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Current Cardiovascular Imaging Reports

Erschienen in:

01.09.2017 | Intravascular Imaging (IK Jang, Section Editor)

Clinical Utility of Virtual Histology Intravascular Ultrasound

verfasst von: Akiko Maehara, Gary S. Mintz

Erschienen in: Current Cardiovascular Imaging Reports | Ausgabe 9/2017

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Abstract

Purpose of Review

Tissue characterization using imaging is important to understand the pathophysiology of atherosclerosis and subsequent outcomes. In this review, the clinical utility of virtual histology intravascular ultrasound (VH-IVUS), which provides a quantitative and more objective evaluation of tissue characterization compared with grayscale IVUS, will be summarized.

Recent Findings

Patient clinical characteristics, including coronary risk factors and medications, are associated with lesion morphology, especially plaque vulnerability. Different levels of vulnerability cause different clinical presentations and associated long-term outcomes. For example, in the first natural history study (Providing Regional Observations to Study Predictors of Events in the Coronary Tree [PROSPECT]), we showed that large plaque burden, small lumen area, and presence of thin-cap fibroatheroma were associated with subsequent outcomes at 3-year follow-up.

Summary

VH-IVUS has contributed significantly to our understanding of atherosclerosis.

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•• Stone GW, Maehara A, Lansky AJ, et al. A prospective natural-history study of coronary atherosclerosis. N Engl J Med. 2011;364:226–35. This is the first prospective natural history of atherosclerosis study to show the importance of plaque burden, lumen narrowing, and thin-cap fibroatheroma by VH-IVUS to predict future events. CrossRefPubMed

• Maehara A, Cristea E, Mintz GS, et al. Definitions and methodology for the grayscale and radiofrequency intravascular ultrasound and coronary angiographic analyses. JACC Cardiovasc Imaging. 2012;5:S1–9. This describes (in detail) the definitions and methodology of VH-IVUS. CrossRefPubMed

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Dong L, Mintz GS, Witzenbichler B, et al. Comparison of plaque characteristics in narrowings with ST-elevation myocardial infraction (STEMI), non-STEMI/unstable angina pectoris and stable coronary artery disease (from the ADAPT-DES IVUS substudy). Am J Cardiol. 2015;115:860–6.CrossRefPubMed

10.

Wang L, Mintz GS, Witzenbichler B, et al. Differences in underlying culprit lesion morphology between men and women: an IVUS analysis from the ADAPT-DES study. JACC Cardiovasc Imaging. 2016;9:498–9.CrossRefPubMed

11.

Qian J, Maehara A, Mintz GS, et al. Impact of gender and age on in vivo virtual histology-intravascular ultrasound imaging plaque characterization (from the global virtual histology intravascular ultrasound [VH-IVUS] registry). Am J Cardiol. 2009;103:1210–4.CrossRefPubMed

12.

Kadohira T, Mintz GS, Souza CF, et al. Impact of chronic statin therapy on clinical presentation and underlying lesion morphology in patients undergoing percutaneous intervention: an ADAPT-DES IVUS substudy. Coron Artery Dis. 2017;28:218–24.CrossRefPubMed

13.

Zheng B, Mintz GS, McPherson JA, et al. Predictors of plaque rupture within nonculprit fibroatheromas in patients with acute coronary syndromes. JACC Cardiovasc Imaging. 2015;8:1180–7.CrossRefPubMed

14.

Baber U, Stone GW, Weisz G, et al. Coronary plaque composition, morphology, and outcomes in patients with and without chronic kidney disease presenting with acute coronary syndromes. JACC Cardiovasc Imaging. 2012;5:S53–61.CrossRefPubMed

15.

Chin CY, Mintz GS, Saito S, et al. Relation between renal function and coronary plaque morphology (from the assessment of dual antiplatelet therapy with drug-eluting stents virtual histology-intravascular ultrasound substudy). Am J Cardiol. 2017;119:217–24.CrossRefPubMed

16.

Kang SJ, Mintz GS, Weisz G, et al. Age-related effects of smoking on coronary artery disease assessed by gray scale and virtual histology intravascular ultrasound. Am J Cardiol. 2015;115:1056–62.CrossRefPubMed

17.

Kang SJ, Mintz GS, Witzenbichler B, et al. Age-related effects of smoking on culprit lesion plaque vulnerability as assessed by grayscale and virtual histology-intravascular ultrasound. Coron Artery Dis. 2015;26:476–83.CrossRefPubMed

18.

Kirtane AJ, Parikh PB, Stuckey TD, et al. Is there an ideal level of platelet P2Y12-receptor inhibition in patients undergoing percutaneous coronary intervention?: “window” analysis from the ADAPT-DES study (assessment of dual antiplatelet therapy with drug-eluting stents). JACC Cardiovasc Interv. 2015;8:1978–87.CrossRefPubMed

19.

Yun KH, Mintz GS, Witzenbichler B, et al. Relationship between platelet reactivity and culprit lesion morphology. An assessment from the ADAPT-DES intravascular ultrasound substudy. JACC Cardiovasc Imaging. 2016;9:849–54.CrossRefPubMed

20.

Guo J, Maehara A, Mintz GS, et al. A virtual histology intravascular ultrasound analysis of coronary chronic total occlusions. Catheter Cardiovasc Interv. 2013;81:464–70.CrossRefPubMed

21.

Kang SJ, Mintz GS, Park DW, et al. Tissue characterization of in-stent neointima using intravascular ultrasound radiofrequency data analysis. Am J Cardiol. 2010;106:1561–5.CrossRefPubMed

22.

Kang SJ, Mintz GS, Akasaka T, et al. Optical coherence tomographic analysis of in-stent neoatherosclerosis after drug-eluting stent implantation. Circulation. 2011;123:2954–63.CrossRefPubMed

23.

König A, Kilian E, Sohn HY, et al. Assessment and characterization of time-related differences in plaque composition by intravascular ultrasound-derived radiofrequency analysis in heart transplant recipients. J Heart Lung Transplant. 2008;27:302–9.CrossRefPubMed

24.

Hernandez JM, de Prada JA, Burgos V, et al. Virtual histology intravascular ultrasound assessment of cardiac allograft vasculopathy from 1 to 20 years after heart transplantation. J Heart Lung Transplant. 2009;28:156–62.CrossRefPubMed

25.

Jang JS, Jin HY, Seo JS, et al. Meta-analysis of plaque composition by intravascular ultrasound and its relation to distal embolization after percutaneous coronary intervention. Am J Cardiol. 2013;111:968–72.CrossRefPubMed

26.

Hong MK, Park DW, Lee CW, et al. Effects of statin treatments on coronary plaques assessed by volumetric virtual histology intravascular ultrasound analysis. JACC Cardiovasc Interv. 2009;2:679–88.CrossRefPubMed

27.

Park SJ, Kang SJ, Ahn JM, et al. Effect of statin treatment on modifying plaque composition: a double-blind, randomized study. J Am Coll Cardiol. 2016;67:1772–83.CrossRefPubMed

28.

Puri R, Libby P, Nissen SE, et al. Long-term effect of maximally intensive statin therapy on changes in coronary atheroma composition: insights from SATURN. Eur H J Cardiovasc Imaging. 2014;15:380–8.CrossRef

29.

Serruys PW, Gracía-Gracía HM, Buszman P, et al. Effect of the direct lipoprotein-associated phospholipase A₂ inhibitor darapladib on human coronary atherosclerotic plaque. Circulation. 2008;118:1172–82.CrossRefPubMed

30.

Kubo T, Maehara A, Mintz GS, et al. The dynamic nature of coronary artery lesion morphology assessed by serial virtual histology intravascular ultrasound tissue characterization. J Am Coll Cardiol. 2010;55:1590–7.CrossRefPubMed

31.

Zhao Z, Witzenbichler B, Mintz GS, et al. Dynamic nature of nonculprit coronary artery lesion morphology in STEMI. A serial IVUS analysis from the HORIZONS-AMI trial. JACC Cardiovasc Imaging. 2013;6:86–95.CrossRefPubMed

32.

Calvert PA, Obaid DR, O’Sullivan M, et al. Association between IVUS findings and adverse outcomes in patients with coronary artery disease. The VIVA (VH-IVUS in vulnerable atherosclerosis) study. JACC Cardiovasc Imaging. 2011;4:894–901.CrossRefPubMed

33.

Cheng JM, Gracía-Gracía HM, de Boer SP, et al. In vivo detection of high-risk coronary plaques by radiofrequency intravascular ultrasound and cardiovascular outcome: results of the ATHEROREMO-IVUS study. Eur Heart J. 2014;35:639–47.CrossRefPubMed

34.

Yun KH, Mintz GS, Farhat N, et al. Relation between angiographic lesion severity, vulnerable plaque morphology and futures adverse cardiac events (from the providing regional observations to study predictors of events in the coronary tree study). Am J Cardiol. 2012;110:471–7.CrossRefPubMed

35.

Xu Y, Mintz GS, Tam A, et al. Prevalence, distribution, predictors, and outcomes of patients with calcified nodules in native coronary arteries. A 3-vessel intravascular ultrasound analysis from providing regional observations to study predictors of events in the coronary tree (PROSPECT). Circulation. 2012;126:537–45.CrossRefPubMed

36.

Dohi T, Mintz GS, McPherson JA, et al. Non-fibroatheroma lesion phenotype and long-term clinical outcomes. A substudy analysis from the PROSPECT study. JACC Cardiovasc Img. 2013;6:908–16.CrossRef

37.

Inaba S, Mintz GS, Farhat NZ, et al. Impact positive and negative lesion site remodeling on clinical outcomes. Insights from PROSPECT. JACC Cardiovasc Imaging. 2014;7:70–8.CrossRefPubMed

38.

Xie Y, Mintz GS, Yang J, et al. Clinical outcome of nonculprit plaque ruptures in patients with acute coronary syndrome in the PROSPECT study. JACC Cardiovasc Imaging. 2014;7:397–405.CrossRefPubMed

Titel: Clinical Utility of Virtual Histology Intravascular Ultrasound
verfasst von: Akiko Maehara
Gary S. Mintz
Publikationsdatum: 01.09.2017
Verlag: Springer US
Erschienen in: Current Cardiovascular Imaging Reports / Ausgabe 9/2017
Print ISSN: 1941-9066
Elektronische ISSN: 1941-9074
DOI: https://doi.org/10.1007/s12410-017-9426-0

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