greg Zaharchuk, Martin Huellner, Gaspar Delso
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s00259-017-3619-2) contains supplementary material, which is available to authorized users.

Abstract

Purpose

Our objective was to determine clinically the value of time-of-flight (TOF) information in reducing PET artifacts and improving PET image quality and accuracy in simultaneous TOF PET/MR scanning.

Methods

A total 65 patients who underwent a comparative scan in a simultaneous TOF PET/MR scanner were included. TOF and non-TOF PET images were reconstructed, clinically examined, compared and scored. PET imaging artifacts were categorized as large or small implant-related artifacts, as dental implant-related artifacts, and as implant-unrelated artifacts. Differences in image quality, especially those related to (implant) artifacts, were assessed using a scale ranging from 0 (no artifact) to 4 (severe artifact).

Results

A total of 87 image artifacts were found and evaluated. Four patients had large and eight patients small implant-related artifacts, 27 patients had dental implants/fillings, and 48 patients had implant-unrelated artifacts. The average score was 1.14 ± 0.82 for non-TOF PET images and 0.53 ± 0.66 for TOF images (p < 0.01) indicating that artifacts were less noticeable when TOF information was included.

Conclusion

Our study indicates that PET image artifacts are significantly mitigated with integration of TOF information in simultaneous PET/MR. The impact is predominantly seen in patients with significant artifacts due to metal implants.

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Zusatzmaterial
ESM 1 (DOCX 24.2 kb)
259_2017_3619_MOESM1_ESM.docx
ESM 2 (DOCX 2.25 mb)
259_2017_3619_MOESM2_ESM.docx
ESM 3 (DOCX 2.45 mb)
259_2017_3619_MOESM3_ESM.docx
Literatur
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