Comparison of antimicrobial prescribing for dental and oral infections in England and Scotland with Norway and Sweden and their relative contribution to national consumption 2010–2016

Prescribing in dental practice has a relatively small but important contribution to the quantity of antibiotics prescribed in primary care. Dentists prescribe antibiotics to treat acute bacterial intra-oral infections and some cases of chronic periodontitis. The majority of acute dento-alveolar infections should be managed primarily by surgical or local measures to control the source of infection (extraction, root canal therapy or incision and drainage) with professional guidelines re-enforcing this basic tenet of infection source control in dental practice [1‐3]. However, there is evidence that there has been both inappropriate qualitative and quantitative prescribing for dental infections [4‐9].

The trend of antibiotic prescriptions over time is influenced by many factors, such as disease levels, access to dental services, prescribing guidelines, patients’ attitude toward antibiotic prescribing, and incidence of antimicrobial resistance (AMR) [6, 10]. The prevalence of untreated dental caries and severe periodontal diseases, which could lead to dento-alveolar infections can be described in terms of Years Lived with Disability (YLD) standardised rate per capita, which was highest in Scotland (0.579), followed by England (0.51), Norway (0.481) and then Sweden (0.473) [11]. Accurate estimations of AMR in bacterial populations isolated from acute dental infections are difficult to interpret. Review articles have reported resistance rates to vary between 9 and 54% [12]. The AMR data is confounded by changes in bacterial taxonomy, methods of susceptibility testing and breakpoints used. With increasing trends of antibiotic resistant infections across many bacterial species and clinical specialties, adoption of antimicrobial stewardship principles by all prescribers is vital. In addition, it is timely to remember that dental antibiotic use contributes to the selection pressure for development of AMR generally and not just linked to dental infections or oral pathogens [13‐15]. An important principle of antimicrobial stewardship is surveillance of antibiotic use and feedback to prescribers to drive quality improvement in the empirical use of antibiotics [16]. National data on antibiotic use by dentists can be used to identify priorities for antibiotic stewardship in dentistry and inform management and prescribing guidance. There are some reports of good outcomes following a variety of interventions [17].

The objective of this study was to compare the national use of antibiotics by dental prescribers in England and Scotland with Norway and Sweden. Report their relative contribution to the total national antibiotic consumption by outpatients, and review differences in prescribing patterns to ascertain whether lessons can be used to inform antimicrobial stewardships policies in the four countries.

A total of 21,719,095 dental prescriptions were dispensed in England, 2,591,077 Scotland, 1,048,568 Norway and 1, 717,859 were in Sweden, during the study period. The number of prescriptions issued by dentists per year in England, Scotland, Norway and Sweden are listed in Table 1 and the average prescription per dentist per year in Norway and Sweden versus England and Scotland is presented in Fig. 1.

The highest annual rate of antibiotic prescribing per dentist was in England in 2011 (n = 171), by 2016 this had declined to 133 antibiotic prescriptions per year (Fig. 1), this represented the highest number of prescriptions per dentist from all four countries. In Scotland the prescription rate per dentist peaked in 2012 (n = 119) and had declined to 87 per annum by 2016. Norway had the lowest rates of prescriptions per dentist (peaking at 31 in 2014) with a decline in prescriptions to 26 per year by 2016. Swedish prescribing levels were highest in 2010 (n = 36) and declined to 28 per annum by 2016. The dental contribution to the total of antibiotics prescribed in the community for each Country over the period 2010–16 was 8, 6, 8, and 7% for England, Scotland, Norway and Sweden. The proportion (%) of Phenoxymethyl penicillin and Amoxicillin dispensed in Norway and Sweden versus England and Scotland by dentists to the total antibiotics dispensed in the community by general dental practitioners is presented in Fig. 2.

The proportion (%) of Metronidazole and Clindamycin dispensed in Norway and Sweden versus England and Scotland to the total antibiotics dispensed by general dental practitioners is presented in Fig. 3.

The DID_100,000 attributed to dental prescriptions in England, Scotland, Norway and Sweden in every year from 2010 to 2016 are presented in Table 2. Table 3 presents the average DID_100,000 attributed to dental prescriptions in the study period.

The Global Burden of Disease Study 2016 estimated that oral diseases affected half of the world’s population [20]. Untreated dental decay, which could lead to dento-alveloar infections, in permanent teeth affects 2.3 billion people, and untreated dental decay in primary teeth affects more than 560 million children worldwide. Severe periodontal diseases that may result in tooth loss and affect general health and wellbeing, was estimated to be the 11th most prevalent disease globally [20]. Dentists prescribe a panel of antibiotics to treat and manage acute dento-alveloar infections. Differences in total volumes of antibiotics prescribed as well as differences in prescription pattern in different geographical locations to treat and manage dento-alveloar infections could be explained by differences in dental disease patterns susceptibility/resistance profile of oral bacteria. One of the main findings of the current study is that the mean number of prescriptions per dentist in the study period in Norway and Sweden is 29 and 32 prescriptions, respectively. In England and Scotland, the mean number of prescriptions per dentist in the study period is 156 and 104 prescriptions, respectively. In addition, the narrower spectrum Phenoxymethyl penicillin are more widely prescribed in Norway and Sweden whilst the broader spectrum Amoxicillin is largely prescribed in England and Scotland. The factors that influence the difference in prescription rate between dentists in these countries warranty further investigation.

This is the first study to use National data to assess antibiotic prescription volume and prescription patterns for dental infections in four northern European countries. A total of 27,076,599 prescriptions issued by dentists working in England, Scotland, Norway and Sweden over the period 2010–2016 were analysed in this study. Prescriptions for dental infections accounted on average for 6–8% of the total prescriptions in Primary care from these countries. An important caveat of this data is that in the UK it probably underestimates the actual number of antibiotic prescriptions since the data source does not capture private prescriptions, and the number of patients receiving private treatment is estimated to be around 33% in the UK [21].

All countries show a decline in antibiotic prescriptions since the start of the analysis period indicating that stewardship initiatives in these countries are having an overall downward effect on prescription volumes. From 2010 to 2016, Sweden dentists reduced their total number of prescriptions by 19% followed by England 18%, Scotland 13% and then Norway by 4%. Although the least reduction of the total number of prescriptions was in Norway, however, the DID_100,000 and number of prescriptions per dentists in Norway are still the lowest for all antibiotics, except Clindamycin, compared to England, Scotland and Sweden. The significantly lower prescribing rates in other Northern European countries compared to the UK is a pattern observed in other Specialties [22]. Lower prescribing rates in Norway and Sweden may also be due to differences in diseases levels in addition to prescribing habits. However, the findings reported in our study have several limitations such as, the UK data only relates to NHS primary care dentistry and excludes private provision and hospital data. As with all prescribing, this data takes no account of whether the prescribing was appropriate or not and does not include dose, frequency or duration. The results and conclusions must be interpreted in the context of these limitations.

One of the more marked differences in the antibiotic prescribing patterns between the UK and Northern Scandinavian countries is the selection of Amoxicillin over Phenoxymethyl penicillin. In the UK the British National Formulary highlights either Amoxicillin (500 mg every 8 h in adults for 5 days) or Metronidazole (400 mg every 8 hourly in adults for 3–7 days) [23]. The dose and duration for Phenoxymethyl penicillin in adults is 500 mg 6 hourly for 5 days. UK professional society guidance, such as the Faculty of General Dental Practice (FGDP) and the Scottish Dental Clinical Effectiveness Programme (SDCEP) also highlights the first choice of Amoxicillin for use in acute dento-alveolar (dental abscess) infections [2, 3]. In Norway and Sweden, the recommendations for treatment choice for acute dento-alveolar infections are given in the Norwegian Directorate of Health [1] which recommends Phenoxymethyl penicillin (660 mg every 6 hourly in adults for 5 days) and in Sweden the recommended regime by the Swedish Medical Products Agency is 1,6 g Phenoxymethyl penicillin every 8 h for 5–7 days [24]. Prescription of Phenoxymethyl penicillin in Norway and Sweden as the first line of drug to treat infections in outpatients is common not only in dentistry but also in general medicine for management of upper respiratory tract infections [1]. In Norway for example, the prescription of Phenoxymethyl penicillin contributes to about 70% of the total antibiotic prescriptions in the country [18].

The narrower spectrum Phenoxymethyl penicillin are more widely prescribed in Norway and Sweden whilst the broader spectrum Amoxicillin is largely prescribed in England and Scotland. The Amoxicillin DID_100,000 for Norway and Sweden is at least 10 times less than that of England and Scotland. Similar pattern is also found in other European countries where DID_100,000 attributed to dental prescription of Amoxicillin in Belgium is approximately 10 times higher than that of Norway and Sweden [25]. The question arises whether the differences between Scandinavia and the UK in prescription behaviour among dentists is because of differences in susceptibility among oral bacteria or because of attitudes toward antibiotic prescribing influenced by educational curriculum, stewardship programs and national guidelines. Of further interest is the proportionally higher use of clindamycin in Norway and Sweden, in the UK one of the drivers to reduce prescribing of clindamycin is it’s link to C. difficile infection. It is unclear why there is a higher prescription rate for this antibiotic in Norway and Sweden.

The majority of oral penicillins are absorbed, so that they yield peak levels 1–2 h after ingestion with approximately 60 and 75% absorption following oral administration for Phenoxymethyl penicillin and Amoxicillin, respectively [26]. Penicillins are bound to proteins (usually albumin) to varying degrees ranging from 17% for Amoxicillin to 80% for Pencillin V. Only unbound drug exerts antibacterial activity, because the bound drug is not free to interact with penicillin binding proteins. However, protein binding is a reversible process and it is possible for bound protein to be desorbed and then released to interact with bacteria in tissue [26]. Penicillin’s are well distributed to most areas of the body, and their levels in areas affected by dental abscesses are sufficient in the presence of inflammation to inhibit most susceptible bacteria [27].

Phenoxymethyl penicillin and Amoxicillin belong to the time-dependent killing agents, with a target to maintain concentrations greater than the MIC for greater than or equal to 75% of the dosing interval). Phenoxymethyl penicillin, are most active against non-ß-lactamase producing Gram-positive bacteria (viridans group streptococci, anginosus group streptococci), anaerobes and selected Gram-negative cocci. Gram positive bacteria inhibited by natural pencillins in general are more susceptible to Phenoxymethyl penicillin than to semisynthetic pencillins like Amoxicillin [28, 29]. Typical MIC’s for common Gram positive streptococci from dental infections, such as viridans streptococci are 0.01 and 0.05 μg/ml for Phenoxymethyl penicillin and Amoxicillin [26]. For anginosus streptococci these are invariably sensitive to Phenoxymethyl penicillin and Amoxicillin [30]. Amoxicillin possess the same spectrum as Phenoxymethyl penicillin, plus they are more active against Gram negative cocci and members of the family Enterobacteriaceae [31]. Both agents are susceptible to a wide range of ß-lactamases.

Antibiotic resistance in microbes recovered from the acute dental abscess has been reported to be increasing (with the exception of Metronidazole) in some populations studied over the last few decades [32‐35]. Care must be taken in interpretation of studies due to differences in details of the identification of isolates, selection of appropriate breakpoints and their relevance to oral infections and lack of details on MICs (for example, not all studies report MIC₉₀ data). This is illustrated by reports of resistance rates for Amoxicillin ranging from 9 to 54% of common isolates from acute dental abscesses [12]. However, analysis of a number of reports does reveal a trend that the least susceptible isolates from an acute abscess are more likely to be black-pigmented Prevotella species, such as Prevotella intermedia. Resistance to macrolides appears to have a higher prevalence in the ‘viridans group streptococci’, anaerobic streptococci and Prevotella species [36‐38]. The prevalence of resistance to lincosamides, such as clindamycin, is low. For example, Kuriyama et al. reported on 664 isolates from 163 patients and found a clindamycin MIC₉₀ of 2 mg/L for 15 strains of penicillin resistant anaerobic streptococci, with all the remaining isolates (649) having a clindamycin MIC₉₀ less than 0.5 mg/L. Similar low levels of clindamycin resistance have been found in the UK and elsewhere [37, 39].

Differences in the prescribing patterns of Metronidazole are also markedly different between the UK and Northern Scandinavian countries. In England and Scotland prescription of Metronidazole in accounts for approximately 52–57% of all Metronidazole prescribed in primary care [40, 41]. In Norway and Sweden, metronidazole prescription by dentists account for 19 and 16%, respectively, of the total metronidazole prescription. The driving force for this prescribing pattern is unclear, with UK guidance provided in the BNF/FGDP/SDCEP which recommends Amoxicillin as a first line agent with clindamycin or clarithromycin as a second line agent or in patients allergic to penicillins [2, 3, 23]. Metronidazole is advocated (SDCEP) as an alternative agent in penicillin allergic patients and in the first line management of necrotising gingivitis and pericoronitis. Additional guidance (SDCEP) suggests addition of metronidazole to amoxicillin in cases of severe odontogenic infection [3]. The treatment course for Metronidazole in the UK is 400 mg every 8 h for 5 days [23]. In Norway and Sweden the recommendations for prescribing metronidazole in dental infections is also 400 mg every 8 h for 5–10 days [1, 24].

The high levels of use of Metronidazole for the management of dental infections in England and Scotland is of concern in the context of potential increase in Metronidazole resistance in anaerobic bacteria populations [42]. This is compounded by poor surveillance systems in dental infections for either detection of antibiotic resistance to beta-lactams or Metronidazole.

The prescribing levels of the macrolides (clarithromycin/erythromycin) are as expected for their recommended use as second line agents in patients allergic to penicillins. Spiramycin is an antibiotic belong to the macrolide group of antibiotics. It has a spectrum against aerobic and anaerobic bacteria. This drug is prescribed by dentists in Norway and not by dentists in England, Scotland and Sweden, although Norwegian prescription guidelines do not encourage the use of this drug. The use of spiramycin as an adjunct to mechanical therapy for treatment of periodontal infections is recommended in the Norwegian Pharmaceutical Product Compendium (Felleskatalogen), which might explain the prescription of his drug in Norway.

In conclusion, this study has provided an in-sight into prescribing patterns for bacterial intra-oral infections managed by general dental practitioners from England and Scotland with Norway and Sweden. All four countries demonstrated reduction in overall numbers of items dispensed with lower prescribing patterns in Norway and Sweden. Other notable differences in prescribing patterns linked to first line choice of antibiotic between these countries existed with Phenoxymethyl penicillin the preferred choice in Scandinavia. There is some logic in a more widespread adoption of the use of the narrower spectrum Phenoxymethyl penicillin over Amoxicillin in the UK as it probably has a lesser impact on the normal flora without compromising treatment efficacy. Identification of high levels of Spiramycin prescribing in Norway may serve as a trigger for this country to review the prescribing guidance for the use of this antibiotic in managing chronic periodontal disease. Further work is required to understand the high levels of metronidazole prescriptions as this element of healthcare accounts for a significant contribution of selection pressure for the emergence of metronidazole resistance.