Skip to main content
Erschienen in: International Journal of Clinical Oncology 2/2015

01.04.2015 | Review Article

Combination of molecular-targeted drugs with endocrine therapy for hormone-resistant breast cancer

verfasst von: Shigehira Saji, Reiko Kimura-Tsuchiya

Erschienen in: International Journal of Clinical Oncology | Ausgabe 2/2015

Einloggen, um Zugang zu erhalten

Abstract

Overcoming resistance to endocrine therapy is the most intensive research area in estrogen receptor (ER)-positive breast cancer. A strategy to restore endocrine sensitivity using molecular-targeted drugs such as mammalian target of rapamycin inhibitor everolimus along with endocrine therapy has already been used as a treatment option after the progression of previous aromatase inhibitor therapy. Phase II/III clinical trials of several signal pathway inhibitors and cyclin-dependent kinase 4/6 inhibitors are underway. In addition, a randomized phase II trial of the histone deacetylase inhibitor entinostat showed interesting findings. In this review, we summarize the mechanistic principles of combination therapy of molecular-targeted drugs with endocrine therapy by using a hybrid car model.
Literatur
1.
Zurück zum Zitat Giordano SH, Buzdar AU, Smith TL, et al (2004) Is breast cancer survival improving? Cancer 100(1):44–52 Giordano SH, Buzdar AU, Smith TL, et al (2004) Is breast cancer survival improving? Cancer 100(1):44–52
2.
Zurück zum Zitat Saad ED, Katz A, Buyse M (2010) Overall survival and post-progression survival in advanced breast cancer: a review of recent randomized clinical trials. J Clin Oncol 28(11):1958–1962PubMedCrossRef Saad ED, Katz A, Buyse M (2010) Overall survival and post-progression survival in advanced breast cancer: a review of recent randomized clinical trials. J Clin Oncol 28(11):1958–1962PubMedCrossRef
3.
Zurück zum Zitat Broglio KR, Berry DA (2009) Detecting an overall survival benefit that is derived from progression-free survival. J Natl Cancer Inst 101(23):1642–1649PubMedCentralPubMedCrossRef Broglio KR, Berry DA (2009) Detecting an overall survival benefit that is derived from progression-free survival. J Natl Cancer Inst 101(23):1642–1649PubMedCentralPubMedCrossRef
4.
5.
Zurück zum Zitat Shien T, Nakamura K, Shibata T et al (2012) A randomized controlled trial comparing primary tumour resection plus systemic therapy with systemic therapy alone in metastatic breast cancer (PRIM-BC): Japan Clinical Oncology Group Study JCOG1017. Jpn J Clin Oncol 42(10):970–973PubMedCrossRef Shien T, Nakamura K, Shibata T et al (2012) A randomized controlled trial comparing primary tumour resection plus systemic therapy with systemic therapy alone in metastatic breast cancer (PRIM-BC): Japan Clinical Oncology Group Study JCOG1017. Jpn J Clin Oncol 42(10):970–973PubMedCrossRef
6.
Zurück zum Zitat Niikura N, Hayashi N, Masuda N et al (2014) Treatment outcomes and prognostic factors for patients with brain metastases from breast cancer of each subtype: a multicenter retrospective analysis. Breast Cancer Res Treat 147(1):103–112PubMedCrossRef Niikura N, Hayashi N, Masuda N et al (2014) Treatment outcomes and prognostic factors for patients with brain metastases from breast cancer of each subtype: a multicenter retrospective analysis. Breast Cancer Res Treat 147(1):103–112PubMedCrossRef
7.
Zurück zum Zitat Niikura N, Saji S, Tokuda Y et al (2014) Brain Metastases in Breast Cancer. Jpn J Clin Oncol 44(12):1133–1140PubMedCrossRef Niikura N, Saji S, Tokuda Y et al (2014) Brain Metastases in Breast Cancer. Jpn J Clin Oncol 44(12):1133–1140PubMedCrossRef
8.
Zurück zum Zitat Baselga J, Campone M, Piccart M et al (2012) Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med 366(6):520–529PubMedCrossRef Baselga J, Campone M, Piccart M et al (2012) Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med 366(6):520–529PubMedCrossRef
10.
11.
Zurück zum Zitat Finn RS, Crown JP, Lang I et al (2014) The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study. Lancet Oncol S1470–2045(14):71159–71163 Finn RS, Crown JP, Lang I et al (2014) The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study. Lancet Oncol S1470–2045(14):71159–71163
12.
Zurück zum Zitat Thomas S, Munster PN (2009) Histone deacetylase inhibitor induced modulation of anti-estrogen therapy. Cancer Lett 280(2):184–191PubMedCrossRef Thomas S, Munster PN (2009) Histone deacetylase inhibitor induced modulation of anti-estrogen therapy. Cancer Lett 280(2):184–191PubMedCrossRef
13.
Zurück zum Zitat Yardley DA, Ismail-Khan RR, Melichar B et al (2013) Randomized phase II, double-blind, placebo-controlled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive breast cancer progressing on treatment with a nonsteroidal aromatase inhibitor. J Clin Oncol 31(17):2128–2135PubMedCrossRef Yardley DA, Ismail-Khan RR, Melichar B et al (2013) Randomized phase II, double-blind, placebo-controlled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive breast cancer progressing on treatment with a nonsteroidal aromatase inhibitor. J Clin Oncol 31(17):2128–2135PubMedCrossRef
14.
Zurück zum Zitat Munster PN, Thurn KT, Thomas S et al (2011) A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer. Brit J Cancer 104(12):1828–1835PubMedCentralPubMedCrossRef Munster PN, Thurn KT, Thomas S et al (2011) A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer. Brit J Cancer 104(12):1828–1835PubMedCentralPubMedCrossRef
15.
Zurück zum Zitat Wolff AC, Lazar AA, Bondarenko I et al (2013) Randomized phase III placebo-controlled trial of letrozole plus oral temsirolimus as first-line endocrine therapy in postmenopausal women with locally advanced or metastatic breast cancer. J Clin Oncol 31(2):195–202PubMedCentralPubMedCrossRef Wolff AC, Lazar AA, Bondarenko I et al (2013) Randomized phase III placebo-controlled trial of letrozole plus oral temsirolimus as first-line endocrine therapy in postmenopausal women with locally advanced or metastatic breast cancer. J Clin Oncol 31(2):195–202PubMedCentralPubMedCrossRef
Metadaten
Titel
Combination of molecular-targeted drugs with endocrine therapy for hormone-resistant breast cancer
verfasst von
Shigehira Saji
Reiko Kimura-Tsuchiya
Publikationsdatum
01.04.2015
Verlag
Springer Japan
Erschienen in
International Journal of Clinical Oncology / Ausgabe 2/2015
Print ISSN: 1341-9625
Elektronische ISSN: 1437-7772
DOI
https://doi.org/10.1007/s10147-015-0799-2

Weitere Artikel der Ausgabe 2/2015

International Journal of Clinical Oncology 2/2015 Zur Ausgabe

Adjuvante Immuntherapie verlängert Leben bei RCC

25.04.2024 Nierenkarzinom Nachrichten

Nun gibt es auch Resultate zum Gesamtüberleben: Eine adjuvante Pembrolizumab-Therapie konnte in einer Phase-3-Studie das Leben von Menschen mit Nierenzellkarzinom deutlich verlängern. Die Sterberate war im Vergleich zu Placebo um 38% geringer.

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

25.04.2024 NSCLC Nachrichten

Das Risiko für Rezidiv oder Tod von Patienten und Patientinnen mit reseziertem ALK-positivem NSCLC ist unter einer adjuvanten Therapie mit dem Tyrosinkinase-Inhibitor Alectinib signifikant geringer als unter platinbasierter Chemotherapie.

Bei Senioren mit Prostatakarzinom auf Anämie achten!

24.04.2024 DGIM 2024 Nachrichten

Patienten, die zur Behandlung ihres Prostatakarzinoms eine Androgendeprivationstherapie erhalten, entwickeln nicht selten eine Anämie. Wer ältere Patienten internistisch mitbetreut, sollte auf diese Nebenwirkung achten.

ICI-Therapie in der Schwangerschaft wird gut toleriert

Müssen sich Schwangere einer Krebstherapie unterziehen, rufen Immuncheckpointinhibitoren offenbar nicht mehr unerwünschte Wirkungen hervor als andere Mittel gegen Krebs.

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.