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Erschienen in: Reproductive Medicine and Biology 2/2015

01.04.2015 | Original Article

Clomiphene citrate affects the receptivity of the uterine endometrium

verfasst von: Koji Nakagawa, Masayo Kaneyama, Yayoi Nishi, Rie Sugiyama, Hiroshi Motoyama, Rikikazu Sugiyama

Erschienen in: Reproductive Medicine and Biology | Ausgabe 2/2015

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Abstract

Purpose

To investigate whether clomiphene citrate (CC) affects uterine receptivity or not, we evaluated pregnancy rates (PR) during the hormone replacement cycle (HRC) according to the period between the last day of CC administration and the day of embryo transfer (ET).

Methods

From March 2008 through March 2010, a total of 378 treatment cycles among 378 patients who received CC and had to avoid fresh ET due to a thin uterine endometrium were recruited. All patients underwent thawed ET using HRC. PRs were evaluated according to the period between the last CC treatment and the day of ET.

Results

PR for the groups in which the period between the last CC treatment and the day of ET increased to more than 91 days were significantly higher than that for group in which the period was less than 90 days (p < 0.05).

Conclusions

A lower PR was shown by the patients who underwent thawed ET in the HRC within 90 days after their last CC treatment, which shows that CC affects the receptivity of the uterine endometrium.
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Metadaten
Titel
Clomiphene citrate affects the receptivity of the uterine endometrium
verfasst von
Koji Nakagawa
Masayo Kaneyama
Yayoi Nishi
Rie Sugiyama
Hiroshi Motoyama
Rikikazu Sugiyama
Publikationsdatum
01.04.2015
Verlag
Springer Japan
Erschienen in
Reproductive Medicine and Biology / Ausgabe 2/2015
Print ISSN: 1445-5781
Elektronische ISSN: 1447-0578
DOI
https://doi.org/10.1007/s12522-014-0195-z

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