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Current Hypertension Reports
Erschienen in: Current Hypertension Reports 11/2015

01.11.2015 | Pathogenesis of Hypertension (W Elliott, Section Editor)

Clinical Significance of Endothelial Dysfunction in Essential Hypertension

verfasst von: Eugenia Gkaliagkousi, Eleni Gavriilaki, Areti Triantafyllou, Stella Douma

Erschienen in: Current Hypertension Reports | Ausgabe 11/2015

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Abstract

The endothelium is recognized as a major determinant of vascular physiology and pathophysiology. Over the last few decades, a plethora of studies have implicated endothelial dysfunction in the progression of atherosclerosis and the subclinical target organ damage observed in essential hypertension. However, the clinical significance of diagnosing endothelial dysfunction in patients with essential hypertension remains under investigation. Although a number of vascular and non-vascular markers of endothelial dysfunction have been proposed, there is an ongoing quest for a marker in the clinical setting that is optimal, inexpensive, and reproducible. In addition, endothelial dysfunction emerges as a promising therapeutic target of agents that are readily available in clinical practice. In this context, a better understanding of its role in essential hypertension becomes of great importance. Here, we aim to investigate the clinical significance of endothelial dysfunction in essential hypertension by accumulating novel data on (a) early diagnosis using robust markers with prognostic value in cardiovascular risk prediction, (b) the association of endothelial dysfunction with subclinical vascular organ damage, and (c) potential therapeutic targets.
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Metadaten
Titel
Clinical Significance of Endothelial Dysfunction in Essential Hypertension
verfasst von
Eugenia Gkaliagkousi
Eleni Gavriilaki
Areti Triantafyllou
Stella Douma
Publikationsdatum
01.11.2015
Verlag
Springer US
Erschienen in
Current Hypertension Reports / Ausgabe 11/2015
Print ISSN: 1522-6417
Elektronische ISSN: 1534-3111
DOI
https://doi.org/10.1007/s11906-015-0596-3

Weitere Artikel der Ausgabe 11/2015

Current Hypertension Reports 11/2015 Zur Ausgabe

Hypertension and the Kidney (RM Carey, Section Editor)

Current Approaches to Quantifying Tonic and Reflex Autonomic Outflows Controlling Cardiovascular Function in Humans and Experimental Animals

Hypertension and the Brain (S Stocker, Section Editor)

Exercise for Hypertension: A Prescription Update Integrating Existing Recommendations with Emerging Research

Prevention of Hypertension: Public Health Challenges (P Muntner, Section Editor)

The Utility of Ambulatory Blood Pressure Monitoring for Diagnosing White Coat Hypertension in Older Adults

Prevention of Hypertension: Public Health Challenges (P Muntner, Section Editor)

Mechanisms Influencing Circadian Blood Pressure Patterns Among Individuals with HIV

Preeclampsia (V Garovic, Section Editor)

Preeclampsia: Syndrome or Disease?

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