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01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

BMC Neurology 1/2015

Comparing interventions and exploring neural mechanisms of exercise in Parkinson disease: a study protocol for a randomized controlled trial

Zeitschrift:
BMC Neurology > Ausgabe 1/2015
Autoren:
Gammon M Earhart, Ryan P Duncan, John L Huang, Joel S Perlmutter, Kristen A Pickett
Wichtige Hinweise

Competing interests

This work is funded by the National Institutes of Health.

Authors’ contributions

GE conceived the idea for this study and designed it along with KP, RD and JSP. All authors were involved in drafting and revising the manuscript, with JH playing a key role in initial drafting. All authors will be involved in data collection, analysis and/or manuscript preparation as the study proceeds. All authors read and approved the final manuscript.

Abstract

Background

Effective treatment of locomotor dysfunction in Parkinson disease (PD) is essential, as gait difficulty is an early and major contributor to disability. Exercise is recommended as an adjunct to traditional treatments for improving gait, balance, and quality of life. Among the exercise approaches known to improve walking, tango and treadmill training have recently emerged as two promising therapies for improving gait, disease severity and quality of life, yet these two interventions have not been directly compared to each other. Prior studies have been helpful in identifying interventions effective in improving gait function, but have done little to elucidate the neural mechanisms underlying functional improvements. The primary objective of the proposed work is to compare the effects of three community-based exercise programs, tango, treadmill training and stretching, on locomotor function in individuals with PD. In addition, we aim to determine whether and how these interventions alter functional connectivity of locomotor control networks in the brain.

Methods/Design

One hundred and twenty right-handed individuals with idiopathic PD who are at least 30 years of age will be assigned in successive waves to one of three community-based exercise groups: tango dancing, treadmill training or stretching (control). Each group will receive three months of exercise training with twice weekly one-hour group classes. Each participant will be evaluated at three time points: pre-intervention (baseline), post-intervention (3 months), and follow-up (6 months). All evaluations will include assessment of gait, balance, disease severity, and quality of life. Baseline and post-intervention evaluations will also include task-based functional magnetic resonance imaging (fMRI) and resting state functional connectivity MRI. All MRI and behavioral measures will be conducted with participants OFF anti-Parkinson medication, with behavioral measures also assessed ON medication.

Discussion

This study will provide important insights regarding the effects of different modes of exercise on locomotor function in PD. The protocol is innovative because it: 1) uses group exercise approaches for all conditions including treadmill training, 2) directly compares tango to treadmill training and stretching, 3) tests participants OFF medication, and 4) utilizes two distinct neuroimaging approaches to explore mechanisms of the effects of exercise on the brain.

Trial registration

ClinicalTrials.gov NCT01768832.
Literatur
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