Pulmonary vein stenosis (PVS) is an uncommon but potentially serious complication following catheter ablation for atrial fibrillation (AF) [1]. Obviously, in symptomatic cases with severe PVS, early PVS stenting is needed to restore pulmonary flow [2, 3]. However, high risk of cardiac thrombosis remains if AF is recurrent. In such situations with co-existing bleeding complication, left atrial appendage occlusion (LAAO), currently regarded as a non-inferior alternative to anticoagulation in patients with non-valvular AF [4, 5], is useful to reduce the risk of thrombosis and bleeding. Here, we report a case of simultaneous percutaneous PVS stenting and LAAO to resolve the dilemma.

A 67-year-old man with diabetes, hypertension and a history of stroke underwent radiofrequency pulmonary vein (PV) isolation for persistent AF 1 year ago. Six months later he developed recurrent respiratory infection and massive hemoptysis. Electrocardiogram showed recurrence of AF. Warfarin was initially started but discontinued due to hemoptysis. Metoprolol was used for rate control. Computed tomography pulmonary angiography (CTPA) revealed severe left PV stenosis (Fig. 1a). He was admitted in our hospital for further treatment.

The patient was at high risk of AF-related stroke (CHA₂DS₂-VASc score = 5) and bleeding (HAS-BLED score = 3). In addition, risk of PV re-stenosis and recurrence of hemoptysis made long-term oral anticoagulation unfavorable in this patient.

We thus attempted to combine percutaneous PVS stenting and LAAO to resolve the problem. For percutaneous PVS stenting, we started with left pulmonary artery wedge angiography and direct selective PV angiography. As a result, severe stenosis at the ostium of left superior and inferior PV were visualized. New vascular plexus distal to the stenosis was highly suspected as the source of hemorrhage (Fig. 1b, c). Step-by-step balloon dilation of the conduit was firstly performed, and then two relatively big bare metal stents (9*25 mm and 8*27 mm; Boston Scientific, Natick, Massachusetts, USA) were successfully deployed in the proximal left superior and inferior PV respectively. PV angiography demonstrated no residual stenosis, rupture or dissection of the lesion (Fig. 1d, e). The transstenotic pressure gradient was decreased from 22 mmHg to 0 mmHg. Pulmonary vein caliber was significantly increased from 2.1 mm to 8.5 mm, and pulmonary artery pressure was decreased from 52/21 mmHg (31 mmHg) to 32/20 mmHg (24 mmHg). For LAAO, a Watchman Double Curve Access System was advanced into left atrium (LA) over the guidewire. Left atrial appendage (LAA) angiography revealed the whole lobe (Fig. 1f), and the ostial diameter was measured to be 23–25 mm by angiography and transesophageal echocardiography (TEE) views. Thereafter, a 30 mm Watchman occluder was deployed under fluoroscopy and TEE guidance (Fig. 1g, h). Once no significant peridevice leak was found and all release criteria were confirmed, the device was fully released. Heparin (80 IU/kg) was used during the procedure and activated clotting time was maintained as 250 s - 350 s.

After the procedure, the patient experienced immediate relief of symptoms. Then he received a combination of Aspirin and Clopidogrel for 6 months followed by Aspirin only indefinitely. The patient was followed at 3, 6 and 12 months. He remained asymptomatic without bleeding recurrence. CT scan was performed at 6 months and showed restored pulmonary venous flow (Fig. 2a), no in-stent restenosis (Fig. 2b, c) and no device related thrombosis (DRT) with regard to Watchman (Fig. 2d).

PVS after radiofrequency ablation is an uncommon but serious complication [6]. In symptomatic cases, PVS stenting can provide hemodynamic relief of pulmonary circulation [2]. However, like our patient, who had a bleeding complication and relative contraindication to chronic oral anticoagulation with warfarin or NOACs, the potential risk of LAA thrombosis and concomitant stroke are challenging. Re-Do ablations are possible in PVS after stents implantation, but the clinical benefit should be carefully considered and ostial ablation should be avoided [7]. Thus, stroke prophylaxis is of significance in the situation. While this case is performed combining with LAAO, these risks could be substantially reduced [8].

The current case illustrates the safety and feasibility of simultaneous PVS stenting and LAAO in such situation. Our experience of this procedure is that PV stenting should be first successfully performed; left superior PV stent should not be placed too close to the LA body. Sequentially, the Watchman Access Sheath should be advanced slowly to avoid interfering with PV stent.

In conclusion, the strategy of PVS stenting combined with LAAO can solve the dilemma of bleeding and thromboembolism. During the procedure, we deployed the large stent in the stenotic PV followed by dual antiplatelet therapy per the ASAP registry regimen [9]. The patient had good short and mid-term results upon follow up.