nach oben

Digestive Diseases and Sciences

Erschienen in:

01.06.2012 | Original Article

Comprehensive Self-Management Reduces the Negative Impact of Irritable Bowel Syndrome Symptoms on Sexual Functioning

verfasst von: Margaret D. Eugenio, Sang-Eun Jun, Kevin C. Cain, Monica E. Jarrett, Margaret M. Heitkemper

Erschienen in: Digestive Diseases and Sciences | Ausgabe 6/2012

Einloggen, um Zugang zu erhalten

Abstract

Background

Women with irritable bowel syndrome (IBS) report sexual dysfunction. Comprehensive self-management (CSM) intervention has been shown to reduce gastrointestinal, psychological, and somatic symptoms in IBS women. Whether this intervention also reduces sexual dysfunction is not known.

Aims

We sought to compare demographic and clinical factors in IBS women with and without sexual dysfunction as defined by the Arizona sexual experiences scale (ASEX) and to test the effects of CSM treatment on sexual dysfunction scores and on the sexual relations subscale of an IBS quality of life (IBSQOL) scale which measures the effect of IBS on sexual QOL.

Methods

IBS (Rome II) women enrolled in a randomized clinical trial of CSM treatment were characterized as having sexual dysfunction (N = 89) or not (N = 86) at baseline based on ASEX criteria. Baseline characteristics and symptoms were compared between the two groups. Post-intervention changes were compared between the CSM and the usual care arms of the randomized trial.

Results

Women meeting ASEX criteria for sexual dysfunction were older, had higher lifetime depression and antidepressant use, more primary care/MD visits, fewer mental healthcare visits, and greater sleep disturbance than those without sexual dysfunction. No significant group differences in gastrointestinal or somatic symptoms were observed. Compared with usual care treatment, CSM increased sexual QOL scores and had a weaker effect on ASEX scores.

Conclusions

Severity of IBS symptoms at baseline did not differ between IBS women with or without sexual dysfunction. The CSM intervention can reduce the effect of IBS on sexual QOL.

Brandt LJ, Bjorkman D, Fennerty MB, et al. Systematic review on the management of irritable bowel syndrome in north america. Am J Gastroenterol. 2002;97:S7–S26.PubMed

Fass R, Fullerton S, Naliboff B, Hirsh T, Mayer EA. Sexual dysfunction in patients with irritable bowel syndrome and non-ulcer dyspepsia. Digestion. 1998;59:79–85.PubMedCrossRef

Shifren JL, Monz BU, Russo PA, Segreti A, Johannes CB. Sexual problems and distress in united states women: Prevalence and correlates. Obstet Gynecol. 2008;112:970–978.PubMedCrossRef

West SL, D’Aloisio AA, Agans RP, Kalsbeek WD, Borisov NN, Thorp JM. Prevalence of low sexual desire and hypoactive sexual desire disorder in a nationally representative sample of us women. Arch Intern Med. 2008;168:1441–1449.PubMedCrossRef

Loeb TB, Williams JK, Carmona JV, et al. Child sexual abuse: Associations with the sexual functioning of adolescents and adults. Annu Rev Sex Res. 2002;13:307–345.PubMed

Dennerstein L, Dudley E, Burger H. Are changes in sexual functioning during midlife due to aging or menopause? Fertil Steril. 2001;76:456–460.PubMedCrossRef

Guthrie JR, Dennerstein L, Taffe JR, Lehert P, Burger HG. The menopausal transition: A 9-year prospective population-based study. The melbourne women’s midlife health project. Climacteric. 2004;7:375–389.PubMedCrossRef

Al-Azzawi F, Bitzer J, Brandenburg U, et al. Therapeutic options for postmenopausal female sexual dysfunction. Climacteric. 2010;13:103–120.PubMedCrossRef

Angst J. Sexual problems in healthy and depressed persons. Int Clin Psychopharmacol. 1998;13:S1–S4.PubMedCrossRef

10.

Rellini AH, Meston CM. Sexual self-schemas, sexual dysfunction, and the sexual responses of women with a history of childhood sexual abuse. Arch Sex Behav. 2011;40:351–362.PubMedCrossRef

11.

Heitkemper M, Jarrett M, Taylor P, Walker E, Landenburger K, Bond EF. Effect of sexual and physical abuse on symptom experiences in women with irritable bowel syndrome. Nurs Res. 2001;50:15–23.PubMedCrossRef

12.

Drossman DA, Camilleri M, Mayer EA, Whitehead WE. Aga technical review on irritable bowel syndrome. Gastroenterology. 2002;123:2108–2131.PubMedCrossRef

13.

Cain KC, Jarrett ME, Burr RL, Rosen S, Hertig VL, Heitkemper MM. Gender differences in gastrointestinal, psychological, and somatic symptoms in irritable bowel syndrome. Dig Dis Sci. 2009;54:1542–1549.PubMedCrossRef

14.

Shifren JL, Johannes CB, Monz BU, Russo PA, Bennett L, Rosen R. Help-seeking behavior of women with self-reported distressing sexual problems. J Womens Health (Larchmt). 2009;18:461–468.CrossRef

15.

Evangelia N, Kirana PS, Chiu G, Link C, Rosen R, Hatzichristou D. Level of bother and treatment-seeking predictors among male and female in-patients with sexual problems: A hospital-based study. J Sex Med. 2010;7:700–711.PubMedCrossRef

16.

McGahuey CA, Gelenberg AJ, Laukes CA, et al. The arizona sexual experience scale (asex): Reliability and validity. J Sex Marital Ther. 2000;26:25–40.PubMedCrossRef

17.

Williams VS, Edin HM, Hogue SL, Fehnel SE, Baldwin DS. Prevalence and impact of antidepressant-associated sexual dysfunction in three european countries: Replication in a cross-sectional patient survey. J Psychopharmacol. 2010;24:489–496.PubMedCrossRef

18.

Lew-Starowicz M, Gellert R. The sexuality and quality of life of hemodialyzed patients–ased multicenter study. J Sex Med. 2009;6:1062–1071.PubMedCrossRef

19.

Soykan A, Boztas H, Idilman R, et al. Sexual dysfunctions in hcv patients and its correlations with psychological and biological variables. Int J Impot Res. 2005;17:175–179.PubMedCrossRef

20.

Gelenberg AJ, McGahuey C, Laukes C, et al. Mirtazapine substitution in ssri-induced sexual dysfunction. J Clin Psychiatry. 2000;61:356–360.PubMedCrossRef

21.

Gralnek IM, Hays RD, Kilbourne A, Naliboff B, Mayer EA. The impact of irritable bowel syndrome on health-related quality of life. Gastroenterology. 2000;119:654–660.PubMedCrossRef

22.

Aboumarzouk OM, Agarwal T, Antakia R, Shariff U, Nelson RL: Cisapride for intestinal constipation. Cochrane Database Syst Rev. 2011:CD007780.

23.

Schey R, Rao SS. Lubiprostone for the treatment of adults with constipation and irritable bowel syndrome. Dig Dis Sci. 2011;56:1619–1625.PubMedCrossRef

24.

Pimentel M, Lembo A, Chey WD, et al. Rifaximin therapy for patients with irritable bowel syndrome without constipation. N Engl J Med. 2011;364:22–32.PubMedCrossRef

25.

Jarrett ME, Cain KC, Burr RL, Hertig VL, Rosen SN, Heitkemper MM. Comprehensive self-management for irritable bowel syndrome: Randomized trial of in-person vs. Combined in-person and telephone sessions. Am J Gastroenterol. 2009;104:3004–3014.PubMedCrossRef

26.

Drossman D, Corazziari E, Talley N, Thompson W, Whitehead WE. Rome ii: the functional gastrointestinal disorders. McLean: Degnon Associates, Inc.; 2000.

27.

Hahn BA, Kirchdoerfer LJ, Fullerton S, Mayer E. Evaluation of a new quality of life questionnaire for patients with irritable bowel syndrome. Aliment Pharmacol Ther. 1997;11:547–552.PubMedCrossRef

28.

Derogatis L. Brief symptom inventory: Administration, scoring and procedures manual. 4th ed. Minneapolis: National Computer Systems; 1993.

29.

Bernstein DP. Childhood trauma questionnaire. San Antonio: The Psychological Corporation; 1998.

30.

Bernstein DP, Ahluvalia T, Pogge D, Handelsman L. Validity of the childhood trauma questionnaire in an adolescent psychiatric population. J Am Acad Child Adolesc Psychiatry. 1997;36:340–348.PubMedCrossRef

31.

Buysse DJ, Reynolds CF 3rd. Monk TH, Berman SR, Kupfer DJ: The pittsburgh sleep quality index: A new instrument for psychiatric practice and research. Psychiatry Res. 1989;28:193–213.PubMedCrossRef

32.

Guthrie E, Creed FH, Whorwell PJ. Severe sexual dysfunction in women with the irritable bowel syndrome: Comparison with inflammatory bowel disease and duodenal ulceration. Br Med J (Clin Res Ed). 1987;295:577–578.CrossRef

33.

APA, ed. Diagnostic and statistical manual of mental disorders, text revision. 4th ed. Washington, DC: American Psychiatric Association; 2000.

34.

Choung RS, Herrick LM, Locke GR III, Zinsmeister AR, Talley NJ. Irritable bowel syndrome and chronic pelvic pain: A population-based study. J Clin Gastroenterol. 2010;44:696–701.PubMed

35.

Hahn BA, Kirchdoerfer LJ, Fullerton S, Mayer E. Patient-perceived severity of irritable bowel syndrome in relation to symptoms, health resource utilization and quality of life. Aliment Pharmacol Ther. 1997;11:553–559.PubMedCrossRef

36.

van den Brink M, Bandell-Hoekstra EN, Abu-Saad HH. The occurrence of recall bias in pediatric headache: A comparison of questionnaire and diary data. Headache. 2001;41:11–20.PubMedCrossRef

37.

Lewandowski AS, Palermo TM, Kirchner HL, Drotar D. Comparing diary and retrospective reports of pain and activity restriction in children and adolescents with chronic pain conditions. The Clinical Journal of Pain. 2009;25:299–306.PubMedCrossRef

38.

Niere K, Jerak A. Measurement of headache frequency, intensity and duration: Comparison of patient report by questionnaire and headache diary. Physiother Res Int. 2004;9:149–156.PubMedCrossRef

39.

Montejo AL, Llorca G, Izquierdo JA, Rico-Villademoros F. Incidence of sexual dysfunction associated with antidepressant agents: A prospective multicenter study of 1022 outpatients. Spanish working group for the study of psychotropic-related sexual dysfunction. J Clin Psychiatry. 2001;62:10–21.PubMed

40.

Kennedy SH, Rizvi S. Sexual dysfunction, depression, and the impact of antidepressants. J Clin Psychopharmacol. 2009;29:157–164.PubMedCrossRef

41.

Yang JC, Park K, Eun SJ, et al. Assessment of cerebrocortical areas associated with sexual arousal in depressive women using functional mr imaging. J Sex Med. 2008;5:602–609.PubMedCrossRef

42.

Ford AC, Talley NJ, Schoenfeld PS, Quigley EM, Moayyedi P. Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: Systematic review and meta-analysis. Gut. 2009;58:367–378.PubMedCrossRef

43.

Kennedy SH, Eisfeld BS, Dickens SE, Bacchiochi JR, Bagby RM. Antidepressant-induced sexual dysfunction during treatment with moclobemide, paroxetine, sertraline, and venlafaxine. J Clin Psychiatry. 2000;61:276–281.PubMedCrossRef

44.

Ashton AK, Mahmood A, Iqbal F. Improvements in ssri/snri-induced sexual dysfunction by switching to escitalopram. J Sex Marital Ther. 2005;31:257–262.PubMedCrossRef

45.

Ozmenler NK, Karlidere T, Bozkurt A, et al. Mirtazapine augmentation in depressed patients with sexual dysfunction due to selective serotonin reuptake inhibitors. Hum Psychopharmacol. 2008;23:321–326.PubMedCrossRef

46.

Safarinejad MR. Reversal of ssri-induced female sexual dysfunction by adjunctive bupropion in menstruating women: A double-blind, placebo-controlled and randomized study. J Psychopharmacol. 2011;25:370–378.PubMedCrossRef

47.

Bachmann G, Bobula J, Mirkin S. Effects of bazedoxifene/conjugated estrogens on quality of life in postmenopausal women with symptoms of vulvar/vaginal atrophy. Climacteric. 2010;13:132–140.PubMedCrossRef

48.

Schwartz TL, Nasra GS, Ashton AK, et al. An open-label study to evaluate switching from an ssri or snri to tiagabine to alleviate antidepressant-induced sexual dysfunction in generalized anxiety disorder. Ann Clin Psychiatry. 2007;19:25–30.PubMedCrossRef

Titel: Comprehensive Self-Management Reduces the Negative Impact of Irritable Bowel Syndrome Symptoms on Sexual Functioning
verfasst von: Margaret D. Eugenio
Sang-Eun Jun
Kevin C. Cain
Monica E. Jarrett
Margaret M. Heitkemper
Publikationsdatum: 01.06.2012
Verlag: Springer US
Erschienen in: Digestive Diseases and Sciences / Ausgabe 6/2012
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-012-2047-1

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Echinokokkose medikamentös behandeln oder operieren?

06.05.2024 DCK 2024 Kongressbericht

Die Therapie von Echinokokkosen sollte immer in spezialisierten Zentren erfolgen. Eine symptomlose Echinokokkose kann – egal ob von Hunde- oder Fuchsbandwurm ausgelöst – konservativ erfolgen. Wenn eine Op. nötig ist, kann es sinnvoll sein, vorher Zysten zu leeren und zu desinfizieren.

Umsetzung der POMGAT-Leitlinie läuft

03.05.2024 DCK 2024 Kongressbericht

Seit November 2023 gibt es evidenzbasierte Empfehlungen zum perioperativen Management bei gastrointestinalen Tumoren (POMGAT) auf S3-Niveau. Vieles wird schon entsprechend der Empfehlungen durchgeführt. Wo es im Alltag noch hapert, zeigt eine Umfrage in einem Klinikverbund.

Proximale Humerusfraktur: Auch 100-Jährige operieren?

01.05.2024 DCK 2024 Kongressbericht

Mit dem demographischen Wandel versorgt auch die Chirurgie immer mehr betagte Menschen. Von Entwicklungen wie Fast-Track können auch ältere Menschen profitieren und bei proximaler Humerusfraktur können selbst manche 100-Jährige noch sicher operiert werden.

Die „Zehn Gebote“ des Endokarditis-Managements

30.04.2024 Endokarditis Leitlinie kompakt

Worauf kommt es beim Management von Personen mit infektiöser Endokarditis an? Eine Kardiologin und ein Kardiologe fassen die zehn wichtigsten Punkte der neuen ESC-Leitlinie zusammen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Background

Aims

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2012

The Effects of 5-HT4 Receptor Agonist, Mosapride Citrate, on Visceral Hypersensitivity in a Rat Model

Safety of Capsule Endoscopy Using Human Body Communication in Patients with Cardiac Devices

Osteopontin Ablation Attenuates Progression of Colitis in TNBS Model

Tangible Resources for Preparing Patients for Antiviral Therapy for Chronic Hepatitis C

Infliximab Exerts No Direct Hepatotoxic Effect on HepG2 Cells In Vitro