Erschienen in:
16.06.2016 | Case Report
Colitis during new direct-acting antiviral agents (DAAs) therapy with sofosbuvir, simeprevir and ribavirin for genotype 1b hepatitis C
verfasst von:
Ilaria Izzo, Paola Zanotti, Claudia Chirico, Salvatore Casari, Vincenzo Villanacci, Marianna Salemme, Luciano Biasi, Elena Festa, Francesco Castelli
Erschienen in:
Infection
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Ausgabe 6/2016
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Abstract
Since 2014 several direct-acting antivirals (DAAs) have been made available, allowing interferon-free antiviral treatments with high sustained virological response rates. Side effects are, however, a real challenge during treatment. Sarkar et al. recently published a case of colitis following initiation of sofosbuvir and simeprevir for genotype 1 hepatitis C. We report the case of a patient with no prior history of inflammatory bowel disease, who developed significant bloody diarrhea within 3 weeks of sofosbuvir/simeprevir/ribavirin initiation. Colonoscopy and biopsy suggested a drug-induced colitis.