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Digestive Diseases and Sciences

Digestive Diseases and Sciences OnlineFirst articles

20.01.2021 | Original Article

DRG1 Maintains Intestinal Epithelial Cell Junctions and Barrier Function by Regulating RAC1 Activity in Necrotizing Enterocolitis

Preterm infants are highly susceptible to developing unique diseases because of their immature organ systems. Necrotizing enterocolitis (NEC) is one of the leading causes of death in premature newborns between 28 and 34 weeks of gestational age [ 1 …,

20.01.2021 | Original Article

Disease-Based Risk Stratification of Postendoscopic Retrograde Cholangiopancreatography Pancreatitis for Common Bile Duct Stones

Common bile duct (CBD) stones are common worldwide. Because these can cause obstructive jaundice, acute cholangitis, and biliary pancreatitis, treatment with endoscopic retrograde cholangiopancreatography (ERCP) is consistently recommended in …

19.01.2021 | Original Article

The Sphincter of O’Beirne – Part 1: Study of 18 Normal Subjects

Consideration of the rectosigmoid junction as a contributor to the pathophysiology of constipation has had a checkered past, but in the last few decades, attention has been minimal. When contemplating its significance, the junction has been …

19.01.2021 | Original Article

The Sphincter of O’Beirne—Part 2: Report of a Case of Chronic Constipation with Autonomous Dyssynergia

Constipation is a common worldwide problem with a prevalence up to 35% in adults and up to 30% in children and contributes substantially to the financial burden of healthcare [ 1 ]. While in many cases, constipation can be treated successfully …

19.01.2021 | Original Article

P63 Deficiency and CDX2 Overexpression Lead to Barrett’s-Like Metaplasia in Mouse Esophageal Epithelium

As a premalignant lesion of esophageal adenocarcinoma (EAC), Barrett’s esophagus (BE) is characterized by the replacement of stratified squamous epithelium by a specialized or intestinalized columnar epithelium in the distal esophagus. BE is …

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