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22.08.2023 | Common Data Elements for Disorders of Consciousness

Common Data Elements for Disorders of Consciousness: Recommendations from the Electrophysiology Working Group

verfasst von: Elizabeth E. Carroll, Caroline Der-Nigoghossian, Ayham Alkhachroum, Brian Appavu, Emily Gilmore, Julie Kromm, Benjamin Rohaut, Mario Rosanova, Jacobo Diego Sitt, Jan Claassen, the Curing Coma Campaign and its Contributing Members

Erschienen in: Neurocritical Care | Ausgabe 3/2023

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Abstract

Background

Electroencephalography (EEG) has long been recognized as an important tool in the investigation of disorders of consciousness (DoC). From inspection of the raw EEG to the implementation of quantitative EEG, and more recently in the use of perturbed EEG, it is paramount to providing accurate diagnostic and prognostic information in the care of patients with DoC. However, a nomenclature for variables that establishes a convention for naming, defining, and structuring data for clinical research variables currently is lacking. As such, the Neurocritical Care Society’s Curing Coma Campaign convened nine working groups composed of experts in the field to construct common data elements (CDEs) to provide recommendations for DoC, with the main goal of facilitating data collection and standardization of reporting. This article summarizes the recommendations of the electrophysiology DoC working group.

Methods

After assessing previously published pertinent CDEs, we developed new CDEs and categorized them into “disease core,” “basic,” “supplemental,” and “exploratory.” Key EEG design elements, defined as concepts that pertained to a methodological parameter relevant to the acquisition, processing, or analysis of data, were also included but were not classified as CDEs.

Results

After identifying existing pertinent CDEs and developing novel CDEs for electrophysiology in DoC, variables were organized into a framework based on the two primary categories of resting state EEG and perturbed EEG. Using this categorical framework, two case report forms were generated by the working group.

Conclusions

Adherence to the recommendations outlined by the electrophysiology working group in the resting state EEG and perturbed EEG case report forms will facilitate data collection and sharing in DoC research on an international level. In turn, this will allow for more informed and reliable comparison of results across studies, facilitating further advancement in the realm of DoC research.

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Titel: Common Data Elements for Disorders of Consciousness: Recommendations from the Electrophysiology Working Group
verfasst von: Elizabeth E. Carroll
Caroline Der-Nigoghossian
Ayham Alkhachroum
Brian Appavu
Emily Gilmore
Julie Kromm
Benjamin Rohaut
Mario Rosanova
Jacobo Diego Sitt
Jan Claassen
the Curing Coma Campaign and its Contributing Members
Publikationsdatum: 22.08.2023
Verlag: Springer US
Erschienen in: Neurocritical Care / Ausgabe 3/2023
Print ISSN: 1541-6933
Elektronische ISSN: 1556-0961
DOI: https://doi.org/10.1007/s12028-023-01795-1

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