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International Journal of Diabetes in Developing Countries

Erschienen in:

01.09.2015 | Original Article

Complication profiles and their associated factors in Malaysian adult type 2 diabetes mellitus—an analysis of ADCM registry

verfasst von: Boon-How Chew, Ping-Yein Lee, Ai-Theng Cheong, Mastura Ismail, Mohamad-Adam Bujang, Jamaiyah Haniff, Sri-Wahyu Taher, Pik-Pin Goh

Erschienen in: International Journal of Diabetes in Developing Countries | Ausgabe 3/2015

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Abstract

Early detection and treatment of risk factors in type 2 diabetes mellitus (T2D) have been proven in reducing complications, improving survival and quality of life. This study aimed to examine an overall diabetes-related complication profiles and their associated factors in adult T2D. Adult diabetes control and management (ADCM) is a prospective registry that included patients with T2D in 2009. Complication profiles were reported descriptively. Multivariate analyses adjusted for differences in patient characteristics were used to determine the associated factors for diabetes-related complications categorised as microvascular complication (microCx) such as retinopathy and nephropathy and macrovascular complication (macroCx) such as ischaemic heart disease and cerebrovascular accident and both complications (combined microCx and macroCx). Complete data were available for 57,780 patients (81.5 %) with a mean age of 58.3 (SD 11.27) years; 59.7 % were female. About one fifth (10,834/57,780) of T2D patients were diagnosed with at least one complication. Ethnicity, gender, duration of T2D and co-morbids, under hospitals with specialist (HS) care, glycaemic and low-density lipoprotein-cholesterol (LDL-C) targets were associated with complications. When compared to T2D patients without complication, patients who were older (OR 1.03), male (OR 1.48), had longer duration of diabetes (OR 1.04) and hypertension (OR 1.03) and under the care HS (OR 13.64) were more likely to have both complications. T2D patients had moderate morbidity burden. Older age and male gender were two main risk factors of all types of complications. T2D patients with these associated factors should be monitored for prevention, screening and early treatment of diabetes-related complications. T2D patients under the HS care were noted to have also more complications could be due to HS had been centres of referral for advanced diabetes care rather than the result of HS care itself.

van Dieren S, Beulens JW, van der Schouw YT, Grobbee DE, Neal B. The global burden of diabetes and its complications: an emerging pandemic. Eur J Cardiovasc Prev Rehabil. 2010;17 Suppl 1:S3–8.CrossRefPubMed

Gholap N, Davies M, Patel K, Sattar N, Khunti K. Type 2 diabetes and cardiovascular disease in South Asians. Prim Care Diabetes. 2011;5:45–6.CrossRefPubMed

Chan JCN, Malik V, Jia W, Kadowaki T, Yajnik CS, Yoon K-H, et al. Diabetes in Asia. JAMA. 2009;301:2129–40.CrossRefPubMed

Zaini A. Where is Malaysia in the midst of the Asian epidemic of diabetes mellitus? Diabetes Res Clin Pract. 2000;50 Suppl 2:S23–8.CrossRefPubMed

Biessels GJ, Deary IJ, Ryan CM. Cognition and diabetes: a lifespan perspective. Lancet Neurol. 2008;7:184–90.CrossRefPubMed

Cizza G, Brown RJ, Rother KI. Rising incidence and challenges of childhood diabetes. A mini review. J Endocrinol Invest. 2012;35:541–6.PubMedCentralPubMed

Delahanty LM, Grant RW, Wittenberg E, Bosch JL, Wexler DJ, Cagliero E, et al. Association of diabetes-related emotional distress with diabetes treatment in primary care patients with type 2 diabetes. Diabet Med. 2007;24:48–54.CrossRefPubMed

Solli O, Stavem K, Kristiansen IS. Health-related quality of life in diabetes: the associations of complications with EQ-5D scores. Health Qual Life Outcome. 2010;8:18.CrossRef

Kim TH, Chun KH, Kim HJ, Han SJ, Kim DJ, Kwak J, et al. Direct medical costs for patients with type 2 diabetes and related complications: a prospective cohort study based on the korean national diabetes program. J Korean Med Sci. 2012;27:876–82.PubMedCentralCrossRefPubMed

10.

American Diabetes Association. Economic costs of diabetes in the U.S. In 2007. Diabetes Care. 2008: 596-615.

11.

Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 2008;359:1577–89.CrossRefPubMed

12.

Adler AI, Stratton IM, Neil HAW, Yudkin JS, Matthews DR, Cull CA, et al. Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study. BMJ. 2000;321:412–9.PubMedCentralCrossRefPubMed

13.

Chan JCN, Chan SP, Deerochanawong C, Go RT, Lee K-O, Ma RC-W, et al. Diabetic dyslipidaemia in Asian populations in the Western Pacific Region: what we know and don't know. Diabetes Res Clin Pract. 2011;1–13.

14.

Lundman B, Engstrom L. Diabetes and it's complications in a Swedish county. Diabetes Res Clin Pract. 1998;39:157–64.CrossRefPubMed

15.

Sarwar N, Gao P, Seshasai SR, Gobin R, Kaptoge S, Di Angelantonio E, et al. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet. 2010;375:2215–22.CrossRefPubMed

16.

Mafauzy M. Diabetes control and complications in public hospitals in Malaysia. Med J Malays. 2006;61:477–83.

17.

Mafauzy M. Diabetes control and complications in private primary healthcare in Malaysia. Med J Malays. 2005;60:212–7.

18.

Chew BH, Ghazali SS, Ismail M, Haniff J, Bujang MA. Age >/=60 years was an independent risk factor for diabetes-related complications despite good control of cardiovascular risk factors in patients with type 2 diabetes mellitus. Exp Gerontol. 2013;48(5):485–91.CrossRefPubMed

19.

Chew BH, Cheong AT, Ahmad Z, Ismail M. Men were suffering more complications of diabetes despite similar glycaemic control and better cardiovascular risk profile: the ADCM study 2008. J Mens Health. 2012;9:190–7.CrossRef

20.

Chew BH, Mastura I, Lee PY, Wahyu TS, Cheong AT, Zaiton A. Ethnic differences in glycaemic control and complications: the adult diabetes control and management (ADCM). Malays Med J Malays. 2011;66:244–8.

21.

Lee PY, Cheong AT, Zaiton A, Mastura I, Chew B-H, Sazlina SG, et al. Does ethnicity contribute to the control of cardiovascular risk factors among patients with type 2 diabetes? Asia Pac J Public Health. 2013;25(4):316–25.CrossRefPubMed

22.

Chew BH, Mastura I, Lee PY, Taher SW, Haniff J, Mustapha FI, et al. Determinants of uncontrolled dyslipidaemia among adult type 2 diabetes in Malaysia: the Malaysian Diabetes Registry 2009. Diabetes Res Clin Pract. 2012;96(3):339–47.CrossRefPubMed

23.

WHO Consultation. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Geneva: World Health Organisation; 1999. Report no. 99.2.

24.

Ministry of Health M. Management of type 2 diabetes mellitus. putrajaya: Technology, Health Section, Assessment Division, Medical Development; 2009.

25.

American Diabetes Association. Standards of medical care in diabetes—2012. Diabetes Care. 2012;35:S11–63.CrossRef

26.

Fonseca VA. Defining and Characterizing the Progression of Type 2 Diabetes. Diabetes Care. 2009;32:S151–6.PubMedCentralCrossRefPubMed

27.

Rückert I-M, Maier W, Mielck A, Schipf S, Völzke H, Kluttig A, et al. Personal attributes that influence the adequate management of hypertension and dyslipidemia in patients with type 2 diabetes. Results from the DIAB-CORE Cooperation. Cardiovasc Diabetol. 2012;11(1):120.PubMedCentralCrossRefPubMed

28.

Rahman S, Rahman T, Ismail AA, Rashid AR. Diabetes-associated macrovasculopathy: pathophysiology and pathogenesis. Diabetes Obes Metab. 2007;9:767–80.CrossRefPubMed

29.

Fox KM, Gerber Pharmd RA, Bolinder B, Chen J, Kumar S. Prevalence of inadequate glycemic control among patients with type 2 diabetes in the United Kingdom general practice research database: a series of retrospective analyses of data from 1998 through 2002. Clin Ther. 2006;28:388–95.CrossRefPubMed

30.

Wermeling PR, Gorter KJ, Stel HF, Rutten GE. Both cardiovascular and non-cardiovascular comorbidity are related to health status in well-controlled type 2 diabetes patients: a cross-sectional analysis. Cardiovasc Diabetol. 2012;11(1):121.PubMedCentralCrossRefPubMed

31.

Liu Z, Fu C, Wang W, Xu B. Prevalence of chronic complications of type 2 diabetes mellitus in outpatients—a cross-sectional hospital based survey in urban China. Health Qual Life Outcome. 2010;8:62.CrossRef

32.

Chuang LM, Tsai ST, Huang BY, Tai TY. The status of diabetes control in Asia—a cross-sectional survey of 24 317 patients with diabetes mellitus in 1998. Diabet Med. 2002;19:978–85.CrossRefPubMed

33.

Chew BH, Palikat JM, Nur Syamimi A, Nor Azillah A, See JK, Hafiz AR, et al. An audit of type 2 diabetes care in a Malaysian public community polyclinic. Pertanika J Sci Technol. 2012;20(1):97–102.

34.

Sazlina SG, Zailinawati AH, Zaiton A, Ong I. A clinical audit on diabetes care in two urban public primary care clinics in Malaysia. Malays J Med Health Sci. 2010;6(1):101–9.

35.

Mastura I, Chew BH, Lee PY, Cheong AT, Sazlina SG, Jamaiyah H, et al. Control and treatment profiles of 70,889 adult type 2 diabetes mellitus patients in Malaysia. Int J Collab Res Intern Med Public Health. 2011;3:98–113.

36.

Chan JC, Gagliardino JJ, Baik SH, Chantelot JM, Ferreira SR, Hancu N, et al. Multifaceted determinants for achieving glycemic control: the International Diabetes Management Practice Study (IDMPS). Diabetes Care. 2009;32:227–33.PubMedCentralCrossRefPubMed

37.

Institute for Public Health. National health morbidity survey IV. Putrajaya 2012.

38.

Chew BH, Mastura I, Shariff-Ghazali S, Lee PY, Cheong AT, Ahmad Z, et al. Determinants of uncontrolled hypertension in adult type 2 diabetes mellitus: an analysis of the Malaysian diabetes registry 2009. Cardiovasc Diabetol. 2012;11:54.PubMedCentralCrossRefPubMed

39.

George D. Early and intensive therapy for management of hyperglycemia and cardiovascular risk factors in patients with type 2 diabetes. Clin Ther. 2011;33:665–78.CrossRef

40.

Wandell PE, Gafvels C. Patients with type 2 diabetes aged 35-64 years at four primary health care centres in Stockholm County, Sweden. Prevalence and complications in relation to gender and socio-economic status. Diabetes Res Clin Pract. 2004;63:195–203.CrossRefPubMed

41.

Leelawattana R, Pratipanawatr T, Bunnag P, Kosachunhanun N, Suwanwalaikorn S, Krittiyawong S, et al. Thailand diabetes registry project: prevalence of vascular complications in long-standing type 2 diabetes. J Med Assoc Thai. 2006;89 Suppl 1:S54–9.PubMed

42.

Hammes HP. Pathophysiological mechanisms of diabetic angiopathy. J Diabetes Complicat. 2003;17:16–9.CrossRefPubMed

43.

Chan JC, So W, Ma RC, Tong PC, Wong R, Yang X. The complexity of vascular and non-vascular complications of diabetes: the Hong Kong Diabetes Registry. Curr Cardiovasc Risk Rep. 2011;5:230–9.PubMedCentralCrossRefPubMed

44.

Tong SF, Low WY, Ng CJ. Profile of men's health in Malaysia: problems and challenges. Asian J Androl. 2011;13:526–33.PubMedCentralCrossRefPubMed

45.

Jimenez-Garcia R, Esteban-Hernandez J, Hernandez-Barrera V, Jimenez-Trujillo I, Lopez-de-Andres A, Carrasco GP. Clustering of unhealthy lifestyle behaviors is associated with nonadherence to clinical preventive recommendations among adults with diabetes. J Diabetes Complicat. 2011;25:107–13.CrossRefPubMed

46.

Liu JH, Tung TH, Tsai ST, Chou P, Chuang SY, Chen SJ, et al. A community-based epidemiologic study of gender differences in the relationship between insulin resistance/beta-cell dysfunction and diabetic retinopathy among type 2 diabetic patients in Kinmen. Taiwan Ophthalmol. 2006;220:252–8.CrossRef

47.

Livingstone C, Collison M. Sex steroids and insulin resistance. Clin Sci. 2002;102:151–66.CrossRefPubMed

48.

Ahmed KA, Muniandy S, Ismail IS, Ali RS. Evaluation of N ε - (carboxymethyl) lysine and lipid peroxidation in multiethnic Malaysian subjects with type 2 diabetes mellitus. Sci Res Essays. 2011;6:1957–62.

49.

Lorenzo C, Hanley AJ, Wagenknecht LE, Rewers MJ, Stefanovski D, Goodarzi MO, et al. Relationship of insulin sensitivity, insulin secretion, and adiposity with insulin clearance in a multiethnic population: the insulin resistance atherosclerosis study. Diabetes Care. 2012. [Epub ahead of print]

50.

Huang ES, Meigs JB, Singer DE. The effect of interventions to prevent cardiovascular disease in patients with type 2 diabetes mellitus. Am J Med. 2001;111:633–42.CrossRefPubMed

51.

Wu H, Xu MJ, Zou DJ, Han QJ, Hu X. Intensive glycemic control and macrovascular events in type 2 diabetes mellitus: a meta-analysis of randomized controlled trials. Chin Med J (Engl). 2010;123:2908–13.

52.

Hudon C, Fortin M, Dubois MF, Almirall J. Comorbidity and glycemia control among patients with type 2 diabetes in primary care. Diabetes Metab Syndr Obes. 2008;1:33–7.PubMedCentralPubMed

53.

Gitt AK, Bramlage P, Binz C, Krekler M, Plate T, Deeg E, et al. Hypoglycaemia is more frequent in type 2 diabetic patients with co-morbid vascular disease: an analysis of the DiaRegis registry. Eur J Prev Cardiol. 2012;19:765–72.CrossRefPubMed

54.

Sluik D, Buijsse B, Muckelbauer R, Kaaks R, Teucher B, Johnsen NF, et al. Physical activity and mortality in individuals with diabetes mellitus: a prospective study and meta-analysis. Arch Intern Med. 2012;1–11.

55.

van Dam H, van der Horst FG, Knoops L, Ryckman RM, Crebolder HFJM, van den Borne BHW. Social support in diabetes: a systematic review of controlled intervention studies. Patient Educ Couns. 2005;59:1–12.CrossRefPubMed

56.

Zeng Z, Li L, Zhang Z, Li Y, Wei Z, Huang K, et al. A meta-analysis of three polymorphisms in the endothelial nitric oxide synthase gene (NOS3) and their effect on the risk of diabetic nephropathy. Hum Genet. 2010;127:373–81.CrossRefPubMed

57.

Misra DP, Das S, Sahu PK. Prevalence of inflammatory markers (high-sensitivity C-reactive protein, nuclear factor-kappaB, and adiponectin) in Indian patients with type 2 diabetes mellitus with and without macrovascular complications. Metab Syndr Relat Disord. 2012;10:209–13.CrossRefPubMed

58.

Larrañaga I, Arteagoitia JM, Rodriguez JL, Gonzalez F, Esnaola S, Piniés JA, et al. Socio-economic inequalities in the prevalence of type 2 diabetes, cardiovascular risk factors and chronic diabetic complications in the Basque Country, Spain. Diabet Med. 2005;22:1047–53.CrossRefPubMed

Titel: Complication profiles and their associated factors in Malaysian adult type 2 diabetes mellitus—an analysis of ADCM registry
verfasst von: Boon-How Chew
Ping-Yein Lee
Ai-Theng Cheong
Mastura Ismail
Mohamad-Adam Bujang
Jamaiyah Haniff
Sri-Wahyu Taher
Pik-Pin Goh
Publikationsdatum: 01.09.2015
Verlag: Springer India
Erschienen in: International Journal of Diabetes in Developing Countries / Ausgabe 3/2015
Print ISSN: 0973-3930
Elektronische ISSN: 1998-3832
DOI: https://doi.org/10.1007/s13410-015-0298-z

Springer Medizin

Abstract

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