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19.08.2021 | Original Paper

Comparable outcomes of recycled autografts and allografts for reconstructions in patients with high-grade osteosarcoma

verfasst von: Kuan-Lin Chen, Chao-Ming Chen, Cheng-Fong Chen, Yu-Chi Cheng, Yu-Kuan Lin, Shang-Wen Tsai, Tain-Hsiung Chen, Po-Kuei Wu, Wei-Ming Chen

Erschienen in: International Orthopaedics | Ausgabe 11/2021

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Abstract

Purpose

This retrospective, single-centre study compares the clinical and radiographic outcomes of limb reconstruction using recycled autografts to that using allografts.

Methods

Patients with histopathologically verified high-grade osteosarcoma treated with wide bone resection and limb reconstruction using allografts or recycled autografts from January 1998 through December 2012 were retrospectively screened for enrolment eligibility. The final study cohort included 255 patients (allograft, 91; recycled autograft, 164). Data regarding post-operative complications, salvage treatment, and graft survival were collected. A modified International Society of Limb Salvage classification system was used to evaluate the radiographic findings.

Results

The time to graft–host union did not differ significantly between the two graft types. Patients receiving recycled autografts had fewer complications compared than did those receiving allografts (recycled autografts vs. allograft: structural failure, 4.3 vs. 13.2%; late infection, 2.4 vs. 7.7%; all p < 0.05). Complications occurred most frequently during the first three years after surgery, and the majority were manageable. The five year limb survival rate did not differ significantly between the two graft types (91.3 vs. 94.0%; p = 0.752). No local oncological recurrence was observed within the recycled autografts.

Conclusion

Recycled autografts and allografts are feasible options for biological limb reconstructions in terms of complications and graft survival after wide resection of osteosarcoma.

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Titel: Comparable outcomes of recycled autografts and allografts for reconstructions in patients with high-grade osteosarcoma
verfasst von: Kuan-Lin Chen
Chao-Ming Chen
Cheng-Fong Chen
Yu-Chi Cheng
Yu-Kuan Lin
Shang-Wen Tsai
Tain-Hsiung Chen
Po-Kuei Wu
Wei-Ming Chen
Publikationsdatum: 19.08.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: International Orthopaedics / Ausgabe 11/2021
Print ISSN: 0341-2695
Elektronische ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-021-05161-8

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